The burden of food allergy on children and teens: A systematic review.

bullying burden food allergy food hypersensitivity mixed methods psychosocial functioning quality of life

Journal

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
ISSN: 1399-3038
Titre abrégé: Pediatr Allergy Immunol
Pays: England
ID NLM: 9106718

Informations de publication

Date de publication:
03 2022
Historique:
revised: 24 01 2022
received: 29 07 2021
accepted: 03 02 2022
entrez: 26 3 2022
pubmed: 27 3 2022
medline: 8 4 2022
Statut: ppublish

Résumé

Over the last two decades, researchers have placed increasing attention on understanding how food allergy affects the health-related quality of life (HRQL) and psychosocial well-being of children and teens. In response, a number of reviews have been published that aim at synthesizing the literature. However, many of these papers focus narrowly on HRQL or suffer from methodological limitations. The current review aims to fill this gap by providing a comprehensive overview of the burden of pediatric food allergy by synthesizing the quantitative and qualitative literature. Findings from the present review provide evidence of reduced HRQL among children and teens with food allergy, particularly older children and those with more severe manifestations of the condition. In comparison to HRQL, the link between food allergy and psychosocial functioning is less clear; however, some evidence can be cited linking food allergy to greater levels of psychological distress. Qualitative evidence suggests that the burden of pediatric food allergy largely stems from worries surrounding exposures outside of the home and the social consequences of the condition. The current review also highlights several gaps in the literature, including a paucity of longitudinal research, research focused on predictors of psychological distress among children and teens with food allergy as well as a dearth of studies comparing rates of bullying in food-allergic and non-food-allergic samples. More emphasis should be placed on not only alleviating the social and psychological consequences of food allergy, but also on identifying and assisting those most acutely burdened by the condition.

Sections du résumé

BACKGROUND
Over the last two decades, researchers have placed increasing attention on understanding how food allergy affects the health-related quality of life (HRQL) and psychosocial well-being of children and teens. In response, a number of reviews have been published that aim at synthesizing the literature. However, many of these papers focus narrowly on HRQL or suffer from methodological limitations.
METHOD
The current review aims to fill this gap by providing a comprehensive overview of the burden of pediatric food allergy by synthesizing the quantitative and qualitative literature.
RESULTS
Findings from the present review provide evidence of reduced HRQL among children and teens with food allergy, particularly older children and those with more severe manifestations of the condition. In comparison to HRQL, the link between food allergy and psychosocial functioning is less clear; however, some evidence can be cited linking food allergy to greater levels of psychological distress. Qualitative evidence suggests that the burden of pediatric food allergy largely stems from worries surrounding exposures outside of the home and the social consequences of the condition. The current review also highlights several gaps in the literature, including a paucity of longitudinal research, research focused on predictors of psychological distress among children and teens with food allergy as well as a dearth of studies comparing rates of bullying in food-allergic and non-food-allergic samples.
CONCLUSION
More emphasis should be placed on not only alleviating the social and psychological consequences of food allergy, but also on identifying and assisting those most acutely burdened by the condition.

Identifiants

pubmed: 35338731
doi: 10.1111/pai.13743
doi:

Substances chimiques

Allergens 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

e13743

Informations de copyright

© 2022 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.

Références

Loh W, Tang MLK. The epidemiology of food allergy in the global context. Int J Environ Res Public Health. 2018;15(9):2043. doi:10.3390/ijerph15092043
Cummings AJ, Knibb RC, King RM, Lucas JS. The psychosocial impact of food allergy and food hypersensitivity in children, adolescents and their families: a review. Allergy. 2010;65(8):933-945. doi:10.1111/j.1398-9995.2010.02342.x
Morou Z, Tatsioni A, Dimoliatis IDK, Papadopoulos NG. Health-related quality of life in children with food allergy and their parents: a systematic review of the literature. J Investig Allergol Clin Immunol. 2014;24(6):382-395.
Marklund B, Ahlstedt S, Nordström G. Food hypersensitivity and quality of life. Curr Opin Allergy Clin Immunol. 2007;7(3):279-287.
Johnson SF, Woodgate RL. Qualitative research in teen experiences living with food-induced anaphylaxis: a meta-aggregation. J Adv Nurs. 2017;73(11):2534-2546.
Walkner M, Warren C, Gupta RS. Quality of life in food allergy patients and their families. Pediatr Clin North Am. 2015;62(6):1453-1461. doi:10.1016/j.pcl.2015.07.003
DunnGalvin A, Dubois AE, Flokstra-de Blok BM, Hourihane JO. The effects of food allergy on quality of life. Chem Immunol Allergy. 2015;101:235-252. doi:10.1159/000375106
Patel N, Herbert L, Green TD. The emotional, social, and financial burden of food allergies on children and their families. Allergy Asthma Proc. 2017;38(2):88-91. doi:10.2500/aap.2017.38.4028
Polloni L, Muraro A. Anxiety and food allergy: a review of the last two decades. Clin Exp Allergy. 2019;50:420-441. doi:10.1111/cea.13548
Antolín-Amérigo D, Manso L, Caminati M, et al. Quality of life in patients with food allergy. Clin Mol Allergy. 2016;14(1):1-10. doi:10.1186/s12948-016-0041-4
Golding MA, Gunnarsson NV, Middelveld R, Ahlstedt S, Protudjer JL. A scoping review of the caregiver burden of pediatric food allergy. Ann Allergy Asthma Immunol. 2021;127(5):536-547.e3. doi:10.1016/j.anai.2021.04.034
Dean J, Fenton NE, Shannon S, Elliott SJ, Clarke A. Disclosing food allergy status in schools: health-related stigma among school children in Ontario. Health Soc Care Community. 2016;24(5):e43-52. doi:10.1111/hsc.12244
Heyvaert M, Hannes K, Onghena P. Using Mixed Methods Research Synthesis for Literature Reviews: The Mixed Methods Research Synthesis Approach (Vol. 4). Sage Publications; 2016.
Karimi M, Brazier J. Health, health-related quality of life, and quality of life: what is the difference? Pharmacoeconomics. 2016;34(7):645-649. doi:10.1007/s40273-016-0389-9
National Heart L, and Blood Institute. Study Quality Assessment Tools. NIH. https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools
Borres N, Nilsson N, Drake I, et al. Parents’ perceptions are that their child's health-related quality of life is more impaired when they have a wheat rather than a grass allergy. Acta Paediatr. 2017;106(3):478-484. doi:10.1111/apa.13688
Avery NJ, King RM, Knight S, Hourihane JOB. Assessment of quality of life in children with peanut allergy. Pediatr Allergy Immunol. 2003;14(5):378-382. doi:10.1034/j.1399-3038.2003.00072.x
Cummings AJ, Knibb RC, Erlewyn-Lajeunesse M, King RM, Roberts G, Lucas JSA. Management of nut allergy influences quality of life and anxiety in children and their mothers. Pediatr Allergy Immunol. 2010;21(4 Pt 1):586-594. doi:10.1111/j.1399-3038.2009.00975.x
Flokstra-de Blok BMJ, Dubois AEJ, Vlieg-Boerstra BJ, et al. Health-related quality of life of food allergic patients: comparison with the general population and other diseases. Allergy. 2010;65(2):238-244. doi:10.1111/j.1398-9995.2009.02121.x
King RM, Knibb RC, Hourihane JO’B. Impact of peanut allergy on quality of life, stress and anxiety in the family. Allergy. 2009;64(3):461-468. doi:10.1111/j.1398-9995.2008.01843.x
Nowak-Wegrzyn A, Hass SL, Donelson SM, et al. The Peanut Allergy Burden Study: impact on the quality of life of patients and caregivers. World Allergy Organ J. 2021;14(2):100512. doi:10.1016/j.waojou.2021.100512
Roy KM, Roberts MC. Peanut allergy in children: relationships to health-related quality of life, anxiety, and parental stress. Clin Pediatr. 2011;50(11):1045-1051. doi:10.1177/0009922811412584
Ostblom E, Egmar AC, Gardulf A, Lilja G, Wickman M. The impact of food hypersensitivity reported in 9-year-old children by their parents on health-related quality of life. Allergy. 2008;63(2):211-218. doi:10.1111/j.1398-9995.2007.01559.x
Primeau MN, Kagan R, Joseph L, et al. The psychological burden of peanut allergy as perceived by adults with peanut allergy and the parents of peanut-allergic children. Clin Exp Allergy. 2000;30(8):1135-1143. doi:10.1046/j.1365-2222.2000.00889.x
Protudjer JLP, Jansson SA, Östblom E, et al. Health-related quality of life in children with objectively diagnosed staple food allergy assessed with a disease-specific questionnaire. Acta Paediatr. 2015;104(10):1047-1054. doi:10.1111/apa.13044
Sicherer SH, Noone SA, Muñoz-Furlong A. The impact of childhood food allergy on quality of life. Ann Allergy Asthma Immunol. 2001;87(6):461-464. doi:10.1016/S1081-1206(10)62258-2
Strinnholm Å, Hedman L, Winberg A, Jansson SA, Lindh V, Rönmark E. Health related quality of life among schoolchildren aged 12-13 years in relation to food hypersensitivity phenotypes: a population-based study. Clin Transl Allergy. 2017;7(1): doi:10.1186/s13601-017-0156-9
Szafron V, Anvari S, Pickett G, et al. Assessing health-related quality of life in children with food allergy and eosinophilic esophagitis. J Allergy Clin Immunol Pract. 2021;9(6):2520-2523.e2. doi:10.1016/j.jaip.2021.01.042
Valentine AZ, Knibb RC. Exploring quality of life in families of children living with and without a severe food allergy. Appetite. 2011;57(2):467-474. doi:10.1016/j.appet.2011.06.007
DunnGalvin A, Koman E, Raver E, et al. An examination of the food allergy quality of life questionnaire performance in a countrywide American sample of children: cross-cultural differences in age and impact in the United States and Europe. J Allergy Clin Immunol Pract. 2017;5(2):363-368.e2. doi:10.1016/j.jaip.2016.09.049
Pinczower GD, Bertalli NA, Bussmann N, et al. The effect of provision of an adrenaline autoinjector on quality of life in children with food allergy. J Allergy Clin Immunol. 2013;131(1):238-240.e1. doi:10.1016/j.jaci.2012.09.038
Indinnimeo L, Baldini L, De Vittori V, et al. Duration of a cow-milk exclusion diet worsens parents’ perception of quality of life in children with food allergies. BMC Pediatr. 2013;13:203. doi:10.1186/1471-2431-13-203
Soller L, Clarke AE, Lyttle A, et al. Comparing quality of life in Canadian children with peanut, sesame, and seafood allergy. J Allergy Clin Immunol Pract. 2020;8(1):352-354.
Thörnqvist V, Middelveld R, Wai HM, et al. Health-related quality of life worsens by school age amongst children with food allergy. Clin Transl Allergy 2019;9(1):1-5. doi:10.1186/s13601-019-0244-0
Wassenberg J, Cochard M-M, Dunngalvin A, et al. Parent perceived quality of life is age-dependent in children with food allergy. Pediatr Allergy Immunol. 2012;23(5):412-419. doi:10.1111/j.1399-3038.2012.01310.x
Miller J, Blackman AC, Wang HT, et al. Quality of life in food allergic children: results from 174 quality-of-life patient questionnaires. Ann Allergy Asthma Immunol. 2020;124(4):379-384.
Saleh-Langenberg J, Goossens NJ, Flokstra-de Blok BMJ, et al. Predictors of health-related quality of life of European food-allergic patients. Allergy. 2015;70(6):616-624. doi:10.1111/all.12582
Yilmaz EA, Cavkaytar O, Buyuktiryaki B, et al. Factors affecting food allergy-related quality of life from parents’ perception in Turkish children. Allergy Asthma Immunol Res. 2018;10(4):379-386.
Chow C, Pincus DB, Comer JS. Pediatric food allergies and psychosocial functioning: examining the potential moderating roles of maternal distress and overprotection. J Pediatr Psychol. 2015;40(10):1065-1074. doi:10.1093/jpepsy/jsv058
Acaster S, Gallop K, de Vries J, Ryan R, Vereda A, Knibb RC. Peanut allergy impact on productivity and quality of life (PAPRIQUA): caregiver-reported psychosocial impact of peanut allergy on children. Clin Exp Allergy. 2020;50(11):1249-1257.
Olabarri M, Vazquez P, Gonzalez-Posada A, et al. Risk factors for severe anaphylaxis in children. J Pediatr. 2020;225:193-197.
Protudjer JLP, Jansson SA, Middelveld R, et al. Impaired health-related quality of life in adolescents with allergy to staple foods. Clin Transl Allergy. 2016;6(1): 10.1186/s13601-016-0128-5
Boyano-Martínez T, García-Ara C, Pedrosa M, Díaz-Pena JM, Quirce S. Accidental allergic reactions in children allergic to cow's milk proteins. J Allergy Clin Immunol. 2009;123(4):883-888.
Hill DA, Grundmeier RW, Ram G, Spergel JM. The epidemiologic characteristics of healthcare provider-diagnosed eczema, asthma, allergic rhinitis, and food allergy in children: a retrospective cohort study. BMC Pediatr. 2016;16(1):1-8.
Afifi TO, Enns MW, Cox BJ, Martens PJ. Investigating health correlates of adolescent depression in Canada. Can J Public Health. 2005;96(6):427-431.
Ferro MA, Van Lieshout RJ, Scott JG, Alati R, Mamun AA, Dingle K. Condition-specific associations of symptoms of depression and anxiety in adolescents and young adults with asthma and food allergy. J Asthma. 2016;53(3):282-288. doi:10.3109/02770903.2015.1104694
Ferro MA, Van Lieshout RJ, Ohayon J, Scott JG. Emotional and behavioral problems in adolescents and young adults with food allergy. Allergy. 2016;71(4):532-540. doi:10.1111/all.12829
Goodwin RD, Rodgin S, Goldman R, et al. Food allergy and anxiety and depression among ethnic minority children and their caregivers. J Pediatr. 2017;187:258-264.e1. doi:10.1016/j.jpeds.2017.04.055
Lebovidge JS, Strauch H, Kalish LA, Schneider LC. Assessment of psychological distress among children and adolescents with food allergy. J Allergy Clin Immunol. 2009;124(6):1282-1288. doi:10.1016/j.jaci.2009.08.045
Polloni L, Ferruzza E, Ronconi L, et al. Mental health and behavior of food-allergic adolescents compared to a healthy matched sample. Ann Allergy Asthma Immunol. 2015;115(2):158-160. doi:10.1016/j.anai.2015.05.023
Shanahan L, Zucker N, Copeland WE, Costello EJ, Angold A. Are children and adolescents with food allergies at increased risk for psychopathology? J Psychosom Res. 2014;77(6):468-473. doi:10.1016/j.jpsychores.2014.10.005
Topal E, Catal F, Soylu N, et al. Psychiatric disorders and symptoms severity in pre-school children with cow's milk allergy. Allergol Immunopathol. 2016;44(5):445-449. doi:10.1016/j.aller.2016.03.001
Butler A, Van Lieshout RJ, Lipman EL, et al. Mental disorder in children with physical conditions: a pilot study. BMJ Open. 2018;8(1):e019011. doi:10.1136/bmjopen-2017-019011
Lau GY, Patel N, Umasunthar T, et al. Anxiety and stress in mothers of food-allergic children. Pediatr Allergy Immunol. 2014;25(3):236-242. doi:10.1111/pai.12203
Petrovic-Dovat L, Fausnight T, White AM, et al. Degree of anxiety in food allergic children in a tertiary care center. Ann Allergy Asthma Immunol. 2016;116(6):528-532. doi:10.1016/j.anai.2016.03.024
Weiss D, Marsac ML. Coping and posttraumatic stress symptoms in children with food allergies. Ann Allergy Asthma Immunol. 2016;117(5):561-562. doi:10.1016/j.anai.2016.08.022
van der Velde JL, Flokstra-de Blok BMJ, Dunngalvin A, Hourihane JO'B, Duiverman EJ, Dubois AEJ. Parents report better health-related quality of life for their food-allergic children than children themselves. Clin Exp Allergy. 2011;41(10):1431-1439. doi:10.1111/j.1365-2222.2011.03753.x
Muraro A, Polloni L, Lazzarotto F, et al. Comparison of bullying of food-allergic versus healthy schoolchildren in Italy. J Allergy Clin Immunol. 2014;134(3):749-751. doi:10.1016/j.jaci.2014.05.043
Annunziato RA, Rubes M, Ambrose MA, Mullarkey C, Shemesh E, Sicherer SH. Longitudinal evaluation of food allergy-related bullying. J Allergy Clin Immunol Pract. 2014;2(5):639-641. doi:10.1016/j.jaip.2014.05.001
Lieberman JA, Weiss C, Furlong TJ, Sicherer M, Sicherer SH. Bullying among pediatric patients with food allergy. Ann Allergy Asthma Immunol. 2010;105(4):282-286. doi:10.1016/j.anai.2010.07.011
Torabi B, Cardwell FS, Elliot SJ, Chan ES. The impact of bullying in Canadian children with confirmed food allergy and its influence on wearing medical identification. Paediatr Child Health. 2016;21(5):e39-e42.
Fong AT, Katelaris CH, Wainstein BK. Bullying in Australian children and adolescents with food allergies. Pediatr Allergy Immunol. 2018;29(7):740-746. doi:10.1111/pai.12955
Shemesh E, Annunziato RA, Ambrose MA, et al. Child and parental reports of bullying in a consecutive sample of children with food allergy. Pediatrics. 2013;131(1):e10-17. doi:10.1542/peds.2012-1180
Stjerna M-L. Food, risk and place: agency and negotiations of young people with food allergy. Sociol Health Illn. 2015;37(2):284-297. doi:10.1111/1467-9566.12215
Marklund B, Wilde-Larsson B, Ahlstedt S, Nordström G. Adolescents’ experiences of being food-hypersensitive: a qualitative study. BMC Nursing. 2007;6(8): doi:10.1186/1472-6955-6-8
Stensgaard A, Bindslev-Jensen C, Nielsen D. Peanut allergy as a family project: social relations and transitions in adolescence. J Clin Nurs. 2017;26(21-22):3371-3381. doi:10.1111/jocn.13696
Fenton NE, Elliott SJ, Cicutto L, Clarke AE, Harada L, McPhee E. Illustrating risk: anaphylaxis through the eyes of the food-allergic child. Risk Anal. 2011;31(1):171-183. doi:10.1111/j.1539-6924.2010.01488.x
DunnGalvin A, Gallop K, Acaster S, et al. APPEAL-2: a pan-European qualitative study to explore the burden of peanut-allergic children, teenagers and their caregivers. Clin and Exp Allergy. 2020;50(11):1238-1248. doi:10.1111/cea.13719
MacKenzie H, Roberts G, van Laar D, Dean T. Teenagers’ experiences of living with food hypersensitivity: a qualitative study. Pediatr Allergy Immunol. 2010;21(4 Pt 1):595-602. doi:10.1111/j.1399-3038.2009.00938.x
Akeson N, Worth A, Sheikh A. The psychosocial impact of anaphylaxis on young people and their parents. Clin Exp Allergy. 2007;37(8):1213-1220. doi:10.1111/j.1365-2222.2007.02758.x
Gallagher M, Worth A, Cunningham-Burley S, Sheikh A. Strategies for living with the risk of anaphylaxis in adolescence: qualitative study of young people and their parents. Prim Care Respir J. 2012;21(4):392-397. doi:10.4104/pcrj.2012.00072
Sasaki K, Sugiura S, Matsui T, et al. A workshop with practical training for anaphylaxis management improves the self-efficacy of school personnel. Allergol Int. 2015;64(2):156-160. doi:10.1016/j.alit.2014.10.005
Foster AA, Campbell RL, Lee S, Anderson JL. Anaphylaxis preparedness among preschool staff before and after an educational intervention. J Allergy. 2015;2015:1-5. doi:10.1155/2015/231862
Waserman S, Cruickshank H, Hildebrand KJ, et al. Prevention and management of allergic reactions to food in child care centers and schools: practice guidelines. J Allergy Clin Immunol. 2021;147(5):1561-1578. doi:10.1016/j.jaci.2021.01.034
Herbert L, DunnGalvin A. Psychotherapeutic treatment for psychosocial concerns related to food allergy: current treatment approaches and unmet needs. J Allergy Clin Immunol Pract. 2021;9(1):101-108. doi:10.1016/j.jaip.2020.10.037
Varni JW, Limbers CA, Burwinkle TM. Impaired health-related quality of life in children and adolescents with chronic conditions: a comparative analysis of 10 disease clusters and 33 disease categories/severities utilizing the PedsQL™ 4.0 Generic Core Scales. Health Qual Life Outcomes. 2007;5(1):1-5.
Upton P, Lawford J, Eiser C. Parent-child agreement across child health-related quality of life instruments: a review of the literature. Quality Life Res. 2008;17(6):895-913.
Silva N, Carona C, Crespo C, Canavarro MC. Quality of life in pediatric asthma patients and their parents: a meta-analysis on 20 years of research. Expert Rev. Pharmacoeconomics Outcomes Res. 2015;15(3):499-519. doi:10.1586/14737167.2015.1008459
Del Giudice MM, Marseglia A, Leonardi S, et al. Allergic rhinitis and quality of life in children. Int J Immunopathol. 2011;24(4):25-28.
Blome C, Radtke MA, Eissing L, Augustin M. Quality of life in patients with atopic dermatitis: disease burden, measurement, and treatment benefit. Am J Clin Dermatol. 2016;17(2):163-169.

Auteurs

Michael A Golding (MA)

Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

Ayel L R Batac (ALR)

Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

Nina V Gunnarsson (NV)

Department of Social Work, School of Health and Welfare, Jönköping University, Jönköping, Sweden.

Staffan Ahlstedt (S)

Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Roelinde Middelveld (R)

Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Jennifer L P Protudjer (JLP)

Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.
George and Fay Yee Centre for Healthcare Innovation, Winnipeg, Manitoba, Canada.
Department of Food and Human Nutritional Sciences, Faculty of Agricultural and Food Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

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