A discrete dielectrophoresis device for the separation of malaria-infected cells.
dielectrophoresis
duty cycle
malaria-infected cell
microfluidic device
red blood cell
Journal
Electrophoresis
ISSN: 1522-2683
Titre abrégé: Electrophoresis
Pays: Germany
ID NLM: 8204476
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
revised:
07
03
2022
received:
30
08
2021
accepted:
11
03
2022
pubmed:
27
3
2022
medline:
18
6
2022
entrez:
26
3
2022
Statut:
ppublish
Résumé
Malaria is a serious disease caused by Plasmodium parasites that infect red blood cells (RBCs). This paper presents the continuous separation of malaria-infected RBCs (iRBCs) from normal blood cells. The proposed method employed the discrete dielectrophoresis (DEP) in a microfluidic device with interdigitated electrodes. Our aim is to treat a sample having high concentration of cells to realize high throughput and to prevent the clogging of the microchannel with the use of the discrete DEP. The discrete DEP force for deflecting cells in the device was controlled by adjusting the magnitude, frequency, and duty cycle of the applied voltage. The effectiveness of the proposed method was demonstrated by separating the malaria-infected cells in samples having a cell concentration of 10
Identifiants
pubmed: 35338790
doi: 10.1002/elps.202100271
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1347-1356Informations de copyright
© 2022 Wiley-VCH GmbH.
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