No association of the common Asian mitochondrial DNA haplogroups with lung cancer in East Indian population.
SNP
association
haplogroups
lung cancer
mitochondrial DNA
Journal
Journal of basic and clinical physiology and pharmacology
ISSN: 2191-0286
Titre abrégé: J Basic Clin Physiol Pharmacol
Pays: Germany
ID NLM: 9101750
Informations de publication
Date de publication:
01 Sep 2023
01 Sep 2023
Historique:
received:
17
11
2021
accepted:
02
03
2022
medline:
27
3
2022
pubmed:
27
3
2022
entrez:
26
3
2022
Statut:
epublish
Résumé
Mitochondrial dysfunction has long been associated with the pathogenesis of lung cancer (LC). Mitochondrial DNA (mtDNA) haplogroups have been reported to modify the risk of LC in a few different populations; however, no study has been done among the Indians. Here, we explore the relationship between mtDNA haplogroups and LC in a representative eastern Indian sample set. Different combinations of six mtDNA SNPs, which define the major Asian mtDNA haplogroups M and N, and their sub-haplogroups D, G, M7, R, and F were genotyped via polymerase chain reaction (PCR) - restriction fragment length polymorphism (RFLP) - sequencing approach in 94 smoker LC patients and 100 healthy smoker controls from an eastern Indian cohort. The distribution of 7 mtDNA haplogroups did not show any significant differences between patients and controls (p<0.05). We did not find sub-haplogroup M7 in our study population. Our study is the first to indicate that the major Asian mtDNA haplogroups have no significant (p
Identifiants
pubmed: 35338796
pii: jbcpp-2021-0352
doi: 10.1515/jbcpp-2021-0352
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
663-668Informations de copyright
© 2022 Walter de Gruyter GmbH, Berlin/Boston.
Références
Siegel, RL, Miller, KD, Jemal, A. Cancer statistics, 2020. CA Canc J Clin 2020;70:7–30. https://doi.org/10.3322/caac.21590 .
doi: 10.3322/caac.21590
Raina, V, Malik, P. Lung cancer: prevalent trends & emerging concepts. Indian J Med Res 2015;141:5. https://doi.org/10.4103/0971-5916.154479 .
doi: 10.4103/0971-5916.154479
Church, DF, Pryor, WA. Free-radical chemistry of cigarette smoke and its toxicological implications. Environ Health Perspect 1985;64:111–26. https://doi.org/10.1289/ehp.8564111 .
doi: 10.1289/ehp.8564111
Pryor, WA, Stone, K. Oxidants in cigarette smoke. Radicals, hydrogen peroxide, peroxynitrate, and peroxynitrite. Ann N Y Acad Sci 1993;686:12–27. https://doi.org/10.1111/j.1749-6632.1993.tb39148.x .
doi: 10.1111/j.1749-6632.1993.tb39148.x
Croteau, DL, Bohr, VA. Repair of oxidative damage to nuclear and mitochondrial DNA in mammalian cells. J Biol Chem 1997;272:25409–12. https://doi.org/10.1074/jbc.272.41.25409 .
doi: 10.1074/jbc.272.41.25409
Hosgood, HD3rd, Liu, CS, Rothman, N, Weinstein, SJ, Bonner, MR, Shen, M, et al.. Mitochondrial DNA copy number and LC risk in a prospective cohort study. Carcinogenesis 2010;31:847–9. https://doi.org/10.1093/carcin/bgq045 .
doi: 10.1093/carcin/bgq045
Marcuello, A, Martinez-Redondo, D, Dahmani, Y, Casajús, JA, Ruiz-Pesini, E, Montoya, J, et al.. Human mitochondrial variants influence on oxygen consumption. Mitochondrion 2009;9:27–30. https://doi.org/10.1016/j.mito.2008.10.002 .
doi: 10.1016/j.mito.2008.10.002
Marcuello, A, Martinez-Redondo, D, Dahmani, Y, Terreros, JL, Aragonés, T, Casajús, JA, et al.. Steady exercise removes VO(2max) difference between mitochondrial genomic variants. Mitochondrion 2009;9:326–30. https://doi.org/10.1016/j.mito.2009.04.007 .
doi: 10.1016/j.mito.2009.04.007
Martinez-Redondo, D, Marcuello, A, Casajus, JA, Ara, I, Dahmani, Y, Montoya, J, et al.. Human mitochondrial haplogroup H: the highest VO2max consumer—is it a paradox? Mitochondrion 2010;10:102–7. https://doi.org/10.1016/j.mito.2009.11.005 .
doi: 10.1016/j.mito.2009.11.005
Wang, Z, Choi, S, Lee, J, Huang, YT, Chen, F, Zhao, Y, et al.. Mitochondrial variations in non-small cell LC (NSCLC) survival. Cancer Inf 2015;14(1 Suppl):1–9. https://doi.org/10.4137/CIN.S13976 .
doi: 10.4137/CIN.S13976
Zheng, S, Qian, P, Li, F, Qian, G, Wang, C, Wu, G, et al.. Association of mitochondrial DNA variations with LC risk in a Han Chinese population from southwestern China. PLoS One 2012;7:e31322. https://doi.org/10.1371/journal.pone.0031322 .
doi: 10.1371/journal.pone.0031322
Choi, SJ, Kim, SH, Kang, HY, Lee, J, Bhak, JH, Sohn, I, et al.. Mutational hotspots in the mitochondrial genome of LC. Biochem Biophys Res Commun 2011;407:23–7. https://doi.org/10.1016/j.bbrc.2011.02.078 .
doi: 10.1016/j.bbrc.2011.02.078
Qi, Y, Wei, Y, Wang, Q, Xu, H1, Wang, Y1, Yao, A, et al.. Heteroplasmy of mutant mitochondrial DNA A10398G and analysis of its prognostic value in non-small cell LC. Oncol Lett 2016;12:3081–8. https://doi.org/10.3892/ol.2016.5086 .
doi: 10.3892/ol.2016.5086
Singletary, SE, Allred, C, Ashley, P, Bassett, LW, Berry, D, Bland, K, et al.. Revision of the American Joint Committee on Cancer staging system for breast cancer. J Clin Oncol 2002;20:3628–36. https://doi.org/10.1200/jco.2002.02.026 .
doi: 10.1200/jco.2002.02.026
Chen, YF, Chen, WJ, Lin, XZ, Zhang, QJ, Cai, JP, Liou, CW, et al.. Mitochondrial DNA haplogroups and the risk of sporadic Parkinson’s disease in Han Chinese. Chin Med J (Engl) 2015;128:1748–54. https://doi.org/10.4103/0366-6999.159348 .
doi: 10.4103/0366-6999.159348
Herrnstadt, C, Elson, JL, Fahy, E, Preston, G, Turnbull, DM, Anderson, C, et al.. Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups. Am J Hum Genet 2002;70:1152–71. https://doi.org/10.1086/339933 .
doi: 10.1086/339933
Sambrook, J, Russell, DW. Molecular cloning: a laboratory manual , 3rd ed. New York: CHSL Press; 2001, 1:6.4-12 p.
Metspalu, M, Kivisild, T, Metspalu, E, Parik, J, Hudjashov, G, Kaldma, K, et al.. Most of the extant mtDNA boundaries in south and southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans. BMC Genet 2004;5:26. https://doi.org/10.1186/1471-2156-5-26 .
doi: 10.1186/1471-2156-5-26
Luchini, C, Nottegar, A, Vaona, A, Stubbs, B, Demurtas, J, Maggi, S, et al.. Female-specific association among I, J and K mitochondrial genetic haplogroups and cancer: a longitudinal cohort study. Cancer Genet 2018;224–225:29–36. https://doi.org/10.1016/j.cancergen.2018.04.003 .
doi: 10.1016/j.cancergen.2018.04.003
Otsuka, T, Ueda, K, Furukawa, T, Koriyama, C, Inoue, I, Sato, M. Significance of mitochondrial DNA haplogroup on epidermal growth factor receptor mutation in Japanese patients with lung adenocarcinoma. Anticancer Res 2021;41:3997–4004. https://doi.org/10.21873/anticanres.15197 .
doi: 10.21873/anticanres.15197
Darvishi, K, Sharma, S, Bhat, AK, Rai, E, Bamezai, RN. Mitochondrial DNA G10398A polymorphism imparts maternal Haplogroup N a risk for breast and esophageal cancer. Cancer Lett 2007;249:249–55. https://doi.org/10.1016/j.canlet.2006.09.005 .
doi: 10.1016/j.canlet.2006.09.005
Fang, Y, Yang, HY, Shi, YH, Cui, JH, Li, LY, Xu, YC, et al.. Mitochondrial DNA haplogroups and somatic mutations are associated with lung cancer in patients from Southwest China. Genet Mol Res 2015;14:5031–43. https://doi.org/10.4238/2015.may.12.6 .
doi: 10.4238/2015.may.12.6
Barnabas, S, Shouche, Y, Suresh, CG. High-resolution mtDNA studies of the Indian population: implications for palaeolithic settlement of the Indian subcontinent. Ann Hum Genet 2006;70:42–58. https://doi.org/10.1111/j.1529-8817.2005.00207.x .
doi: 10.1111/j.1529-8817.2005.00207.x
Yang, Y, Shou, Z, Zhang, P, He, Q, Xiao, H, Xu, Y, et al.. Mitochondrial DNA haplogroup R predicts survival advantage in severe sepsis in the Han population. Genet Med 2008;10:187–92. https://doi.org/10.1097/gim.0b013e318163c343 .
doi: 10.1097/gim.0b013e318163c343
Macaulay, V, Richards, M, Hickey, E, Vega, E, Cruciani, F, Guida, V, et al.. The emerging tree of West Eurasian mtDNAs: a synthesis of control-region sequences and RFLPs. Am J Hum Genet 1999;64:232–49. https://doi.org/10.1086/302204 .
doi: 10.1086/302204
Ji, F, Sharpley, MS, Derbeneva, O, Alves, LS, Qian, P, Wang, Y, et al.. Mitochondrial DNA variant associated with Leber hereditary optic neuropathy and high-altitude Tibetans. Proc Natl Acad Sci USA 2012;109:7391–6. https://doi.org/10.1073/pnas.1202484109 .
doi: 10.1073/pnas.1202484109
Kazdal, D, Harms, A, Endris, V, Penzel, R, Kriegsmann, M, Eichhorn, F, et al.. Prevalence of somatic mitochondrial mutations and spatial distribution of mitochondria in non-small cell lung cancer. Br J Cancer 2017;117:220–6. https://doi.org/10.1038/bjc.2017.155 .
doi: 10.1038/bjc.2017.155