The pathogenesis and treatment mechanism of Parkinson's disease from the perspective of traditional Chinese medicine.
Chinese medicine
Parkinson's disease
pathogenesis
treatment mechanism
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
ISSN: 1618-095X
Titre abrégé: Phytomedicine
Pays: Germany
ID NLM: 9438794
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
18
10
2021
revised:
26
02
2022
accepted:
11
03
2022
pubmed:
27
3
2022
medline:
27
4
2022
entrez:
26
3
2022
Statut:
ppublish
Résumé
Parkinson's disease (PD) is the second most common neurodegenerative disease with no treatment currently available to modify its progression. Traditional Chinese medicine (TCM) has gained attention for its unique theoretical basis and clinical effects. Many studies have reported on the clinical effects and pharmacological mechanisms of Chinese herbs in PD. However, few studies have focused on the treatment mechanisms of anti-PD TCM drugs from the perspective of TCM itself. To elaborate the treatment mechanisms of anti-PD TCM drugs in the perspective of TCM. We performed a literature survey using traditional books of Chinese medicine and online scientific databases including PubMed, Web of Science, Google Scholar, China National Knowledge Infrastructure (CNKI), and others up to July 2021. TCM theory states that PD is caused by a dysfunction of the zang-fu organs (liver, spleen, kidney, and lung) and subsequent pathogenic factors (wind, fire, phlegm, and blood stasis). Based on the pathogenesis, removing pathogenic factors and restoring visceral function are two primary treatment principles for PD in TCM. The former includes dispelling wind, clearing heat, resolving phlegm, and promoting blood circulation, while the latter involves nourishing the liver and kidney and strengthening the spleen. The anti-PD mechanisms of the active ingredients of TCM compounds and herbs at different levels include anti-apoptosis, anti-inflammation, and anti-oxidative stress, as well as the restoration of mitochondrial function and the regulation of autophagy and neurotransmitters. Chinese herbs and prescriptions can be used to treat PD by targeting multiple pharmacological mechanisms.
Sections du résumé
BACKGROUND
BACKGROUND
Parkinson's disease (PD) is the second most common neurodegenerative disease with no treatment currently available to modify its progression. Traditional Chinese medicine (TCM) has gained attention for its unique theoretical basis and clinical effects. Many studies have reported on the clinical effects and pharmacological mechanisms of Chinese herbs in PD. However, few studies have focused on the treatment mechanisms of anti-PD TCM drugs from the perspective of TCM itself.
PURPOSE
OBJECTIVE
To elaborate the treatment mechanisms of anti-PD TCM drugs in the perspective of TCM.
METHODS
METHODS
We performed a literature survey using traditional books of Chinese medicine and online scientific databases including PubMed, Web of Science, Google Scholar, China National Knowledge Infrastructure (CNKI), and others up to July 2021.
RESULTS
RESULTS
TCM theory states that PD is caused by a dysfunction of the zang-fu organs (liver, spleen, kidney, and lung) and subsequent pathogenic factors (wind, fire, phlegm, and blood stasis). Based on the pathogenesis, removing pathogenic factors and restoring visceral function are two primary treatment principles for PD in TCM. The former includes dispelling wind, clearing heat, resolving phlegm, and promoting blood circulation, while the latter involves nourishing the liver and kidney and strengthening the spleen. The anti-PD mechanisms of the active ingredients of TCM compounds and herbs at different levels include anti-apoptosis, anti-inflammation, and anti-oxidative stress, as well as the restoration of mitochondrial function and the regulation of autophagy and neurotransmitters.
CONCLUSION
CONCLUSIONS
Chinese herbs and prescriptions can be used to treat PD by targeting multiple pharmacological mechanisms.
Identifiants
pubmed: 35338993
pii: S0944-7113(22)00122-2
doi: 10.1016/j.phymed.2022.154044
pii:
doi:
Substances chimiques
Drugs, Chinese Herbal
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
154044Informations de copyright
Copyright © 2022. Published by Elsevier GmbH.