Neuropathways of theory of mind in schizophrenia: A systematic review and meta-analysis.
Neuroimaging Techniques
Neuropathways
Schizophrenia
Social cognition
Theory of mind
Journal
Neuroscience and biobehavioral reviews
ISSN: 1873-7528
Titre abrégé: Neurosci Biobehav Rev
Pays: United States
ID NLM: 7806090
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
21
09
2021
revised:
11
03
2022
accepted:
14
03
2022
pubmed:
28
3
2022
medline:
24
5
2022
entrez:
27
3
2022
Statut:
ppublish
Résumé
Social cognition is significantly associated with daily functioning in patients with schizophrenia. Its neural basis remains unknown. A systematic literature search was performed. Studies using imaging to measure theory of mind (ToM) in schizophrenia were identified. Imaging data were synthesized using the seed-based d mapping approach. Potential neuropathways were hypothesized based on the identified brain regions activated during ToM tasks. A total of 25 studies were included in the present study. Compared with healthy people, patients with schizophrenia showed hyperactivations in superior longitudinal fasciculus II and hypoactivations in superior frontal gyrus, precuneus and cuneus, and precentral gyrus during ToM tasks. The primary brain regions involved in the potential neuropathways in schizophrenia were the middle temporal gyrus, superior and inferior frontal gyrus, and supplementary motor areas. Deactivated brain regions in schizophrenia overlapped with the default mode and salience networks. Our findings shed light on how to develop a diagnostic tool for deficits in social cognition using neuroimaging techniques and effective therapeutic interventions to rectify dysfunction in schizophrenia.
Sections du résumé
BACKGROUND
Social cognition is significantly associated with daily functioning in patients with schizophrenia. Its neural basis remains unknown.
METHODS
A systematic literature search was performed. Studies using imaging to measure theory of mind (ToM) in schizophrenia were identified. Imaging data were synthesized using the seed-based d mapping approach. Potential neuropathways were hypothesized based on the identified brain regions activated during ToM tasks.
RESULTS
A total of 25 studies were included in the present study. Compared with healthy people, patients with schizophrenia showed hyperactivations in superior longitudinal fasciculus II and hypoactivations in superior frontal gyrus, precuneus and cuneus, and precentral gyrus during ToM tasks. The primary brain regions involved in the potential neuropathways in schizophrenia were the middle temporal gyrus, superior and inferior frontal gyrus, and supplementary motor areas.
CONCLUSION
Deactivated brain regions in schizophrenia overlapped with the default mode and salience networks. Our findings shed light on how to develop a diagnostic tool for deficits in social cognition using neuroimaging techniques and effective therapeutic interventions to rectify dysfunction in schizophrenia.
Identifiants
pubmed: 35339482
pii: S0149-7634(22)00114-2
doi: 10.1016/j.neubiorev.2022.104625
pii:
doi:
Types de publication
Journal Article
Meta-Analysis
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
104625Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.