Perivascular adipose tissue-mediated arterial stiffening in aging and disease: An emerging translational therapeutic target?
Cholesterol
Exercise
Heart failure
Nutraceutical
Obesity
Pharmacology
Journal
Pharmacological research
ISSN: 1096-1186
Titre abrégé: Pharmacol Res
Pays: Netherlands
ID NLM: 8907422
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
27
12
2021
revised:
14
02
2022
accepted:
26
02
2022
pubmed:
28
3
2022
medline:
14
4
2022
entrez:
27
3
2022
Statut:
ppublish
Résumé
Cardiovascular diseases (CVD) are the leading cause of mortality in modernized societies. Arterial stiffening with aging and disease is a key pathological event leading to increased CVD morbidity and mortality. Perivascular adipose tissue (PVAT) is a fat depot not widely studied yet has direct and profound effects on arterial stiffening. Identifying PVAT as a novel therapeutic target to lower arterial stiffness and thereby CVD risk has potentially important clinical ramifications. Thus, herein, we will overview the current preclinical evidence and the associated mechanisms for PVAT to promote arterial stiffness with aging and other disease conditions. We will also discuss viable translational lifestyle and pharmacological interventions for altering PVAT function that may de-stiffen arteries. Last, the translational potential for PVAT as a therapeutic target to lower arterial stiffness and CVD risk for clinical populations will be discussed.
Identifiants
pubmed: 35339679
pii: S1043-6618(22)00095-0
doi: 10.1016/j.phrs.2022.106150
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
106150Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.