Molecular landscape of c-Myc signaling in prostate cancer: A roadmap to clinical translation.

Cell Line, Tumor Cell Proliferation / genetics Gene Expression Regulation, Neoplastic Humans Male Phosphatidylinositol 3-Kinases / metabolism Prostatic Neoplasms / genetics Proto-Oncogene Proteins c-myc / genetics Signal Transduction
Biomarker C-Myc Drug resistance Non-coding RNAs Prostate cancer

Journal

Pathology, research and practice
ISSN: 1618-0631
Titre abrégé: Pathol Res Pract
Pays: Germany
ID NLM: 7806109

Informations de publication

Date de publication:
May 2022
Historique:
received: 29 01 2022
revised: 02 03 2022
accepted: 17 03 2022
pubmed: 28 3 2022
medline: 6 5 2022
entrez: 27 3 2022
Statut: ppublish

Résumé

The c-Myc signaling is a new emerging target in cancer therapy. Activation of c-Myc signaling leads to cancer growth and invasion in vitro and in vivo. The stability of c-Myc can also mediate drug resistance and radioresistance in cancers. The apoptosis inhibition and enhancing cell cycle progression are mediated by c-Myc overexpression. On the other hand, prostate cancer (PC) is the most common cancer in men and causes high death. The present review focuses on c-Myc signaling in PC. The c-Myc overexpression is in favor of PC growth and migration. Upon c-Myc inhibition, apoptosis and cell cycle arrest (G0/G1 phase) occur in PC cells. The c-Myc induces glycolysis in enhancing PC growth. Besides, stability and overexpression of c-Myc can mediate resistance of PC cells to chemotherapy and radiotherapy. The inhibition of c-Myc by both anti-tumor agents and genetic tools suppress PC progression. The miRNAs, lncRNAs, circRNAs and other factors such as PI3K/Akt can act as upstream regulator of c-Myc signaling. The c-Myc can function as independent prognostic and diagnostic factor in PC patients. The c-Myc upregulation is associated with reduced overall survival, clinical stage, lymph node metastasis and undesirable prognosis of PC patients.

Identifiants

DOI: 10.1016/j.prp.2022.153851 PMID: 35339914
pubmed: 35339914
pii: S0344-0338(22)00094-2
doi: 10.1016/j.prp.2022.153851
pii:
doi:

Substances chimiques

MYC protein, human 0
Proto-Oncogene Proteins c-myc 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

153851

Informations de copyright

Copyright © 2022 Elsevier GmbH. All rights reserved.

Auteurs

Mojdeh Amini Faskhoudi (MA)

Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Farhikhtegan Medical Convergence sciences Research Center, Farhikhtegan Hospital Tehran Medical sciences, Islamic Azad University, Tehran, Iran.

Pejman Molaei (P)

Department of Molecular Medicine and Genetics, Research Center for Molecular Medicine, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Mehrdokht Sadrkhanloo (M)

Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

Sima Orouei (S)

Department of Biology, Faculty of Science, Islamic Azad University, Science and Research Branch, Tehran, Iran.

Mehrdad Hashemi (M)

Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Farhikhtegan Medical Convergence sciences Research Center, Farhikhtegan Hospital Tehran Medical sciences, Islamic Azad University, Tehran, Iran.

Saied Bokaie (S)

Department of Food Hygiene and Quality Control, Division of epidemiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

Mohsen Rashidi (M)

Department Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran; The Health of Plant and Livestock Products Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

Maliheh Entezari (M)

Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Farhikhtegan Medical Convergence sciences Research Center, Farhikhtegan Hospital Tehran Medical sciences, Islamic Azad University, Tehran, Iran.

Ali Zarrabi (A)

Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Istanbul 34396, Turkey.

Kiavash Hushmandi (K)

Department of Food Hygiene and Quality Control, Division of epidemiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. Electronic address: Kiavash.hushmandi@gmail.com.

Sepideh Mirzaei (S)

Department of Biology, Faculty of Science, Islamic Azad University, Science and Research Branch, Tehran, Iran. Electronic address: sepidehmirzaei.smv@gmail.com.

Mohammad Hossein Gholami (MH)

DVM. Graduated, Faculty of Veterinary Medicine, Kazerun Branch, Islamic Azad University, Kazerun, Iran. Electronic address: hoseingholami2020@yahoo.com.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Molecular landscape of c-Myc signaling in...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Molecular landscape of c-Myc signaling in...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Molecular landscape of c-Myc signaling in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Molecular landscape of c-Myc signaling in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphatidylinositol 3-kinases › Molecular landscape of c-Myc signaling in...
questionsmedicales.fr › Maladies urogénitales › Tumeurs de l'appareil urogénital › Tumeurs de l'appareil génital mâle › Tumeurs de la prostate › Molecular landscape of c-Myc signaling in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique hélice-boucle-hélice › Protéines proto-oncogènes c-myc › Molecular landscape of c-Myc signaling in...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Molecular landscape of c-Myc signaling in...