PQQ Dietary Supplementation Prevents Alkylating Agent-Induced Ovarian Dysfunction in Mice.
alkylating agents
ovarian aging
ovarian dysfunction
protection
pyrroloquinoline quinine
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2022
2022
Historique:
received:
22
09
2021
accepted:
03
02
2022
entrez:
28
3
2022
pubmed:
29
3
2022
medline:
23
4
2022
Statut:
epublish
Résumé
Alkylating agents (AAs) that are commonly used for cancer therapy cause great damage to the ovary. Pyrroloquinoline-quinine (PQQ), which was initially identified as a redox cofactor for bacterial dehydrogenases, has been demonstrated to benefit the fertility of females. The aim of this study was to investigate whether PQQ dietary supplementation plays a protective role against alkylating agent-induced ovarian dysfunction. A single dose of busulphan (20 mg/kg) and cyclophosphamide (CTX, 120 mg/kg) were used to establish a mouse model of ovarian dysfunction. Feed containing PQQNa
Identifiants
pubmed: 35340329
doi: 10.3389/fendo.2022.781404
pmc: PMC8948422
doi:
Substances chimiques
Alkylating Agents
0
Pyrroles
0
Quinolines
0
pyrroloquinoline
0
Quinine
A7V27PHC7A
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
781404Informations de copyright
Copyright © 2022 Dai, Yi, Wang, Xia, Tao, Wu, Miao and Chen.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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