Computational Toxicology
Expert Alerts
Hazard Identification
Hepatotoxicity
In Silico
In Silico Toxicology Protocols
Liver toxicity
Organ toxicity
QSAR
Read-across
Risk Assessment
Journal
Computational toxicology (Amsterdam, Netherlands)
ISSN: 2468-1113
Titre abrégé: Comput Toxicol
Pays: Netherlands
ID NLM: 101708081
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
entrez:
28
3
2022
pubmed:
29
3
2022
medline:
29
3
2022
Statut:
ppublish
Résumé
Hepatotoxicity is one of the most frequently observed adverse effects resulting from exposure to a xenobiotic. For example, in pharmaceutical research and development it is one of the major reasons for drug withdrawals, clinical failures, and discontinuation of drug candidates. The development of faster and cheaper methods to assess hepatotoxicity that are both more sustainable and more informative is critically needed. The biological mechanisms and processes underpinning hepatotoxicity are summarized and experimental approaches to support the prediction of hepatotoxicity are described, including toxicokinetic considerations. The paper describes the increasingly important role of
Identifiants
pubmed: 35340402
doi: 10.1016/j.comtox.2021.100187
pmc: PMC8955833
mid: NIHMS1743525
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIEHS NIH HHS
ID : R44 ES026909
Pays : United States
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