Peripartum cardiomyopathy: a global effort to find the cause and cure for the rare and little understood disease.
Gene mutation in cardiomyocytes
Heart failure in pregnancy
Peripartum cardiomyopathy
Journal
Biophysical reviews
ISSN: 1867-2450
Titre abrégé: Biophys Rev
Pays: Germany
ID NLM: 101498573
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
13
12
2021
accepted:
06
01
2022
entrez:
28
3
2022
pubmed:
29
3
2022
medline:
29
3
2022
Statut:
epublish
Résumé
In this review, we present our current understanding of peripartum cardiomyopathy (PPCM) based on reports of the incidence, diagnosis and current treatment options. We summarise opinions on whether PPCM is triggered by vascular and/or hormonal causes and examine the influence of comorbidities such as preeclampsia. Two articles published in 2021 strongly support the hypothesis that PPCM may be a familial disease. Using large cohorts of PPCM patients, they summarised the available genomic DNA sequence data that are expressed in human cardiomyocytes. While PPCM is considered a disease predominately affecting the left ventricle, there are data to suggest that some cases also involve right ventricular failure. Finally, we conclude that there is sufficient evidence to warrant an RNAseq investigation and that this would be most informative if performed at the cardiomyocytes level rather than analysing genomic DNA from the peripheral circulation. Given the rarity of PPCM, the combined resources of international human heart tissue biobanks have assembled 30 ventricular tissue samples from PPCM patients, and we are actively seeking to enlarge this patient base by collaborating with human heart tissue banks and research laboratories who would like to join this endeavour.
Identifiants
pubmed: 35340597
doi: 10.1007/s12551-022-00930-0
pii: 930
pmc: PMC8921403
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
369-379Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL148785
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL149164
Pays : United States
Informations de copyright
© The Author(s) 2022.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing interests.
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