Vitamin B12 (Cobalamin) Deficiency in Overt and Subclinical Primary Hypothyroidism.
Vitamin B12 deficiency
celiac disease
hypothyroidism
pernicious anemia
subclinical hypothyroidism
Journal
Clinical medicine insights. Endocrinology and diabetes
ISSN: 1179-5514
Titre abrégé: Clin Med Insights Endocrinol Diabetes
Pays: United States
ID NLM: 101578235
Informations de publication
Date de publication:
2022
2022
Historique:
received:
30
11
2021
accepted:
22
02
2022
entrez:
28
3
2022
pubmed:
29
3
2022
medline:
29
3
2022
Statut:
epublish
Résumé
B12 (cobalamin) deficiency has been reported in hypothyroid patients with variable prevalence rates thus routine screening of hypothyroid patients was recommended by some and discouraged by others. We aimed to assess the prevalence of B12 deficiency among hypothyroid patients and to evaluate for pernicious anemia and celiac disease as etiologies. A total 133 patients were included. Thyroid hormones and thyroid peroxidase (TPO) autoantibodies were measured. Serum B12 was measured and if deficient, intrinsic factor antibodies (IFAB) and tissue transglutaminase (tTG) antibodies were evaluated. Our study included 45 patients with overt hypothyroidism (OH), 48 patients with subclinical hypothyroidism (SCH), and 40 patients as controls. Mean age was 34.3 years and 82% were females. TPO antibodies were positive in 73.5% of OH and 51.1% of SCH patients. B12 deficiency was detected in 33.3%, 47.9%, and 37.5% of OH, SCH, and controls, respectively with no significant difference ( We did not find a higher prevalence of B12 deficiency among hypothyroid patients nor an association with TPO positivity. Borderline B12 levels were more prevalent among hypothyroid patients.
Sections du résumé
Background
UNASSIGNED
B12 (cobalamin) deficiency has been reported in hypothyroid patients with variable prevalence rates thus routine screening of hypothyroid patients was recommended by some and discouraged by others. We aimed to assess the prevalence of B12 deficiency among hypothyroid patients and to evaluate for pernicious anemia and celiac disease as etiologies.
Methods
UNASSIGNED
A total 133 patients were included. Thyroid hormones and thyroid peroxidase (TPO) autoantibodies were measured. Serum B12 was measured and if deficient, intrinsic factor antibodies (IFAB) and tissue transglutaminase (tTG) antibodies were evaluated.
Results
UNASSIGNED
Our study included 45 patients with overt hypothyroidism (OH), 48 patients with subclinical hypothyroidism (SCH), and 40 patients as controls. Mean age was 34.3 years and 82% were females. TPO antibodies were positive in 73.5% of OH and 51.1% of SCH patients. B12 deficiency was detected in 33.3%, 47.9%, and 37.5% of OH, SCH, and controls, respectively with no significant difference (
Conclusion
UNASSIGNED
We did not find a higher prevalence of B12 deficiency among hypothyroid patients nor an association with TPO positivity. Borderline B12 levels were more prevalent among hypothyroid patients.
Identifiants
pubmed: 35340751
doi: 10.1177/11795514221086634
pii: 10.1177_11795514221086634
pmc: PMC8943463
doi:
Types de publication
Journal Article
Langues
eng
Pagination
11795514221086634Informations de copyright
© The Author(s) 2022.
Déclaration de conflit d'intérêts
Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Références
Indian J Clin Biochem. 2015 Apr;30(2):217-20
pubmed: 25883432
Int J Environ Res Public Health. 2015 Jul 31;12(8):9036-45
pubmed: 26264015
J Pak Med Assoc. 2008 May;58(5):258-61
pubmed: 18655403
Med Clin North Am. 2012 Mar;96(2):203-21
pubmed: 22443971
Biochimie. 2013 May;95(5):1047-55
pubmed: 23416723
Thyroid. 2007 Dec;17(12):1211-23
pubmed: 18177256
Pol Arch Intern Med. 2017 May 31;127(5):352-360
pubmed: 28400547
N Engl J Med. 2017 Jun 29;376(26):2556-2565
pubmed: 28657873
Eur Thyroid J. 2013 Dec;2(4):215-28
pubmed: 24783053
Am J Gastroenterol. 2001 Mar;96(3):745-50
pubmed: 11280545
Thyroid. 2010 Dec;20(12):1385-9
pubmed: 21054212
J Neurol Neurosurg Psychiatry. 2000 Jun;68(6):750-5
pubmed: 10811699
Br J Haematol. 2014 Aug;166(4):496-513
pubmed: 24942828
Clin Lab. 2021 May 1;67(5):
pubmed: 33978377
J Clin Endocrinol Metab. 1990 Sep;71(3):661-9
pubmed: 2168432
J Clin Endocrinol Metab. 2014 Sep;99(9):3353-62
pubmed: 24915118
Am J Clin Nutr. 2005 Aug;82(2):442-50
pubmed: 16087991
Am J Med Sci. 2008 Jul;336(1):50-2
pubmed: 18626236
Clin Chem Lab Med. 2015 Jul;53(8):1205-13
pubmed: 25720078
Endocr J. 2012;59(3):213-20
pubmed: 22200582
JAMA. 2014 Apr 16;311(15):1563-5
pubmed: 24737370
Blood. 2017 May 11;129(19):2603-2611
pubmed: 28360040
Lancet. 2017 Sep 23;390(10101):1550-1562
pubmed: 28336049
J Formos Med Assoc. 2014 Mar;113(3):155-60
pubmed: 24630032
Endocrinol Nutr. 2010 Feb;57(2):49-53
pubmed: 20149767
J Clin Endocrinol Metab. 2016 Apr;101(4):1754-61
pubmed: 26900641
Wien Med Wochenschr. 2016 Oct;166(13-14):424-430
pubmed: 27671008
Clin Endocrinol (Oxf). 2016 Apr;84(4):627-31
pubmed: 26662849
Med Princ Pract. 2020;29(4):364-370
pubmed: 31779003
Exp Biol Med (Maywood). 2007 Nov;232(10):1266-74
pubmed: 17959839
Asia Pac J Clin Nutr. 2016;25(2):221-6
pubmed: 27222404
Indian J Endocrinol Metab. 2012 Dec;16(Suppl 2):S361-3
pubmed: 23565429
Am J Clin Nutr. 2009 Feb;89(2):693S-6S
pubmed: 19116323
Am J Med Sci. 2006 Sep;332(3):119-22
pubmed: 16969140
N Engl J Med. 2013 Jan 10;368(2):149-60
pubmed: 23301732
Eur J Intern Med. 2015 Dec;26(10):825-9
pubmed: 26423749
Am J Hematol. 2016 Jan;91(1):31-8
pubmed: 26408108
J Clin Endocrinol Metab. 2014 Mar;99(3):923-31
pubmed: 24423323
N Engl J Med. 2018 Mar 22;378(12):1132-1141
pubmed: 29562162
Clin Gastroenterol Hepatol. 2008 Mar;6(3):314-20
pubmed: 18328437
Semin Hematol. 2015 Oct;52(4):261-9
pubmed: 26404438
Am J Clin Nutr. 2011 Jul;94(1):348S-358S
pubmed: 21593511
Indian J Med Res. 2013 Jan;137(1):82-6
pubmed: 23481055
Am J Clin Nutr. 2011 Aug;94(2):552-61
pubmed: 21677051
Acta Endocrinol (Buchar). 2017 Apr-Jun;13(2):174-179
pubmed: 31149170