Neurorrhaphy in Presence of Polyethylene Glycol Enables Immediate Electrophysiological Conduction in Porcine Model of Facial Nerve Injury.
axons
facial nerve injuries
facial paralysis
nerve fusion
nerve repair
peripheral nerve injuries
polyethylene glycol
swine
Journal
Frontiers in surgery
ISSN: 2296-875X
Titre abrégé: Front Surg
Pays: Switzerland
ID NLM: 101645127
Informations de publication
Date de publication:
2022
2022
Historique:
received:
09
11
2021
accepted:
24
01
2022
entrez:
28
3
2022
pubmed:
29
3
2022
medline:
29
3
2022
Statut:
epublish
Résumé
Facial nerve trauma often leads to disfiguring facial muscle paralysis. Despite several promising advancements, facial nerve repair procedures often do not lead to complete functional recovery. Development of novel repair strategies requires testing in relevant preclinical models that replicate key clinical features. Several studies have reported that fusogens, such as polyethylene glycol (PEG), can improve functional recovery by enabling immediate reconnection of injured axons; however, these findings have yet to be demonstrated in a large animal model. We first describe a porcine model of facial nerve injury and repair, including the relevant anatomy, surgical approach, and naive nerve morphometry. Next, we report positive findings from a proof-of-concept experiment testing whether a neurorrhaphy performed in conjunction with a PEG solution maintained electrophysiological nerve conduction at an acute time point in a large animal model. The buccal branch of the facial nerve was transected and then immediately repaired by direct anastomosis and PEG application. Immediate electrical conduction was recorded in the PEG-fused nerves (
Identifiants
pubmed: 35341161
doi: 10.3389/fsurg.2022.811544
pmc: PMC8948462
doi:
Types de publication
Journal Article
Langues
eng
Pagination
811544Informations de copyright
Copyright © 2022 Petrov, Burrell, Browne, Laimo, Roberts, Ali and Cullen.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Br J Hosp Med (Lond). 2016 Dec 2;77(12):686-691
pubmed: 27937022
J Extracell Vesicles. 2017 Jul 19;6(1):1344087
pubmed: 28804597
Brain Res. 1991 Oct 11;561(2):350-3
pubmed: 1802349
J Biomed Mater Res A. 2021 Jul;109(7):1183-1195
pubmed: 32985789
J Neurosci Res. 2017 Mar;95(3):863-866
pubmed: 27514994
J Neurosci Methods. 2019 Feb 15;314:1-12
pubmed: 30586569
J Neurosci Res. 2003 Nov 15;74(4):541-51
pubmed: 14598298
J Mater Sci Mater Med. 2015 Aug;26(8):226
pubmed: 26296419
Crit Rev Biomed Eng. 2011;39(2):81-124
pubmed: 21488817
J Neurosci. 1995 May;15(5 Pt 2):3876-85
pubmed: 7751952
J Neurosci Res. 2016 Mar;94(3):231-45
pubmed: 26728662
Exp Neurol. 2017 Jan;287(Pt 3):348-357
pubmed: 27094121
J Neurophysiol. 2010 Aug;104(2):695-703
pubmed: 20445038
Muscle Nerve. 2000 Jun;23(6):863-73
pubmed: 10842261
J Neurosci Res. 2012 May;90(5):967-80
pubmed: 22302646
News Physiol Sci. 2003 Jun;18:115-8
pubmed: 12750447
Expert Opin Drug Deliv. 2016 Sep;13(9):1257-75
pubmed: 27116988
Eur J Neurosci. 2016 Feb;43(3):271-86
pubmed: 26228942
Int Rev Neurobiol. 2009;87:141-72
pubmed: 19682637
Neural Regen Res. 2015 Sep;10(9):1406-8
pubmed: 26604897
Craniomaxillofac Trauma Reconstr. 2015 Mar;8(1):1-13
pubmed: 25709748
J Surg Res. 2012 Oct;177(2):392-400
pubmed: 22521220
Brain Res. 1986 Mar 5;367(1-2):351-5
pubmed: 3697710
Proc Natl Acad Sci U S A. 1990 Feb;87(4):1471-5
pubmed: 2304913
J Neurosci Res. 2018 Jul;96(7):1223-1242
pubmed: 29659058
J Neurosci Res. 2015 Apr;93(4):572-83
pubmed: 25425242
Neural Regen Res. 2021 Oct;16(10):2056-2063
pubmed: 33642394
Neurosurgery. 2020 Sep 15;87(4):833-846
pubmed: 32392341
J Neurosci. 1995 May;15(5 Pt 2):3886-95
pubmed: 7751953
Biomaterials. 2012 Nov;33(32):8034-9
pubmed: 22889485