Role of Microglia and Astrocytes in Spinal Cord Injury Induced Neuropathic Pain.
Astrocytes
JNK
Matrix metalloproteinases
Microglia
Neuropathic pain
P2 receptors
Spinal cord injury
Journal
Annals of neurosciences
ISSN: 0972-7531
Titre abrégé: Ann Neurosci
Pays: United States
ID NLM: 101523367
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
13
04
2021
accepted:
03
08
2021
entrez:
28
3
2022
pubmed:
29
3
2022
medline:
29
3
2022
Statut:
ppublish
Résumé
Spinal cord injuries incite varying degrees of symptoms in patients, ranging from weakness and incoordination to paralysis. Common amongst spinal cord injury (SCI) patients, neuropathic pain (NP) is a debilitating medical condition. Unfortunately, there remain many clinical impediments in treating NP because there is a lack of understanding regarding the mechanisms behind SCI-induced NP (SCINP). Given that more than 450,000 people in the United States alone suffer from SCI, it is unsatisfactory that current treatments yield poor results in alleviating and treating NP. In this review, we briefly discussed the models of SCINP along with the mechanisms of NP progression. Further, current treatment modalities are herein explored for SCINP involving pharmacological interventions targeting glia cells and astrocytes. The studies presented in this review provide insight for new directions regarding SCINP alleviation. Given the severity and incapacitating effects of SCINP, it is imperative to study the pathways involved and find new therapeutic targets in coordination with stem cell research, and to develop a new gold-standard in SCINP treatment.
Sections du résumé
Background
UNASSIGNED
Spinal cord injuries incite varying degrees of symptoms in patients, ranging from weakness and incoordination to paralysis. Common amongst spinal cord injury (SCI) patients, neuropathic pain (NP) is a debilitating medical condition. Unfortunately, there remain many clinical impediments in treating NP because there is a lack of understanding regarding the mechanisms behind SCI-induced NP (SCINP). Given that more than 450,000 people in the United States alone suffer from SCI, it is unsatisfactory that current treatments yield poor results in alleviating and treating NP.
Summary
UNASSIGNED
In this review, we briefly discussed the models of SCINP along with the mechanisms of NP progression. Further, current treatment modalities are herein explored for SCINP involving pharmacological interventions targeting glia cells and astrocytes.
Key message
UNASSIGNED
The studies presented in this review provide insight for new directions regarding SCINP alleviation. Given the severity and incapacitating effects of SCINP, it is imperative to study the pathways involved and find new therapeutic targets in coordination with stem cell research, and to develop a new gold-standard in SCINP treatment.
Identifiants
pubmed: 35341227
doi: 10.1177/09727531211046367
pii: 10.1177_09727531211046367
pmc: PMC8948321
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
219-228Informations de copyright
© 2021 Indian Academy of Neurosciences (IAN).
Déclaration de conflit d'intérêts
Declaration of Conflicting Interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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