Circulating biomarkers of inflammaging as potential predictors of COVID-19 severe outcomes.
Biomarkers
COVID-19
Inflammaging
Neutrophils
SARS-CoV-2
Journal
Mechanisms of ageing and development
ISSN: 1872-6216
Titre abrégé: Mech Ageing Dev
Pays: Ireland
ID NLM: 0347227
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
24
11
2021
revised:
22
03
2022
accepted:
22
03
2022
pubmed:
29
3
2022
medline:
14
5
2022
entrez:
28
3
2022
Statut:
ppublish
Résumé
The COVID-19 pandemic caused by SARS-CoV-2 infection has been of unprecedented clinical and socio-economic worldwide relevance. The case fatality rate for COVID-19 grows exponentially with age and the presence of comorbidities. In the older patients, COVID-19 manifests predominantly as a systemic disease associated with immunological, inflammatory, and procoagulant responses. Timely diagnosis and risk stratification are crucial steps to define appropriate therapies and reduce mortality, especially in the older patients. Chronically and systemically activated innate immune responses and impaired antiviral responses have been recognized as the results of a progressive remodeling of the immune system during aging, which can be described by the words 'immunosenescence' and 'inflammaging'. These age-related features of the immune system were highlighted in patients affected by COVID-19 with the poorest clinical outcomes, suggesting that the mechanisms underpinning immunosenescence and inflammaging could be relevant for COVID-19 pathogenesis and progression. Increasing evidence suggests that senescent myeloid and endothelial cells are characterized by the acquisition of a senescence-associated pro-inflammatory phenotype (SASP), which is considered as the main culprit of both immunosenescence and inflammaging. Here, we reviewed this evidence and highlighted several circulating biomarkers of inflammaging that could provide additional prognostic information to stratify COVID-19 patients based on the risk of severe outcomes.
Identifiants
pubmed: 35341896
pii: S0047-6374(22)00049-5
doi: 10.1016/j.mad.2022.111667
pmc: PMC8949647
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
111667Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.
Références
Angiogenesis. 2021 Aug;24(3):505-517
pubmed: 33449299
Nat Med. 2017 Nov 7;23(11):1384
pubmed: 29117172
Cells. 2021 Mar 12;10(3):
pubmed: 33808998
J Exp Med. 2008 Dec 22;205(13):3007-18
pubmed: 19064698
Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):878-882
pubmed: 33267656
Cell Death Dis. 2020 Oct 27;11(10):921
pubmed: 33110074
Protein Cell. 2020 Oct;11(10):740-770
pubmed: 32780218
Front Immunol. 2018 Mar 26;9:608
pubmed: 29632539
Front Immunol. 2020 Oct 14;11:580237
pubmed: 33154753
Mediators Inflamm. 2015;2015:816460
pubmed: 26089604
Nature. 2021 Jun;594(7861):100-105
pubmed: 33981041
Clin Appl Thromb Hemost. 2021 Jan-Dec;27:1076029621999099
pubmed: 33835872
Front Cardiovasc Med. 2021 Apr 16;8:653655
pubmed: 33937363
Best Pract Res Clin Rheumatol. 2021 Mar;35(1):101661
pubmed: 33526325
PLoS Pathog. 2009 Oct;5(10):e1000639
pubmed: 19876394
Ageing Res Rev. 2019 Mar;50:27-42
pubmed: 30615937
Allergy. 2021 Jun;76(6):1846-1858
pubmed: 33484168
Elife. 2020 Nov 26;9:
pubmed: 33241996
Front Mol Biosci. 2021 Apr 15;8:651662
pubmed: 33937333
Cancers (Basel). 2020 Jul 22;12(8):
pubmed: 32707943
Am J Pathol. 2011 Jul;179(1):199-210
pubmed: 21703402
Int J Infect Dis. 2020 Nov;100:34-41
pubmed: 32798659
Clin Immunol. 2007 Feb;122(2):220-8
pubmed: 17101294
Microvasc Res. 2021 Sep;137:104188
pubmed: 34022205
Front Immunol. 2019 Oct 22;10:2481
pubmed: 31695698
Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7326-7337
pubmed: 32170015
Infect Genet Evol. 2020 Nov;85:104422
pubmed: 32544615
J Immunol. 2015 May 1;194(9):4215-21
pubmed: 25825448
Biochim Biophys Acta. 2011 May;1813(5):878-88
pubmed: 21296109
Front Immunol. 2018 Oct 02;9:2171
pubmed: 30356867
Blood. 2020 Sep 3;136(10):1169-1179
pubmed: 32597954
J Med Virol. 2020 Oct;92(10):1733-1734
pubmed: 32242950
Sci Rep. 2021 Apr 8;11(1):7792
pubmed: 33833254
Viruses. 2020 Apr 26;12(5):
pubmed: 32357553
Thromb Res. 2020 Dec;196:67-74
pubmed: 32853978
Immunity. 2021 Jul 13;54(7):1578-1593.e5
pubmed: 34051147
Cell Host Microbe. 2012 Jul 19;12(1):109-16
pubmed: 22817992
mBio. 2020 Sep 18;11(5):
pubmed: 32948688
J Am Geriatr Soc. 2011 Sep;59(9):1679-85
pubmed: 21883115
Sci Signal. 2017 Dec 12;10(509):
pubmed: 29233916
Nat Rev Immunol. 2013 Jan;13(1):34-45
pubmed: 23222502
Life Sci. 1992;51(25):1953-6
pubmed: 1453878
Aging (Albany NY). 2016 Dec 7;8(12):3159-3160
pubmed: 27941213
Biomed Res Int. 2020 Jun 16;2020:6159720
pubmed: 32596339
Am J Respir Crit Care Med. 2009 Jul 15;180(2):159-66
pubmed: 19406984
Trends Cell Biol. 2018 Jun;28(6):436-453
pubmed: 29477613
Viruses. 2017 Oct 05;9(10):
pubmed: 28981470
Nat Rev Cardiol. 2018 Sep;15(9):505-522
pubmed: 30065258
Nature. 2009 Mar 26;458(7237):509-13
pubmed: 19158676
Commun Biol. 2022 Jan 12;5(1):45
pubmed: 35022513
Front Cell Infect Microbiol. 2021 Apr 15;11:646688
pubmed: 33937096
Nat Immunol. 2017 Jun;18(6):622-632
pubmed: 28459433
Shock. 2021 Dec 1;56(6):975-987
pubmed: 34033618
J Autoimmun. 2019 Mar;98:122-131
pubmed: 30704942
Am J Respir Crit Care Med. 2021 Jan 15;203(2):192-201
pubmed: 33217246
Lancet. 2021 May 01;397(10285):1637-1645
pubmed: 33933206
Immun Ageing. 2020 Jun 3;17:16
pubmed: 32518575
Front Immunol. 2020 Sep 23;11:560381
pubmed: 33072099
Int J Mol Sci. 2020 Jul 21;21(14):
pubmed: 32708334
Int Immunopharmacol. 2021 Sep;98:107806
pubmed: 34352471
Med Hypotheses. 2021 Jan;146:110448
pubmed: 33338955
J Allergy Clin Immunol. 2020 Jul;146(1):110-118
pubmed: 32294485
Nat Med. 2016 Feb;22(2):146-53
pubmed: 26779811
Nat Commun. 2021 Mar 5;12(1):1428
pubmed: 33674591
Autoimmun Rev. 2017 Nov;16(11):1160-1173
pubmed: 28899799
J Am Med Dir Assoc. 2013 Dec;14(12):877-82
pubmed: 23792036
Medicine (Baltimore). 2020 Nov 13;99(46):e23186
pubmed: 33181697
J Leukoc Biol. 2021 Jan;109(1):99-114
pubmed: 33617030
Front Immunol. 2016 Sep 19;7:366
pubmed: 27698656
Blood. 2013 Oct 17;122(16):2784-94
pubmed: 24009232
Rev Cardiovasc Med. 2020 Sep 30;21(3):315-319
pubmed: 33070537
Br J Dermatol. 2007 Dec;157(6):1124-31
pubmed: 17916212
Mediators Inflamm. 2021 Apr 1;2021:6635925
pubmed: 33833618
Mech Ageing Dev. 2020 Dec;192:111357
pubmed: 32949594
Int Immunol. 2020 Apr 12;32(4):223-231
pubmed: 31967307
Front Immunol. 2021 Jun 18;12:697405
pubmed: 34220859
Cells. 2020 Jun 02;9(6):
pubmed: 32498376
Blood. 2019 May 16;133(20):2178-2185
pubmed: 30898862
Blood. 2012 Nov 1;120(18):3699-707
pubmed: 22927244
J Extracell Vesicles. 2020 Feb 18;9(1):1725285
pubmed: 32158519
Viral Immunol. 2017 Mar;30(2):82-97
pubmed: 28051364
JAMA Netw Open. 2020 Feb 5;3(2):e200023
pubmed: 32101305
Front Pharmacol. 2020 Jul 17;11:1093
pubmed: 32765283
Blood Adv. 2021 Feb 9;5(3):628-634
pubmed: 33560376
Rev Med Virol. 2021 May;31(3):e2180
pubmed: 33022834
Trends Immunol. 2016 Sep;37(9):588-596
pubmed: 27345728
Biogerontology. 2018 Oct;19(5):325-339
pubmed: 29959657
Hum Immunol. 2011 Apr;72(4):319-29
pubmed: 21262312
Heliyon. 2021 Feb;7(2):e06155
pubmed: 33553782
Blood. 2008 Feb 1;111(3):1021-8
pubmed: 17989316
Exp Gerontol. 2017 Jan;87(Pt A):113-120
pubmed: 27931848
J Extracell Vesicles. 2020 Aug 6;9(1):1795365
pubmed: 32944185
Front Mol Biosci. 2021 Mar 18;8:600881
pubmed: 33816549
J Thromb Thrombolysis. 2020 Nov;50(4):814-821
pubmed: 32748122
Biochem Biophys Rep. 2021 Sep;27:101056
pubmed: 34151032
Immun Ageing. 2016 Jun 03;13:21
pubmed: 27274758
Med Clin (Barc). 2021 May 7;156(9):428-436
pubmed: 33627230
Expert Rev Respir Med. 2021 Aug;15(8):1061-1068
pubmed: 33905286
Inflamm Regen. 2018 Dec 24;38:24
pubmed: 30603051
Aging (Albany NY). 2021 Jan 11;13(1):1-15
pubmed: 33428591
Nat Chem Biol. 2013 Jul;9(7):455-61
pubmed: 23685671
Curr Pharm Des. 2018;24(10):1079-1091
pubmed: 29589544
Cytometry A. 2020 Aug;97(8):772-776
pubmed: 32542842
Brief Funct Genomics. 2022 Jan 25;21(1):43-55
pubmed: 33690792
J Thromb Haemost. 2021 Sep;19(9):2268-2274
pubmed: 34236752
Cell Immunol. 2021 Apr;362:104297
pubmed: 33550187
Nat Commun. 2020 Jan 8;11(1):105
pubmed: 31913271
J Thromb Haemost. 2020 Sep;18(9):2215-2219
pubmed: 32668058
Aging Cell. 2020 Oct;19(10):e13230
pubmed: 33006233
Front Immunol. 2019 Jan 29;10:111
pubmed: 30761152
PLoS One. 2020 Oct 20;15(10):e0240012
pubmed: 33079950
J Exp Med. 2020 Dec 7;217(12):
pubmed: 32926098
Arch Pathol Lab Med. 2022 Jan 1;146(1):34-37
pubmed: 34546331
J Immunol. 2021 Apr 1;206(7):1597-1608
pubmed: 33579725
Int Immunopharmacol. 2021 Jan;90:107233
pubmed: 33290963
Nat Immunol. 2020 Dec;21(12):1506-1516
pubmed: 33028979
Nature. 2014 May 22;509(7501):439-46
pubmed: 24848057
EBioMedicine. 2021 May;67:103357
pubmed: 33979758
Aging (Albany NY). 2020 Oct 26;12(20):19911-19922
pubmed: 33104521
J Extracell Vesicles. 2015 Mar 13;4:26901
pubmed: 25773446
Front Pharmacol. 2020 Oct 09;11:572009
pubmed: 33162887
Front Immunol. 2021 Oct 29;12:697622
pubmed: 34777333
PLoS Biol. 2008 Dec 2;6(12):2853-68
pubmed: 19053174
Front Public Health. 2020 May 28;8:232
pubmed: 32671009
FASEB J. 2020 Jun;34(6):7247-7252
pubmed: 32427393
Immun Ageing. 2008 Jul 25;5:6
pubmed: 18657274
Front Immunol. 2021 Apr 14;12:656700
pubmed: 33936086
J Infect Dis. 2020 Jun 16;222(1):34-37
pubmed: 32348495
Front Immunol. 2018 Jan 10;8:1960
pubmed: 29375577
Cancer Lett. 2016 Oct 10;381(1):156-64
pubmed: 27431309
JCI Insight. 2021 Aug 9;6(15):
pubmed: 34166229
Sci Transl Med. 2011 Mar 9;3(73):73ra19
pubmed: 21389263
Ther Adv Respir Dis. 2021 Jan-Dec;15:17534666211049739
pubmed: 34632871
Science. 2004 Mar 5;303(5663):1532-5
pubmed: 15001782
Front Immunol. 2020 Oct 27;11:579220
pubmed: 33193377
Front Immunol. 2016 Aug 15;7:311
pubmed: 27574522
Front Immunol. 2020 Oct 06;11:573662
pubmed: 33123152
Front Cell Infect Microbiol. 2021 Sep 10;11:694186
pubmed: 34568088
Oncogene. 2013 Apr 11;32(15):1971-7
pubmed: 22751116
Res Pract Thromb Haemost. 2018 Nov 20;3(1):44-48
pubmed: 30656275
Indian J Crit Care Med. 2021 Aug;25(8):847-852
pubmed: 34733022
Circulation. 2021 Mar 9;143(10):971-973
pubmed: 33434052
J Clin Invest. 2020 Nov 2;130(11):6151-6157
pubmed: 32759504
J Am Geriatr Soc. 2021 Dec;69(12):3377-3388
pubmed: 34409590
Expert Rev Clin Immunol. 2021 May;17(5):431-443
pubmed: 33750254
EClinicalMedicine. 2021 Sep;39:101069
pubmed: 34377969
Front Immunol. 2012 Oct 04;3:307
pubmed: 23060885
Paediatr Respir Rev. 2020 Sep;35:20-24
pubmed: 32653469
Thromb Haemost. 2021 Sep;121(9):1138-1150
pubmed: 33352593
Cytokine Growth Factor Rev. 2020 Jun;53:33-37
pubmed: 32389499
Handb Exp Pharmacol. 2008;(183):71-86
pubmed: 18071655
J Clin Pharm Ther. 2020 Dec;45(6):1515-1519
pubmed: 32860252
Nat Rev Immunol. 2020 Jun;20(6):355-362
pubmed: 32376901
Cells. 2020 Jul 21;9(7):
pubmed: 32708331
RNA Biol. 2021 May;18(5):688-695
pubmed: 33530819
Virus Res. 2018 Jun 2;251:68-77
pubmed: 29621602
PLoS One. 2021 Feb 26;16(2):e0247605
pubmed: 33635872
J Thromb Haemost. 2020 Oct;18(10):2646-2653
pubmed: 32762118
Nat Med. 2007 Sep;13(9):1042-9
pubmed: 17767165
Ageing Res Rev. 2017 Jul;36:125-136
pubmed: 28396185
Front Genet. 2013 Jun 26;4:121
pubmed: 23805154
J Leukoc Biol. 2021 Jan;109(1):67-72
pubmed: 32869342
Science. 2020 Aug 21;369(6506):
pubmed: 32820093
Front Med (Lausanne). 2021 Feb 23;8:615984
pubmed: 33708778
Crit Care. 2020 Jun 8;24(1):311
pubmed: 32513225
Front Immunol. 2021 Feb 26;12:627548
pubmed: 33777012
Front Immunol. 2018 Sep 12;9:1936
pubmed: 30279686
Int J Infect Dis. 2022 Apr;117:267-273
pubmed: 34192577
Med Hypotheses. 2021 Oct;155:110646
pubmed: 34392108
J Clin Invest. 2021 Dec 15;131(24):
pubmed: 34710063
Int J Mol Sci. 2021 Apr 29;22(9):
pubmed: 33946935
Eur J Clin Invest. 2020 Oct;50(10):e13376
pubmed: 32880939
Nature. 2015 Sep 24;525(7570):528-32
pubmed: 26374999
Immunogenetics. 2020 Oct;72(8):431-437
pubmed: 33067641
EMBO J. 2021 May 3;40(9):e106048
pubmed: 33764576
Life Sci. 2020 Sep 15;257:118102
pubmed: 32687918
Cell Tissue Res. 2018 Mar;371(3):473-488
pubmed: 29250748
Ageing Res Rev. 2018 Dec;48:1-10
pubmed: 30248408
J Clin Invest. 2012 Jul;122(7):2661-71
pubmed: 22684106
J Cyst Fibros. 2020 Mar;19(2):299-304
pubmed: 31501052
Proc Natl Acad Sci U S A. 2020 May 19;117(20):10970-10975
pubmed: 32350134
Nat Rev Immunol. 2011 Jul 25;11(8):519-31
pubmed: 21785456
J Thromb Thrombolysis. 2022 Jan;53(1):83-87
pubmed: 33982161
Front Immunol. 2020 May 01;11:827
pubmed: 32425950
J Immunol Res. 2019 Mar 12;2019:2160192
pubmed: 30993117
Blood. 2005 Mar 15;105(6):2294-9
pubmed: 15572589
Haematologica. 2021 Jun 01;106(6):1636-1646
pubmed: 32586906
Proteins. 2022 May;90(5):1029-1043
pubmed: 34333809
Semin Immunopathol. 2019 Jan;41(1):125-131
pubmed: 30006738
J Clin Invest. 2020 Sep 1;130(9):4694-4703
pubmed: 32463803
Viruses. 2021 May 21;13(6):
pubmed: 34064104
Clin Microbiol Infect. 2021 Aug;27(8):1076-1082
pubmed: 33915284
J Gerontol A Biol Sci Med Sci. 2021 Jul 13;76(8):e97-e101
pubmed: 33528568
Cell Rep. 2020 May 5;31(5):107602
pubmed: 32375035
Cells. 2021 Sep 26;10(10):
pubmed: 34685525
EBioMedicine. 2021 Aug;70:103485
pubmed: 34304048
Front Immunol. 2017 Aug 28;8:1003
pubmed: 28894445
J Clin Invest. 2021 Mar 15;131(6):
pubmed: 33492309
Cytokine Growth Factor Rev. 2012 Jun;23(3):85-97
pubmed: 22595692
Mech Ageing Dev. 2021 Jan;193:111413
pubmed: 33307107
Lymphokine Cytokine Res. 1993 Aug;12(4):225-30
pubmed: 8218595
J Autoimmun. 2020 Jul;111:102452
pubmed: 32291137
Thromb J. 2020 Nov 23;18(1):34
pubmed: 33292258
ACS Infect Dis. 2021 Jun 11;7(6):1545-1554
pubmed: 33849267
Semin Immunol. 2018 Dec;40:101275
pubmed: 31088710
Blood. 2020 Jan 16;135(3):167-180
pubmed: 31805184
Int Immunopharmacol. 2021 Aug;97:107641
pubmed: 33895478
World J Diabetes. 2021 May 15;12(5):590-602
pubmed: 33995847
Int Immunopharmacol. 2020 Feb;79:106057
pubmed: 31877496
Front Microbiol. 2019 May 10;10:1057
pubmed: 31134045
Cell. 2020 Sep 17;182(6):1419-1440.e23
pubmed: 32810438
Cell. 2020 Sep 17;182(6):1401-1418.e18
pubmed: 32810439
JCI Insight. 2020 Jun 4;5(11):
pubmed: 32329756
Ann Intensive Care. 2021 Mar 22;11(1):50
pubmed: 33751264
Crit Care Med. 2013 Mar;41(3):820-32
pubmed: 23348516
Arthritis Rheum. 2007 Sep;56(9):3044-56
pubmed: 17763423
Sci Rep. 2021 Jan 15;11(1):1580
pubmed: 33452298
Cell Mol Immunol. 2020 Oct;17(10):1101-1103
pubmed: 32879471
Front Cardiovasc Med. 2019 Jun 20;6:85
pubmed: 31281822
Clin Chem Lab Med. 2020 Nov 26;59(3):599-607
pubmed: 33554561
J Cell Biol. 2007 Jan 15;176(2):231-41
pubmed: 17210947
J Clin Invest. 2021 Apr 15;131(8):
pubmed: 33635833
JAMA Netw Open. 2020 Mar 2;3(3):e203976
pubmed: 32202646
CMAJ. 2013 Nov 5;185(16):E763-70
pubmed: 24043651
J Clin Med. 2021 Apr 09;10(8):
pubmed: 33918563
Ann N Y Acad Sci. 2006 Nov;1089:487-95
pubmed: 17261791
J Infect Dis. 2021 Aug 2;224(3):395-406
pubmed: 33493287
Front Immunol. 2021 Oct 04;12:741502
pubmed: 34671355
Cell. 2017 Nov 16;171(5):1110-1124.e18
pubmed: 29033128
Cell Tissue Res. 2018 Mar;371(3):505-516
pubmed: 29327081
Int J Hematol. 2021 Jan;113(1):45-57
pubmed: 33161508
J Exp Med. 2010 Sep 27;207(10):2187-94
pubmed: 20819927
Nature. 2008 Oct 2;455(7213):674-8
pubmed: 18724357
ACS Omega. 2021 Mar 05;6(10):7181-7185
pubmed: 33748632
J Clin Med. 2021 Oct 19;10(20):
pubmed: 34682920
Cell Metab. 2021 Feb 2;33(2):258-269.e3
pubmed: 33421384
PLoS Comput Biol. 2021 Mar 8;17(3):e1008810
pubmed: 33684134
J Immunol. 2017 Aug 15;199(4):1405-1417
pubmed: 28696254
Chest. 2021 Mar;159(3):1182-1196
pubmed: 33217420
Cancer Immunol Res. 2014 Apr;2(4):288-94
pubmed: 24764575
Ann N Y Acad Sci. 2000 Jun;908:244-54
pubmed: 10911963
Int Immunol. 2021 Mar 31;33(4):241-247
pubmed: 33538817
Transl Res. 2021 Oct;236:147-159
pubmed: 34048985
Aging (Albany NY). 2018 Jun 08;10(6):1268-1280
pubmed: 29885276
Front Immunol. 2020 Aug 07;11:1748
pubmed: 32849623
J Gerontol A Biol Sci Med Sci. 2014 Feb;69(2):165-73
pubmed: 23689826
J Infect Dis. 2021 May 20;223(9):1503-1505
pubmed: 33503244
Wellcome Open Res. 2021 Feb 22;6:38
pubmed: 33997298
Exp Gerontol. 2018 Jul 1;107:55-58
pubmed: 28687479
J Am Coll Nutr. 2021 Sep-Oct;40(7):632-645
pubmed: 32870735
Clin Rev Allergy Immunol. 2023 Apr;64(2):109-122
pubmed: 34536213
J Mol Med (Berl). 2021 Jan;99(1):1-20
pubmed: 33025106
Clin Exp Allergy. 2019 Jul;49(7):990-999
pubmed: 31046155
Curr Genomics. 2012 Dec;13(8):589-602
pubmed: 23730199
J Thromb Thrombolysis. 2021 Oct;52(3):746-753
pubmed: 34110529
Cell Death Differ. 2019 Mar;26(3):395-408
pubmed: 30622307
Cell Mol Immunol. 2021 Mar;18(3):604-612
pubmed: 33060840