Histological endpoints and oxidative stress transcriptional responses in the Mediterranean mussel Mytilus galloprovincialis exposed to realistic doses of salicylic acid.

Animals Biomarkers / metabolism Mytilus / metabolism Oxidative Stress / physiology Salicylic Acid / toxicity Seafood Water Pollutants, Chemical / analysis
Catalase Cu-Zn superoxide dismutase Glutathione S-transferase Mn superoxide dismutase Mussel digestive gland Pharmaceutically active compounds (PhACs)

Journal

Environmental toxicology and pharmacology
ISSN: 1872-7077
Titre abrégé: Environ Toxicol Pharmacol
Pays: Netherlands
ID NLM: 9612020

Informations de publication

Date de publication:
May 2022
Historique:
received: 29 07 2021
revised: 23 09 2021
accepted: 21 03 2022
pubmed: 29 3 2022
medline: 14 5 2022
entrez: 28 3 2022
Statut: ppublish

Résumé

Despite the availability of analytic data, little is known about the toxicity of salicylic acid (SA) on aquatic non-target organisms. The present study aimed at evaluating the impact of SA through a short-term exposure of the Mediterranean mussel Mytilus galloprovincialis to five environmentally relevant concentrations of SA. A set of suitable biomarkers was applied at selected time-points on mussel digestive glands, including histological observations and expression of oxidative stress related genes. The obtained results showed a conspicuous hemocytic infiltration among mussel digestive tubules, as confirmed also by a flow cytometric approach that revealed an increase of halinocytes and granulocytes. Interestingly, a significant dose and time dependent decrease in the expression levels of oxidative stress related genes was found in mussels exposed to SA except for the glutathione S-transferase gene that was significantly up-regulated in a time-dependent manner confirming its important role against oxidant species and in the metabolism of pharmaceuticals.

Identifiants

DOI: 10.1016/j.etap.2022.103855 PMID: 35342010
pubmed: 35342010
pii: S1382-6689(22)00048-5
doi: 10.1016/j.etap.2022.103855
pii:
doi:

Substances chimiques

Biomarkers 0
Water Pollutants, Chemical 0
Salicylic Acid O414PZ4LPZ

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

103855

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Auteurs

Sabrine Afsa (S)

Research Unit of Analysis and Process Applied to The Environment - APAE (UR17ES32) Higher Institute of Applied Sciences and Technology of Mahdia, University of Monastir, Monastir 5000, Tunisia; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina 98166, Italy.

Giuseppe De Marco (G)

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina 98166, Italy.

Alessia Giannetto (A)

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina 98166, Italy.

Vincenzo Parrino (V)

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina 98166, Italy.

Tiziana Cappello (T)

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina 98166, Italy. Electronic address: tcappello@unime.it.

Hedi Ben Mansour (H)

Research Unit of Analysis and Process Applied to The Environment - APAE (UR17ES32) Higher Institute of Applied Sciences and Technology of Mahdia, University of Monastir, Monastir 5000, Tunisia.

Maria Maisano (M)

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina 98166, Italy.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Histological endpoints and oxidative stress...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Histological endpoints and oxidative stress...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Mollusca › Bivalvia › Mytilidae › Mytilus › Histological endpoints and oxidative stress...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Histological endpoints and oxidative stress...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Hydroxybenzoates › Salicylates › Acide salicylique › Histological endpoints and oxidative stress...
questionsmedicales.fr › Aliments et boissons › Aliments › Viande › Produits de la mer › Histological endpoints and oxidative stress...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › Polluants de l'eau › Polluants chimiques de l'eau › Histological endpoints and oxidative stress...