Specific overexpression of SIRT1 in mesenchymal stem cells rescues hematopoiesis niche in BMI1 knockout mice through promoting CXCL12 expression.
Bmi1
CXCL12.
Sirt1
hematopoietic stem cell niche
mesenchymal progenitor cells
Journal
International journal of biological sciences
ISSN: 1449-2288
Titre abrégé: Int J Biol Sci
Pays: Australia
ID NLM: 101235568
Informations de publication
Date de publication:
2022
2022
Historique:
received:
15
06
2021
accepted:
08
02
2022
entrez:
28
3
2022
pubmed:
29
3
2022
medline:
16
4
2022
Statut:
epublish
Résumé
Osteoblastic lineage cells (OBCs) are bone-building cells and essential component of hematopoietic niche, but mechanisms whereby bone-building and hematopoiesis-supportive activities of OBCs could be regulated simultaneously remain largely unknown. Here we found that B cell-specific Moloney murine leukemia virus integration site 1 (Bmi1) was involved in such a co-regulatory mechanism. In this study, we first found that, accompanied with marked decline of osteogenic activity, the hematopoietic niche in Bmi1 knockout (KO) mice was severely impaired and manifested as CXCL12 expression falls and LSK homing failure; however, intratibial injection with CXCL12 effectively facilitated LSK accumulation in bone marrow of Bmi1 KO mice. To try to rescue these defects in Bmi1 KO mice, we generated Bmi1
Identifiants
pubmed: 35342358
doi: 10.7150/ijbs.63876
pii: ijbsv18p2091
pmc: PMC8935221
doi:
Substances chimiques
Bmi1 protein, mouse
0
Chemokine CXCL12
0
Cxcl12 protein, mouse
0
Proto-Oncogene Proteins
0
Polycomb Repressive Complex 1
EC 2.3.2.27
Sirt1 protein, mouse
EC 3.5.1.-
Sirtuin 1
EC 3.5.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2091-2103Informations de copyright
© The author(s).
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
Références
Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20012-7
pubmed: 22123971
Blood. 2011 Jan 13;117(2):429-39
pubmed: 20833981
J Nucl Med. 2008 Jun;49(6):963-9
pubmed: 18483105
J Biomed Res. 2012 Sep;26(5):355-64
pubmed: 23554771
Nat Rev Drug Discov. 2006 Jun;5(6):493-506
pubmed: 16732220
Am J Pathol. 2006 Aug;169(2):338-46
pubmed: 16877336
Nature. 2004 Mar 18;428(6980):337-41
pubmed: 15029199
Curr Opin Hematol. 2010 Jul;17(4):319-26
pubmed: 20473162
Nature. 2011 Sep 21;477(7365):482-5
pubmed: 21938067
Cell. 2004 Jul 23;118(2):149-61
pubmed: 15260986
Nature. 2005 Feb 17;433(7027):760-4
pubmed: 15716955
Blood. 2010 Dec 9;116(24):5140-8
pubmed: 20826722
PLoS One. 2014 Apr 04;9(4):e93864
pubmed: 24705625
Front Pharmacol. 2018 Nov 20;9:1261
pubmed: 30524273
Metabolism. 2018 Nov;88:61-71
pubmed: 30318050
Blood. 2011 Oct 20;118(16):4431-9
pubmed: 21868571
J Exp Med. 2006 Oct 2;203(10):2247-53
pubmed: 16954369
Nature. 2010 Jan 28;463(7280):495-500
pubmed: 20110993
Blood. 2009 Aug 20;114(8):1498-505
pubmed: 19556423
EMBO Mol Med. 2013 Mar;5(3):430-40
pubmed: 23364955
Oncogene. 2006 Jul 20;25(31):4370-5
pubmed: 16501599
Genes Dev. 1994 Apr 1;8(7):757-69
pubmed: 7926765
J Biol Chem. 2014 Aug 29;289(35):24069-78
pubmed: 25002589
J Bone Miner Res. 2010 Mar;25(3):640-52
pubmed: 19653817
Stem Cell Res. 2015 Jul;15(1):130-40
pubmed: 26046330
Semin Hematol. 2017 Jan;54(1):25-32
pubmed: 28088984
Nature. 2000 Feb 17;403(6771):795-800
pubmed: 10693811
Nature. 2013 Mar 14;495(7440):227-30
pubmed: 23434756
J Exp Med. 2005 Apr 18;201(8):1307-18
pubmed: 15837815
Nature. 2006 Nov 16;444(7117):337-42
pubmed: 17086191
Nat Cell Biol. 2013 Apr;15(4):353-62
pubmed: 23502315
Aging (Albany NY). 2013 Sep;5(9):682-91
pubmed: 24036492
Nature. 2003 May 15;423(6937):302-5
pubmed: 12714971
J Bone Miner Res. 2010 Jul;25(7):1468-86
pubmed: 20533309
Nature. 2004 Aug 5;430(7000):686-9
pubmed: 15254550
Sci Rep. 2017 Feb 01;7:41358
pubmed: 28145497
Sci Rep. 2016 Jul 04;6:29171
pubmed: 27373231
Cell Cycle. 2012 Jan 1;11(1):65-78
pubmed: 22185780
Biol Lett. 2012 Oct 23;8(5):790-3
pubmed: 22718956