Prevalence of nephrocalcinosis in children with congenital adrenal hyperplasia.
Congenital adrenal hyperplasia
nephrocalcinosis
prevalence
Journal
Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences
ISSN: 1735-1995
Titre abrégé: J Res Med Sci
Pays: India
ID NLM: 101235599
Informations de publication
Date de publication:
2022
2022
Historique:
received:
02
10
2021
revised:
20
01
2022
accepted:
26
01
2022
entrez:
28
3
2022
pubmed:
29
3
2022
medline:
29
3
2022
Statut:
epublish
Résumé
We aimed to investigate the prevalence of nephrocalcinosis (NC) among children with diagnosed congenital adrenal hyperplasia (CAH). Our findings would be helpful for earlier diagnosis, management, and prevention of NC-related complications. In this cross-sectional study, children with CAH, aged <18 years old who were regularly referred for follow-up, were included. The information of the patients was extracted from their medical files, and they underwent renal ultrasonography for evaluation of the presence of NC. From 120 studied patients with CAH, four patients (3.3%) had NC. The prevalence of NC was higher in males than females ( The results of this study indicated a 3.3% prevalence rate of NC for children with CAH. NC had a trend to be more prevalent in male children with CAH. Though it was not significantly different but given that the mean age and age at diagnosis of CAH in children with CAH and NC was lower that CAH patients without NC, it is suggested that in patients with CAH and NC other factors such as genetic background or unknown disease related factors are associated with hypercalcemia and NC.
Sections du résumé
Background
UNASSIGNED
We aimed to investigate the prevalence of nephrocalcinosis (NC) among children with diagnosed congenital adrenal hyperplasia (CAH). Our findings would be helpful for earlier diagnosis, management, and prevention of NC-related complications.
Materials and Methods
UNASSIGNED
In this cross-sectional study, children with CAH, aged <18 years old who were regularly referred for follow-up, were included. The information of the patients was extracted from their medical files, and they underwent renal ultrasonography for evaluation of the presence of NC.
Results
UNASSIGNED
From 120 studied patients with CAH, four patients (3.3%) had NC. The prevalence of NC was higher in males than females (
Conclusion
UNASSIGNED
The results of this study indicated a 3.3% prevalence rate of NC for children with CAH. NC had a trend to be more prevalent in male children with CAH. Though it was not significantly different but given that the mean age and age at diagnosis of CAH in children with CAH and NC was lower that CAH patients without NC, it is suggested that in patients with CAH and NC other factors such as genetic background or unknown disease related factors are associated with hypercalcemia and NC.
Identifiants
pubmed: 35342446
doi: 10.4103/jrms.jrms_872_21
pii: JRMS-27-16
pmc: PMC8943593
doi:
Types de publication
Journal Article
Langues
eng
Pagination
16Informations de copyright
Copyright: © 2022 Journal of Research in Medical Sciences.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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