Pulmonary amyloidosis as the presenting finding in a patient with multiple myeloma.
Case report
Light chain (AL) amyloidosis
Multiple myeloma
Pulmonary amyloidosis
Journal
Respiratory medicine case reports
ISSN: 2213-0071
Titre abrégé: Respir Med Case Rep
Pays: England
ID NLM: 101604463
Informations de publication
Date de publication:
2022
2022
Historique:
received:
19
10
2021
revised:
19
02
2022
accepted:
07
03
2022
entrez:
28
3
2022
pubmed:
29
3
2022
medline:
29
3
2022
Statut:
epublish
Résumé
We present the case of a 58-year-old man who presented with dyspnea, cough, and weight loss and was ultimately diagnosed with pulmonary amyloidosis and multiple myeloma. Diagnosis was achieved with a lung biopsy which showed AL amyloid deposits involving the interstitium, vessels, and airway. He was treated with cyclophosphamide, bortezomib, and dexamethasone but died prior to completing treatment. His case is unique for the amyloid deposition found in all three lung compartments with clear pathophysiologic manifestations of each compartment, and the rapid disease progression that led to respiratory failure and death.
Identifiants
pubmed: 35342704
doi: 10.1016/j.rmcr.2022.101626
pii: S2213-0071(22)00048-X
pmc: PMC8943293
doi:
Types de publication
Case Reports
Langues
eng
Pagination
101626Informations de copyright
© 2022 The Authors. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
RH reports receiving the following: indirect clinical trial research funding from Boehringer Ingelheim, Regeneron, and Galapagos; authorship fees from Dynamed and Wolters Kluwer; consulting fees from Teladoc, ImpactNetwork, Boehringer Ingelheim, and Paradigm Medical; advisory board meeting fees from Boehringer Ingelheim. PVL has received consulting fees from Gala Therapeutics, Intuitive Surgical, and Galvanize Therapeutics, unrelated to the current work. All other authors report no conflicts of interest.
Références
Radiographics. 2015 Sep-Oct;35(5):1381-92
pubmed: 26230754
Chest. 2001 Nov;120(5):1735-8
pubmed: 11713162
Int J Cardiol. 2007 Jan 31;115(1):e29-30
pubmed: 17049643
J Gen Intern Med. 2007 Mar;22(3):416-9
pubmed: 17356978
Am J Surg Pathol. 2007 Feb;31(2):267-76
pubmed: 17255772
Eur Respir Rev. 2017 Sep 6;26(145):
pubmed: 28877975
Chest. 1978 Nov;74(5):543-7
pubmed: 104830
Malays J Pathol. 1999 Jun;21(1):29-35
pubmed: 10879276
Int J Clin Exp Pathol. 2015 Nov 01;8(11):15391-5
pubmed: 26823900
N Engl J Med. 2003 Aug 7;349(6):583-96
pubmed: 12904524
Respir Med Case Rep. 2021 Mar 19;33:101400
pubmed: 33854940
Pulm Circ. 2016 Jun;6(2):244-8
pubmed: 27252852
Am J Respir Crit Care Med. 2020 Jan 1;201(1):107-108
pubmed: 31348688
Tuberk Toraks. 2006;54(1):65-70
pubmed: 16615021
BMC Cancer. 2018 Aug 8;18(1):802
pubmed: 30089469
Lung. 2015 Dec;193(6):875-83
pubmed: 26310967
Respirology. 2001 Mar;6(1):61-4
pubmed: 11264765