Knockout of Stearoyl-CoA Desaturase 1 Decreased Milk Fat and Unsaturated Fatty Acid Contents of the Goat Model Generated by CRISPR/Cas9.

Animals CRISPR-Cas Systems Fatty Acids / metabolism Fatty Acids, Unsaturated / metabolism Goats / metabolism Milk / chemistry Stearoyl-CoA Desaturase / genetics
CRISPR/Cas9 fatty acids goat milk lipidomics stearoyl-CoA desaturase 1

Journal

Journal of agricultural and food chemistry
ISSN: 1520-5118
Titre abrégé: J Agric Food Chem
Pays: United States
ID NLM: 0374755

Informations de publication

Date de publication:
06 Apr 2022
Historique:
pubmed: 29 3 2022
medline: 8 4 2022
entrez: 28 3 2022
Statut: ppublish

Résumé

Goat milk contains a rich source of nutrients, especially unsaturated fatty acids. However, the regulatory mechanism of milk fat and fatty acid synthesis remains unclear. Stearoyl-CoA desaturase 1 (SCD1) is the key enzyme catalyzing monounsaturated fatty acid synthesis and is essential for milk lipid metabolism. To explore milk lipid synthesis mechanism

Identifiants

DOI: 10.1021/acs.jafc.2c00642 PMID: 35343224
pubmed: 35343224
doi: 10.1021/acs.jafc.2c00642
doi:

Substances chimiques

Fatty Acids 0
Fatty Acids, Unsaturated 0
Stearoyl-CoA Desaturase EC 1.14.19.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

4030-4043

Auteurs

Huibin Tian (H)

Shaanxi Key Laboratory of Molecular Biology for Agriculture, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.

Huimin Niu (H)

Shaanxi Key Laboratory of Molecular Biology for Agriculture, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.

Jun Luo (J)

Shaanxi Key Laboratory of Molecular Biology for Agriculture, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.
ORCID: 0000-0002-2597-3613

Weiwei Yao (W)

Shaanxi Key Laboratory of Molecular Biology for Agriculture, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.

Xiaoying Chen (X)

Shaanxi Key Laboratory of Molecular Biology for Agriculture, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.

Jiao Wu (J)

Shaanxi Key Laboratory of Molecular Biology for Agriculture, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.

Yanan Geng (Y)

Shaanxi Key Laboratory of Molecular Biology for Agriculture, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.

Wenchang Gao (W)

Shaanxi Key Laboratory of Molecular Biology for Agriculture, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.

Anmin Lei (A)

College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China.

Zhimin Gao (Z)

College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China.

Xiue Tian (X)

Shaanxi Key Laboratory of Molecular Biology for Agriculture, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.

Xiaoe Zhao (X)

College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China.

Huaiping Shi (H)

Shaanxi Key Laboratory of Molecular Biology for Agriculture, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.
ORCID: 0000-0003-0476-7615

Cong Li (C)

Shaanxi Key Laboratory of Molecular Biology for Agriculture, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.

Jinlian Hua (J)

College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Knockout of Stearoyl-CoA Desaturase 1...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Systèmes CRISPR-Cas › Knockout of Stearoyl-CoA Desaturase 1...
questionsmedicales.fr › Lipides › Acides gras › Knockout of Stearoyl-CoA Desaturase 1...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Knockout of Stearoyl-CoA Desaturase 1...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Capra › Knockout of Stearoyl-CoA Desaturase 1...
questionsmedicales.fr › Aliments et boissons › Aliments › Produits laitiers › Lait › Knockout of Stearoyl-CoA Desaturase 1...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Mixed function oxygenases › Fatty acid desaturases › Acyl-(acyl-carrier-protein)desaturase › Knockout of Stearoyl-CoA Desaturase 1...