Genomic Surveillance of Vancomycin-Resistant Enterococcus faecium Reveals Spread of a Linear Plasmid Conferring a Nutrient Utilization Advantage.
Enterococcus faecium
N-acetyl-galactosamine
horizontal gene transfer
linear plasmid
transmission networks
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
26 04 2022
26 04 2022
Historique:
pubmed:
29
3
2022
medline:
29
4
2022
entrez:
28
3
2022
Statut:
ppublish
Résumé
Healthcare-associated outbreaks of vancomycin-resistant Enterococcus faecium (VREfm) are a worldwide problem with increasing prevalence. The genomic plasticity of this hospital-adapted pathogen contributes to its efficient spread despite infection control measures. Here, we aimed to identify the genomic and phenotypic determinants of health care-associated transmission of VREfm. We assessed the VREfm transmission networks at the tertiary-care University Hospital of Zurich (USZ) between October 2014 and February 2018 and investigated microevolutionary dynamics of this pathogen. We performed whole-genome sequencing for the 69 VREfm isolates collected during this time frame and assessed the population structure and variability of the vancomycin resistance transposon. Phylogenomic analysis allowed us to reconstruct transmission networks and to unveil external or wider transmission networks undetectable by routine surveillance. Notably, it unveiled a
Identifiants
pubmed: 35343787
doi: 10.1128/mbio.03771-21
pmc: PMC9040824
doi:
Substances chimiques
Vancomycin
6Q205EH1VU
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0377121Subventions
Organisme : UZH, Clinical Research Priority Program
ID : Precision Medicine for Bacterial Infections
Organisme : Swiss National Science Foundation
ID : 31003A_176252
Pays : Switzerland
Commentaires et corrections
Type : CommentIn
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