Machupo Virus with Mutations in the Transmembrane Domain and Glycosylation Sites of the Glycoprotein Is Attenuated and Immunogenic in Animal Models of Bolivian Hemorrhagic Fever.
Machupo virus
animal models
arenavirus
pathogenesis
vaccines
virulence
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
27 04 2022
27 04 2022
Historique:
pubmed:
29
3
2022
medline:
30
4
2022
entrez:
28
3
2022
Statut:
ppublish
Résumé
Several highly pathogenic mammarenaviruses cause severe hemorrhagic and neurologic disease in humans for which vaccines and antivirals are limited or unavailable. New World (NW) mammarenavirus Machupo virus (MACV) infection causes Bolivian hemorrhagic fever in humans. We previously reported that the disruption of specific N-linked glycan sites on the glycoprotein (GPC) partially attenuates MACV in an interferon alpha/beta and gamma (IFN-α/β and -γ) receptor knockout (R
Identifiants
pubmed: 35343792
doi: 10.1128/jvi.00209-22
pmc: PMC9044957
doi:
Substances chimiques
Glycoproteins
0
Vaccines, Attenuated
0
Viral Vaccines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0020922Subventions
Organisme : NIAID NIH HHS
ID : R01 AI093445
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR001440
Pays : United States
Organisme : NIAID NIH HHS
ID : K99 AI156012
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI060549
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI129198
Pays : United States
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