Antidepressant activity of phytochemicals of Mangifera indica seeds assisted by integrated computational analysis.
ADMET
Antidepressant
Forced swing test
Mangifera indica
Molecular docking
Phytomedicine
Tail suspension test
Journal
Metabolic brain disease
ISSN: 1573-7365
Titre abrégé: Metab Brain Dis
Pays: United States
ID NLM: 8610370
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
02
11
2021
accepted:
09
03
2022
pubmed:
29
3
2022
medline:
25
1
2023
entrez:
28
3
2022
Statut:
ppublish
Résumé
Mangifera indica L., also known as mango, is a tropical fruit that belongs to the Anacardiaceae family and is prized for its juiciness, unique flavour, and worldwide popularity. The current study aimed to probe into antidepressant power (ADP) of MIS in animals and confirmation of ADP with in silico induced-fit molecular docking. The depression model was prepared by exposing mice to various stressors from 9:00 am to 2:00 pm during 42 days study period. MIS extract and fluoxetine were given daily for 30 min before exposing animals to stressors. ADP was evaluated by various behavioural tests and biochemical analysis. Results showed increased physical activity in mice under behavioural tests, plasma nitrite and malondialdehyde (MDA) levels and monoamine oxidase A (MAO-A) activity decreased dose-dependently in MIS treated mice and superoxide dismutases (SOD) levels increased in treated groups as compared to disease control. With the peculiar behaviour and significant interactions of the functional residues of target proteins with selected ligands along with the best absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties, it is concluded that catechin could be the best MAO-A inhibitor at a binding energy of -8.85 kcal/mol, and two hydrogen bonds were generated with Cys406 (A) and Gly443 (A) residues of the active binding site of MAO-A enzyme. While catechin at -6.86 kcal/mol generated three hydrogen bonds with Ala263 (A) and Gly434 (A) residues of the active site of monoamine oxidase B (MAO-B) enzyme and stabilized the best conformation. Therefore, it is highly recommended to test the selected lead-like compound catechin in the laboratory with biological system analysis to confirm its activity as MAO-A and MAO-B inhibitors so it can be declared as one of the novel therapeutic options with anti-depressant activity. Our findings concluded that M. indica seeds could be a significant and alternative anti-depressant therapy.
Identifiants
pubmed: 35344129
doi: 10.1007/s11011-022-00955-0
pii: 10.1007/s11011-022-00955-0
doi:
Substances chimiques
Antidepressive Agents
0
Plant Extracts
0
Catechin
8R1V1STN48
Monoamine Oxidase Inhibitors
0
Monoamine Oxidase
EC 1.4.3.4
Phytochemicals
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
483-505Subventions
Organisme : Taif University
ID : TURSP-2020/309
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Bekris S, Antoniou K, Daskas S, Papadopoulou-Daifoti Z (2005) Behavioural and neurochemical effects induced by chronic mild stress applied to two different rat strains. Behav Brain Res 161(1):45–59. https://doi.org/10.1016/j.bbr.2005.01.005
doi: 10.1016/j.bbr.2005.01.005
Berton O, McClung CA, Dileone RJ, Krishnan V, Renthal W, Russo SJ, Graham D, Tsankova NM, Bolanos CA, Rios M, Monteggia LM, Self DW, Nestler EJ (2006) Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 311(5762):864–868. https://doi.org/10.1126/science.1120972
doi: 10.1126/science.1120972
Bilici M, Efe H, Köroğlu MA, Uydu HA, Bekaroğlu M, Değer O (2001) Antioxidative enzymeactivities and lipid peroxidation in major depression: alterations by antidepressant treatments. J Affect Disord 64(1):43–51. https://doi.org/10.1016/s0165-0327(00)00199-3
doi: 10.1016/s0165-0327(00)00199-3
Binda C, Wang J, Pisani L, Caccia C, Carotti A, Salvati P, Edmondson DE, Mattevi A (2007) Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs. J Med Chem 50(23):5848–5852. https://doi.org/10.1021/jm070677y
doi: 10.1021/jm070677y
Capuzzi SJ, Muratov EN, Tropsha A (2017) Phantom PAINS: problems with the utility of alerts for pan-assay interference compoundS. J Chem Inf Model 57(3):417–427. https://doi.org/10.1021/acs.jcim.6b00465
doi: 10.1021/acs.jcim.6b00465
Chhillar R, Dhingra D (2013) Antidepressant-like activity of gallic acid in mice subjected tounpredictable chronic mild stress. Fundam Clin Pharmacol 27(4):409–418. https://doi.org/10.1111/j.1472-8206.2012.01040.x
doi: 10.1111/j.1472-8206.2012.01040.x
Choi GY, Kim HB, Hwang ES, Lee S, Kim MJ, Choi JY, Lee SO, Kim SS, Park JH (2017) Curcumin alters neural plasticity and viability of intact hippocampal circuits and attenuates behavioral despair and COX-2 expression in chronically stressed rats. Mediators Inflamm 2017:6280925. https://doi.org/10.1155/2017/6280925
doi: 10.1155/2017/6280925
Choi YJ, Chong HS, Kim YK, Hwang KH ( 2013) Studies about monoamine oxidase inhibitory activities of Korean Green Tea (Teae sinensis L.) harvested from different time and location. Nat Prod The Korean Society of Pharmacognosy Sci 19(4):281–285
Detanico BC, Piato AL, Freitas JJ, Lhullier FL, Hidalgo MP, Caumo W, Elisabetsky E (2009) Antidepressant-like effects of melatonin in the mouse chronic mild stress model. Eur JPharmacol 607(1–3):121–125. https://doi.org/10.1016/j.ejphar.2009.02.037
doi: 10.1016/j.ejphar.2009.02.037
Dhingra D, Goyal PK (2008) Evidences for the Involvement of Monoaminergic and GABAergic Systems in Antidepressant-like Activity of Tinospora cordifolia in Mice. Indian J Pharm Sci 70(6):761–767. https://doi.org/10.4103/0250-474X.49118
doi: 10.4103/0250-474X.49118
Ducottet C, Belzung C (2004) Behaviour in the elevated plus-maze predicts coping after subchronic mild stress in mice. Physiol Behav 81(3):417–426. https://doi.org/10.1016/j.physbeh.2004.01.013
doi: 10.1016/j.physbeh.2004.01.013
Dulawa SC, Hen R (2005) Recent advances in animal models of chronic antidepressant effects: the novelty-induced hypophagia test. Neurosci Biobehav Rev 29(4–5):771–783. https://doi.org/10.1016/j.neubiorev.2005.03.017
doi: 10.1016/j.neubiorev.2005.03.017
Eloziia N, Kumar N, Kothiyal P, Deka P, Nayak BK (2017) A review on antidepressant plants. J Pharm Res 11(5):382–396. https://doi.org/10.1016/j.jopr.2013.10.003
doi: 10.1016/j.jopr.2013.10.003
Finberg JP, Rabey JM (2016) Inhibitors of MAO-A and MAO-B in Psychiatry and Neurology. Front Pharmacol 18(7):340. https://doi.org/10.3389/fphar.2016.00340
doi: 10.3389/fphar.2016.00340
García D, Leiro J, Delgado R, Sanmartín ML, Ubeira FM (2003) Mangifera indica L. extract (Vimang) and mangiferin modulate mouse humoral immune responses. Phytother Res 17(10):182–187. https://doi.org/10.1002/ptr.1338
Garrido G, González D, Lemus Y, García D, Lodeiro L, Quintero G, Delporte C, Núñez-Sellés AJ, Delgado R (2004) In vivo and in vitro anti-inflammatory activity of Mangifera indica L. extract (VIMANG). Pharmacol Res 50(2):143–149. https://doi.org/10.1016/j.phrs.2003.12.003
Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR (1982) Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Anal Biochem 126(1):131–138
Hou WC, Lin RD, Chen CT, Lee MH (2005) Monoamine oxidase B (MAO-B) inhibition by active principles from Uncaria rhynchophylla. J Ethnopharmacol 100(1–2):216–220. https://doi.org/10.1016/j.jep.2005.03.017
doi: 10.1016/j.jep.2005.03.017
Iijima M, Fukumoto K, Chaki S (2012) Acute and sustained effects of a metabotropic glutamate 5 receptor antagonist in the novelty-suppressed feeding test. Behav Brain Res. 235(2):287–292. https://doi.org/10.1016/j.bbr.2012.08.016
doi: 10.1016/j.bbr.2012.08.016
Iman S, Saleem U, Ahmad B (2020) Pharmacological screening of Mangifera indica seeds for antidepressant-like action along with a mechanistic study. ACS Omega 5(41):26924–26932. https://doi.org/10.1021/acsomega.0c04187
doi: 10.1021/acsomega.0c04187
Jahurul MH, Zaidul IS, Ghafoor K, Al-Juhaimi FY, Nyam KL, Norulaini NA, Sahena F, Mohd Omar AK (2015) Mango (Mangifera indica L.) by-products and their valuable components: a review. Food Chem 183:173–180. https://doi.org/10.1016/j.foodchem.2015.03.046
Jain C, Singh A, Kumar P, Gautam K (2014) Anti-diabetic potential of flavonoids and other crude extracts of stem bark of Mangifera indica Linn: a comparative study. J Sci Innov Res (1):21–27
Joca SR, Guimarães FS (2006) Inhibition of neuronal nitric oxide synthase in the rat hippocampus induces antidepressant-like effects. Psychopharmacology (Berl). 185(3):298–305. https://doi.org/10.1007/s00213-006-0326-2
doi: 10.1007/s00213-006-0326-2
Katon WJ, Young BA, Russo J, Lin EHB, Ciechanowski P, Ludman EJ, Von Korff MR (2013) Association of depression with increased risk of severe hypoglycemic episodes in patients with diabetes. Ann Fam Med 11(3):245–250
Kim KS, Kwon HJ, Baek IS, Han PL (2012) Repeated short-term (2h×14d) emotional stress induces lasting depression-like behavior in mice. Exp Neurobiol 21(1):16–22. https://doi.org/10.5607/en.2012.21.1.16
doi: 10.5607/en.2012.21.1.16
Kioukia-Fougia N, Antoniou K, Bekris S, Liapi C, Christofidis I, Papadopoulou-Daifoti Z (2002) The effects of stress exposure on the hypothalamic-pituitary-adrenal axis, thymus, thyroid hormones and glucose levels. Prog Neuropsychopharmacol Biol Psychiatry 26(5):823–830. https://doi.org/10.1016/s0278-5846(01)00297-4
doi: 10.1016/s0278-5846(01)00297-4
Konkle AT, Baker SL, Kentner AC, Barbagallo LS, Merali Z, Bielajew C (2003) Evaluation of the effects of chronic mild stressors on hedonic and physiological responses: sex and strain compared. Brain Res 992(2):227–238. https://doi.org/10.1016/j.brainres.2003.08.047
doi: 10.1016/j.brainres.2003.08.047
Korczak DJ, Pereira S, Koulajian K, Matejcek A, Giacca A (2011) Type 1 diabetes mellitus and major depressive disorder: evidence for a biological link. Diabetologia 54(10):2483–2493. https://doi.org/10.1007/s00125-011-2240-3
doi: 10.1007/s00125-011-2240-3
Kothari S, Minda M, Tonpay SD (2010) Anxiolytic and antidepressant activities of methanol extract of Aegle marmelos leaves in mice. Indian J Physiol Pharmacol 54(4):318–328
Kumar B, Kuhad A, Chopra K (2011) Neuropsychopharmacological effect of sesamol in unpredictable chronic mild stress model of depression: behavioral and biochemical evidences. Psychopharmacology (Berl) 214(4):819–828. https://doi.org/10.1007/s00213-010-2094-2
doi: 10.1007/s00213-010-2094-2
Kumar GP, Kumar VS, Kumar SA (2016) Pharmacological and phytochemical aspects of lichen Parmelia perlata: A review. International Journal of Research in Ayurveda and Pharmacy 7(1):102–107. https://doi.org/10.7897/2277-4343.13018
doi: 10.7897/2277-4343.13018
Laskowski RA, Swindells MB (2011) LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. J Chem Inf Model 51(10):2778–2786. https://doi.org/10.1021/ci200227u
doi: 10.1021/ci200227u
Lee CY (2013) Chronic restraint stress induces intestinal inflammation and alters the expression of hexose and lipid transporters. Clin Exp Pharmacol Physiol 40(6):385–391. https://doi.org/10.1111/1440-1681.12096
doi: 10.1111/1440-1681.12096
Li Y, Ji YJ, Jiang H, Liu DX, Zhang Q, Fan SJ, Pan F (2009) Effects of unpredictable chronic stress on behavior and brain-derived neurotrophic factor expression in CA3 subfield and dentate gyrus of the hippocampus in different aged rats. Chin Med J (Engl) 122(13):1564–1569
Lila MA, Raskin I (2005) Health-related interactions of phytochemicals. J Food Sci 70(1):R20-7. https://doi.org/10.12691/ajfst-10-1-3
doi: 10.12691/ajfst-10-1-3
Ma J, Yoshimura M, Yamashita E, Nakagawa A, Ito A, Tsukihara T (2004) Structure of rat monoamine oxidase A and its specific recognitions for substrates and inhibitors. J Mol Biol 338(1):103–114. https://doi.org/10.1016/j.jmb.2004.02.032
doi: 10.1016/j.jmb.2004.02.032
Machado-Vieira R, Salvadore G, Luckenbaugh DA, Manji HK, Zarate CA Jr (2008) Rapid onset ofantidepressant action: a new paradigm in the research and treatment of major depressive disorder. J Clin Psychiatry 69(6):946–958. https://doi.org/10.4088/jcp.v69n0610
doi: 10.4088/jcp.v69n0610
Marwat SK, Rehman FU (2011) Medicinal folk recipes used as traditional phytotherapies in district Dera Ismail Khan, KPK, Pakistan. Pak J Bot 43(3):1453–1462. https://doi.org/10.21162/PAKJAS
Mazzio EA, Harris N, Soliman KF (1998) Food constituents attenuate monoamine oxidase activity and peroxide levels in C6 astrocyte cells. Planta Med 64(7):603–606. https://doi.org/10.1055/s-2006-957530
doi: 10.1055/s-2006-957530
Mishra H, Singh N, Lahiri T, Misra K (2009) A comparative study on the molecular descriptors for predicting drug-likeness of small molecules. Bioinformation 3(9):384–388. https://doi.org/10.6026/97320630003384
doi: 10.6026/97320630003384
Mossie A, Kindu D, Negash A (2016) Prevalence and severity of depression and its association with substance use in Jimma Town. Southwest Ethiopia. Depress Res Treat. 2016:3460462. https://doi.org/10.1155/2016/3460462
doi: 10.1155/2016/3460462
Ogu CC, Maxa JL (2000) Drug interactions due to cytochrome P450. Proc (Bayl Univ Med Cent) 13(4):421–423. https://doi.org/10.1080/08998280.2000
doi: 10.1080/08998280.2000
Osman W, Ismail EMOA, Shantier SW, Mohammed MS, Mothana RA, Muddathir A, Khalid HS (2021) In silico assessment of potential leads identified from Bauhinia rufescens Lam. as α-glucosidase and α-amylase inhibitors. J Recept Signal Transduct Res 41(2):159–169. https://doi.org/10.1080/10799893.2020.1800734
Pajouhesh H, Lenz GR (2005) Medicinal chemical properties of successful central nervous system drugs. NeuroRx 2(4):541–553. https://doi.org/10.1602/neurorx.2.4.541
doi: 10.1602/neurorx.2.4.541
Pan Y, Kong L, Xia X, Zhang W, Xia Z, Jiang F (2005) Antidepressant-like effect of icariin and its possible mechanism in mice. Pharmacol Biochem Behav. 82(4):686–694. https://doi.org/10.1016/j.pbb.2005.11.010
doi: 10.1016/j.pbb.2005.11.010
Park MJ, Yoo SW, Choe BS, Dantzer R, Freund GG (2012) Acute hypoglycemia causes depressivelike behaviors in mice. Metabolism 61(2):229–236. https://doi.org/10.1016/j.metabol.2011.06.013
doi: 10.1016/j.metabol.2011.06.013
Piato AL, Detanico BC, Jesus JF, Lhullier FL, Nunes DS, Elisabetsky E (2008) Effects of Marapuama in the chronic mild stress model: further indication of antidepressantproperties. J Ethnopharmacol 118(2):300–304. https://doi.org/10.1016/j.jep.2008.04.018
doi: 10.1016/j.jep.2008.04.018
Ribeiro SMR, Barbosa LCA, Queiroz JH, Knödler M, Schieber A (2008) Phenolic compounds and antioxidant capacity of Brazilian mango (Mangifera indica L.) varieties. Food Chem 110(3):620–626. https://doi.org/10.1016/j.foodchem.2022.132706
Saleem U, Shehzad A, Shah S, Raza Z, Shah MA, Bibi S, Chauhdary Z, Ahmad B (2021) Antiparkinsonian activity of Cucurbita pepo seeds along with possible underlying mechanism. Metab Brain Dis 36(6):1231–1251. https://doi.org/10.1007/s11011-021-00707-6
doi: 10.1007/s11011-021-00707-6
Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, Belzung C, Hen R (2003) Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301(5634):805–809. https://doi.org/10.1126/science.1083328
doi: 10.1126/science.1083328
Sim YB, Park SH, Kang YJ, Kim SS, Kim CH, Kim SJ, Jung JS, Ryu OH, Choi MG, Choi SS, Suh HW (2013) Effect of cholera toxin administered supraspinally or spinally on the blood glucose level in pain and dglucose fed animal models. Korean J Physiol Pharmacol. 17(2):163–167. https://doi.org/10.4196/kjpp.2013.17.2.163
doi: 10.4196/kjpp.2013.17.2.163
Terstappen GC, Reggiani A (2001) In silico research in drug discovery. Trends Pharmacol Sci 22(1):23–26. https://doi.org/10.1016/s0165-6147(00)01584-4
doi: 10.1016/s0165-6147(00)01584-4
Torres-León C, Rojas R, Contreras-Esquivel JC, Serna-Cock L, Belmares-Cerda RE, Aguilar CV (2016) Trends in food science & technology & technology. Mango Seed: Functional and Nutritional Properties 55:109–117. https://doi.org/10.1016/j.foodres.2021.110520
doi: 10.1016/j.foodres.2021.110520
Tsoi B, He RR, Yang DH, Li YF, Li XD, Li WX, Abe K, Kurihara H (2011) Carnosineameliorates stress-induced glucose metabolism disorder in restrained mice. J Pharmacol Sci 117(4):223–229. https://doi.org/10.1254/jphs.11131fp
doi: 10.1254/jphs.11131fp
Vaváková M, Ďuračková Z, Trebatická J (2015) Markers of oxidative stress and neuroprogression in depression disorder. Oxid Med Cell Longev 2015:898393. https://doi.org/10.1155/2015/898393
Wang J, Chai A, Zhou Q, Lv L, Wang L, Yang Y, Xu L (2013) Chronic clomipramine treatment reverses core symptom of depression in subordinate tree shrews. PLoS One 8(12):e80980. https://doi.org/10.1371/journal.pone.0080980
Willner P (2005) Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology 52(2):90–110. https://doi.org/10.1159/000087097
doi: 10.1159/000087097
World Health Organization (2012) Mental health: Disorders management. Retrieved from https://www.who.int/mental_health/management/en/
Yalcin I, Aksu F, Belzung C (2005) Effects of desipramine and tramadol in a chronic mild stress model in mice are altered by yohimbine but not by pindolol. Eur J Pharmacol 514(2–3):165–174. https://doi.org/10.1016/j.ejphar.2022.174890
doi: 10.1016/j.ejphar.2022.174890
Yang ZJ, He JH, Lu AP, Liu S, Hou TJ, Cao DS (2021) Benchmarking the mechanisms of frequent hitters: limitation of PAINS alerts. Drug Discov Today 26(6):1353–1358. https://doi.org/10.1016/j.drudis.2021.02.003
Zarate C Jr, Machado-Vieira R, Henter I, Ibrahim L, Diazgranados N, Salvadore G (2010) Glutamatergic modulators: the future of treating mood disorders? Harv Rev Psychiatry 18(5):293–303. https://doi.org/10.3109/10673229.2010.511059