Allergen immunotherapy in MASK-air users in real-life: Results of a Bayesian mixed-effects model.

allergic rhinitis immunotherapy mobile health patient-reported outcomes real-life data analysis

Journal

Clinical and translational allergy
ISSN: 2045-7022
Titre abrégé: Clin Transl Allergy
Pays: England
ID NLM: 101576043

Informations de publication

Date de publication:
Mar 2022
Historique:
revised: 17 01 2022
received: 08 10 2021
accepted: 31 01 2022
entrez: 28 3 2022
pubmed: 29 3 2022
medline: 29 3 2022
Statut: ppublish

Résumé

Evidence regarding the effectiveness of allergen immunotherapy (AIT) on allergic rhinitis has been provided mostly by randomised controlled trials, with little data from real-life studies. To compare the reported control of allergic rhinitis symptoms in three groups of users of the MASK-air We assessed the MASK-air We analysed a total of 42,756 days from 1,093 grass allergy patients, including 18,479 days of users under AIT. Compared to no AIT, SCIT was associated with similar VAS levels and CSMS. Compared to no AIT, SLIT-tablet was associated with lower values of VAS global allergy symptoms (average difference = 7.5 units out of 100; 95% credible interval [95%CrI] = -12.1;-2.8), lower VAS Work (average difference = 5.0; 95%CrI = -8.5;-1.5), and a lower CSMS (average difference = 3.7; 95%CrI = -9.3;2.2). When compared to SCIT, SLIT-tablet was associated with lower VAS global allergy symptoms (average difference = 10.2; 95%CrI = -17.2;-2.8), lower VAS Work (average difference = 7.8; 95%CrI = -15.1;0.2), and a lower CSMS (average difference = 9.3; 95%CrI = -18.5;0.2). In patients with grass pollen allergy, SLIT-tablet, when compared to no AIT and to SCIT, is associated with lower reported symptom severity. Future longitudinal studies following internationally-harmonised standards for performing and reporting real-world data in AIT are needed to better understand its 'real-world' effectiveness.

Sections du résumé

BACKGROUND BACKGROUND
Evidence regarding the effectiveness of allergen immunotherapy (AIT) on allergic rhinitis has been provided mostly by randomised controlled trials, with little data from real-life studies.
OBJECTIVE OBJECTIVE
To compare the reported control of allergic rhinitis symptoms in three groups of users of the MASK-air
METHODS METHODS
We assessed the MASK-air
RESULTS RESULTS
We analysed a total of 42,756 days from 1,093 grass allergy patients, including 18,479 days of users under AIT. Compared to no AIT, SCIT was associated with similar VAS levels and CSMS. Compared to no AIT, SLIT-tablet was associated with lower values of VAS global allergy symptoms (average difference = 7.5 units out of 100; 95% credible interval [95%CrI] = -12.1;-2.8), lower VAS Work (average difference = 5.0; 95%CrI = -8.5;-1.5), and a lower CSMS (average difference = 3.7; 95%CrI = -9.3;2.2). When compared to SCIT, SLIT-tablet was associated with lower VAS global allergy symptoms (average difference = 10.2; 95%CrI = -17.2;-2.8), lower VAS Work (average difference = 7.8; 95%CrI = -15.1;0.2), and a lower CSMS (average difference = 9.3; 95%CrI = -18.5;0.2).
CONCLUSION CONCLUSIONS
In patients with grass pollen allergy, SLIT-tablet, when compared to no AIT and to SCIT, is associated with lower reported symptom severity. Future longitudinal studies following internationally-harmonised standards for performing and reporting real-world data in AIT are needed to better understand its 'real-world' effectiveness.

Identifiants

DOI: 10.1002/clt2.12128 PMID: 35344295 PMC: PMC8967259
pubmed: 35344295
doi: 10.1002/clt2.12128
pmc: PMC8967259
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e12128

Subventions

Organisme : EIT Health Twinning
Organisme : Mylan-Viatris
Organisme : GSK
Organisme : ALK
Organisme : Uriach
Organisme : Novartis
Organisme : Charité Universitätsmedizin Berlin
Organisme : EIT Health POLLAR

Informations de copyright

© 2022 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.

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Auteurs

Bernardo Sousa-Pinto (B)

MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
CINTESIS-Center for Health Technology and Services Research, University of Porto, Porto, Portugal.
ORCID: 0000-0002-1277-3401

Luís Filipe Azevedo (LF)

MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
CINTESIS-Center for Health Technology and Services Research, University of Porto, Porto, Portugal.

Ana Sá-Sousa (A)

MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
CINTESIS-Center for Health Technology and Services Research, University of Porto, Porto, Portugal.

Rafael José Vieira (RJ)

MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
CINTESIS-Center for Health Technology and Services Research, University of Porto, Porto, Portugal.

Rita Amaral (R)

MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
CINTESIS-Center for Health Technology and Services Research, University of Porto, Porto, Portugal.

Ludger Klimek (L)

Department of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany.
Center for Rhinology and Allergology, Wiesbaden, Germany.

Wienczyslawa Czarlewski (W)

Medical Consulting Czarlewski, Levallois, France.
MASK-air, Montpellier, France.

Josep M Anto (JM)

ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
Universitat Pompeu Fabra (UPF), Barcelona, Spain.
CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.

Anna Bedbrook (A)

MASK-air, Montpellier, France.

Violeta Kvedariene (V)

Institute of Biomedical Sciences, Department of Pathology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Institute of Clinical Medicine, Clinic of Chest Diseases and Allergology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.

Maria Teresa Ventura (MT)

University of Bari Medical School, Unit of Geriatric Immunoallergology, Bari, Italy.

Ignacio J Ansotegui (IJ)

Department of Allergy and Immunology, Hospital Quirónsalud Bizkaia, Bilbao, Spain.

Karl-Christian Bergmann (KC)

Institute of Allergology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Corporate Member of Freie Universität Berlin, Berlin, Germany.
Humboldt-Universität zu Berlin, Berlin, Germany.
ORCID: 0000-0002-0306-9922

Luisa Brussino (L)

Department of Medical Sciences, Allergy and Clinical Immunology Unit, University of Torino & Mauriziano Hospital, Torino, Italy.

G Walter Canonica (GW)

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center IRCCS, Rozzano, Italy.

Victoria Cardona (V)

Allergy Section, Department of Internal Medicine, Hospital Vall d'Hebron & ARADyAL Research Network, Barcelona, Spain.
ORCID: 0000-0003-2197-9767

Pedro Carreiro-Martins (P)

Serviço de Imunoalergologia, Hospital de Dona Estefânia, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal.
NOVA Medical School/Comprehensive Health Research Centre (CHRC), Lisbon, Portugal.

Thomas Casale (T)

Division of Allergy/immunology, University of South Florida, Tampa, Florida, USA.

Lorenzo Cecchi (L)

SOS Allergology and Clinical Immunology, USL Toscana Centro, Prato, Italy.

Tomás Chivato (T)

School of Medicine, University CEU San Pablo, Madrid, Spain.

Derek K Chu (DK)

Department of Medicine and Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario, Canada.

Cemal Cingi (C)

Eskisehir Osmangazi University, Medical Faculty, ENT Department, Eskisehir, Turkey.

Elisio M Costa (EM)

UCIBIO, REQUINTE, Faculty of Pharmacy and Competence Center on Active and Healthy Ageing of University of Porto (Porto4Ageing), Porto, Portugal.

Alvaro A Cruz (AA)

Fundaçao ProAR, Federal University of Bahia, Salvador, Bahia, Brazil.
GARD/WHO Planning Group, Salvador, Bahia, Brazil.

Giulia De Feo (G)

Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Salerno, Italy.

Philippe Devillier (P)

VIM Suresnes, UMR_0892, Pôle des Maladies des Voies Respiratoires, Hôpital Foch, Université Paris-Saclay, Suresnes, France.

Wytske J Fokkens (WJ)

Department of Otorhinolaryngology, Amsterdam University Medical Centres, location AMC, Amsterdam, The Netherlands.

Mina Gaga (M)

ERS President 2017-2018, Athens Chest Hospital, 7th Respiratory Medicine Department and Asthma Center, Athens, Greece.

Bilun Gemicioğlu (B)

Department of Pulmonary Diseases, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Turkey.

Tari Haahtela (T)

Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

Juan Carlos Ivancevich (JC)

Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina.

Zhanat Ispayeva (Z)

Department of Allergology and Clinical Immunology of the Kazakh National Medical University, Almaty, Kazakhstan.

Marek Jutel (M)

Department of Clinical Immunology, Wrocław Medical University, Wroclaw, Poland.
ALL-MED Medical Research Institute, Wroclaw, Poland.

Piotr Kuna (P)

Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland.

Igor Kaidashev (I)

Poltava State Medical University, Poltava, Ukraine.

Helga Kraxner (H)

Department of Otorhinolaryngology, Head and Neck Surgery, Semmelweis University, Budapest, Hungary.

Désirée E Larenas-Linnemann (DE)

Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico.

Daniel Laune (D)

KYomed INNOV, Montpellier, France.

Brian Lipworth (B)

Scottish Centre for Respiratory Research, Cardiovascular & Diabetes Medicine, Medical Research Institute, Ninewells Hospital, University of Dundee, Dundee, UK.

Renaud Louis (R)

Department of Pulmonary Medicine, CHU Sart-Tilman, Liege, Belgium.
GIGA I3 Research Group, Liege, Belgium.

Michaël Makris (M)

Allergy Unit 'D Kalogeromitros', 2nd Department of Dermatology and Venereology, National & Kapodistrian University of Athens, 'Attikon' University Hospital, Chaidari, Greece.

Riccardo Monti (R)

Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico Universitario A Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

Mario Morais-Almeida (M)

Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal.

Ralph Mösges (R)

ClinCompetence Cologne GmbH, Cologne, Germany.
IMSB, Medical Faculty, University of Cologne, Cologne, Germany.
ORCID: 0000-0002-1928-810X

Joaquim Mullol (J)

Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, Barcelona, Spain.
Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, University of Barcelona, Barcelona, Spain.

Mikaëla Odemyr (M)

EFA European Federation of Allergy and Airways Diseases Patients' Associations, Brussels, Belgium.

Yoshitaka Okamoto (Y)

Department of Otorhinolaryngology, Chiba University Hospital, Chiba, Japan.

Nikolaos G Papadopoulos (NG)

Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece.

Vincenzo Patella (V)

Division of Allergy and Clinical Immunology, Department of Medicine, Agency of Health ASL Salerno, 'Santa Maria della Speranza' Hospital, Salerno, Italy.

Nhân Pham-Thi (N)

Ecole Polytechnique Palaiseau, IRBA (Institut de Recherche bio-Médicale des Armées), Bretigny, France.

Frederico S Regateiro (FS)

MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
CINTESIS-Center for Health Technology and Services Research, University of Porto, Porto, Portugal.

Sietze Reitsma (S)

Department of Otorhinolaryngology, Amsterdam University Medical Centres, location AMC, Amsterdam, The Netherlands.

Philip W Rouadi (PW)

Department of Otolaryngology-Head and Neck Surgery, Eye and Ear University Hospital, Beirut, Lebanon.
ENT Department, Dar Al Shifa Hospital, Salmiya, Kuwait.

Boleslaw Samolinski (B)

Department of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Warsaw, Poland.

Milan Sova (M)

Department of Pulmonary Medicine and Tuberculosis, University Hospital Brno, Liskovec, Czech Republic.

Ana Todo-Bom (A)

MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.

Luis Taborda-Barata (L)

Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal.
UBIAir-Clinical & Experimental Lung Centre, University of Beira Interior, Covilhã, Portugal.
Department of Immunoallergology, Cova da Beira University Hospital Centre, Covilhã, Portugal.

Peter Valentin Tomazic (PV)

Department of General ORL, H&NS, Medical University of Graz, ENT-University Hospital Graz, Graz, Austria.

Sanna Toppila-Salmi (S)

Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

Joaquin Sastre (J)

Fundacion Jimenez Diaz, CIBERES, Faculty of Medicine, Autonoma University of Madrid, Madrid, Spain.

Ioanna Tsiligianni (I)

Health Planning Unit, Department of Social Medicine, Faculty of Medicine, University of Crete, Rethymno, Greece.
International Primary Care Respiratory Group IPCRG, Aberdeen, Scotland.

Arunas Valiulis (A)

Institute of Clinical Medicine and Institute of Health Sciences, Medical Faculty of Vilnius University, Vilnius, Lithuania.

Dana Wallace (D)

Nova Southeastern University, Fort Lauderdale, Florida, USA.

Susan Waserman (S)

Department of Medicine, Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada.

Arzu Yorgancioglu (A)

Department of Pulmonology, Celal Bayar University, Manisa, Turkey.

Mihaela Zidarn (M)

University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia.
University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia.
ORCID: 0000-0003-0515-5207

Torsten Zuberbier (T)

Institute of Allergology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Corporate Member of Freie Universität Berlin, Berlin, Germany.
Humboldt-Universität zu Berlin, Berlin, Germany.
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany.

João Almeida Fonseca (JA)

MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
CINTESIS-Center for Health Technology and Services Research, University of Porto, Porto, Portugal.
Medicina, EDucação, I&D e Avaliação, Lda (MEDIDA), Porto, Portugal.

Jean Bousquet (J)

Institute of Allergology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Corporate Member of Freie Universität Berlin, Berlin, Germany.
Humboldt-Universität zu Berlin, Berlin, Germany.
University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia.
University Hospital Montpellier, Montpellier, France.
ORCID: 0000-0002-4061-4766

Oliver Pfaar (O)

Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
ORCID: 0000-0003-4374-9639

Classifications MeSH