AllergoOncology: Role of immune cells and immune proteins.
IgE
allergy
immune surveillance
immunomodulation
malignancy susceptibility
Journal
Clinical and translational allergy
ISSN: 2045-7022
Titre abrégé: Clin Transl Allergy
Pays: England
ID NLM: 101576043
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
revised:
21
12
2021
received:
28
08
2021
accepted:
18
02
2022
entrez:
28
3
2022
pubmed:
29
3
2022
medline:
29
3
2022
Statut:
ppublish
Résumé
Immune cells and immune proteins play a pivotal role in host responses to pathogens, allergens and cancer. Understanding the crosstalk between allergic response and cancer, immune surveillance, immunomodulation, role of immunoglobulin E (IgE)-mediated functions and help to develop novel therapeutic strategies. Allergy and oncology show two opposite scenarios: whereas immune tolerance is desired in allergy, it is detrimental in cancer. The current review provides an update on the role of immune cells and immune proteins in allergy and cancer fields. Authors investigated the role of relevant immunological markers and the correlation with cancer progression or cancer suppression. Activated immune cells such as macrophages 'M1', dendritic cells (DCs), innate lymphoid cells (ILC2), NK cells, Th1, follicular T helper cells (TFH), TCD8+, B lymphocytes and eosinophils have inhibitory effects on tumourigenesis, while tolerogenic cells such as macrophages 'M2,' tolerogenic DCs, ILC3, T and B regulatory lymphocytes appear to favour carcinogenesis. Mastocytes and alarmins can have both effects. RIgE antibodies and CCCL5 chemokine have an anticancer role, whereas IgG4, free light chains, Il-10, TGF-β, lipocalin-2, CCL1 chemokine promote cancer progression. Fundamental is also the contribution of epigenetic changes regulated by the microRNA in cancer progression. This knowledge represents the key to developing new anticancer therapies.
Sections du résumé
BACKGROUND
BACKGROUND
Immune cells and immune proteins play a pivotal role in host responses to pathogens, allergens and cancer. Understanding the crosstalk between allergic response and cancer, immune surveillance, immunomodulation, role of immunoglobulin E (IgE)-mediated functions and help to develop novel therapeutic strategies. Allergy and oncology show two opposite scenarios: whereas immune tolerance is desired in allergy, it is detrimental in cancer.
AIM
OBJECTIVE
The current review provides an update on the role of immune cells and immune proteins in allergy and cancer fields.
METHODS
METHODS
Authors investigated the role of relevant immunological markers and the correlation with cancer progression or cancer suppression.
RESULTS
RESULTS
Activated immune cells such as macrophages 'M1', dendritic cells (DCs), innate lymphoid cells (ILC2), NK cells, Th1, follicular T helper cells (TFH), TCD8+, B lymphocytes and eosinophils have inhibitory effects on tumourigenesis, while tolerogenic cells such as macrophages 'M2,' tolerogenic DCs, ILC3, T and B regulatory lymphocytes appear to favour carcinogenesis. Mastocytes and alarmins can have both effects. RIgE antibodies and CCCL5 chemokine have an anticancer role, whereas IgG4, free light chains, Il-10, TGF-β, lipocalin-2, CCL1 chemokine promote cancer progression. Fundamental is also the contribution of epigenetic changes regulated by the microRNA in cancer progression.
CONCLUSION
CONCLUSIONS
This knowledge represents the key to developing new anticancer therapies.
Identifiants
pubmed: 35344301
doi: 10.1002/clt2.12133
pmc: PMC8967267
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e12133Informations de copyright
© 2022 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.
Références
Oncotarget. 2017 Feb 21;8(8):13703-13715
pubmed: 28099147
Cancer Epidemiol Biomarkers Prev. 2009 Oct;18(10):2650-4
pubmed: 19755650
Allergy. 2017 Jun;72(6):866-887
pubmed: 28032353
Oncoimmunology. 2021 Feb 8;10(1):1880687
pubmed: 33628623
Cerebrovasc Dis. 2009;27(3):295-302
pubmed: 19202335
Mol Med. 2008 Jul-Aug;14(7-8):476-84
pubmed: 18431461
Biochem Biophys Res Commun. 2003 Jul 25;307(2):375-81
pubmed: 12859967
Am J Epidemiol. 2010 Nov 1;172(9):1015-27
pubmed: 20807738
Oncoimmunology. 2017 Nov 13;7(2):e1393134
pubmed: 29308325
J Asthma. 2015;52(6):545-53
pubmed: 25405361
Cancer Epidemiol Biomarkers Prev. 2013 Apr;22(4):661-9
pubmed: 23513040
Nat Rev Cancer. 2015 Feb;15(2):96-109
pubmed: 25614008
Cell. 2002 May 3;109(3):383-96
pubmed: 12015987
Lancet Oncol. 2014 May;15(6):656-66
pubmed: 24746841
Immunity. 2015 Jul 21;43(1):29-40
pubmed: 26200011
J Immunol. 2005 Jun 15;174(12):7506-15
pubmed: 15944249
Mol Cell. 2011 Oct 21;44(2):265-78
pubmed: 22017873
J Allergy Clin Immunol. 2017 Oct;140(4):982-984
pubmed: 28526623
BMC Public Health. 2004 Nov 04;4:51
pubmed: 15527506
Am J Respir Crit Care Med. 2012 Nov 15;186(10):965-74
pubmed: 22955319
FASEB J. 2003 Feb;17(2):203-13
pubmed: 12554699
Immunotherapy. 2019 Oct;11(14):1231-1251
pubmed: 31422725
Curr Opin Immunol. 2014 Dec;31:31-7
pubmed: 25278425
Cell Mol Life Sci. 2014 May;71(9):1551-79
pubmed: 23811936
Oncogene. 2008 Oct 6;27(45):5959-74
pubmed: 18836476
J Immunol. 2009 Oct 1;183(7):4705-14
pubmed: 19752225
Int J Mol Sci. 2018 Sep 09;19(9):
pubmed: 30205617
Leuk Res. 2014 Oct;38(10):1137-44
pubmed: 25171954
J Leukoc Biol. 2007 Jan;81(1):84-91
pubmed: 17035340
N Engl J Med. 2010 Aug 19;363(8):711-23
pubmed: 20525992
Nat Commun. 2016 Oct 10;7:13045
pubmed: 27721471
Oncoimmunology. 2021 Feb 10;10(1):1883890
pubmed: 33628625
Antioxid Redox Signal. 2011 Apr 1;14(7):1315-35
pubmed: 20969478
Oncotarget. 2016 Mar 29;7(13):16840-54
pubmed: 26919238
PLoS One. 2013 Dec 16;8(12):e81774
pubmed: 24358127
Epidemiology. 2007 Jan;18(1):158-61
pubmed: 17099322
Cancer Res. 2017 Mar 1;77(5):1127-1141
pubmed: 28096174
Nat Immunol. 2015 Jun;16(6):609-17
pubmed: 25915731
F1000Prime Rep. 2014 Mar 03;6:13
pubmed: 24669294
Expert Opin Biol Ther. 2009 Apr;9(4):493-506
pubmed: 19344285
Front Immunol. 2017 Jan 09;7:682
pubmed: 28119694
Tumour Biol. 2017 Jun;39(6):1010428317705747
pubmed: 28631561
Annu Rev Med. 2018 Jan 29;69:349-364
pubmed: 29106804
Oncoimmunology. 2017 Apr 20;6(6):e1317420
pubmed: 28680750
Leukemia. 2003 Sep;17(9):1905-7
pubmed: 12970794
J Allergy Clin Immunol. 2018 Feb;141(2):505-517
pubmed: 29045815
J Biol Regul Homeost Agents. 2020 Mar-Apr;34(2):319-326
pubmed: 32431140
J Allergy Clin Immunol. 2020 May;145(5):1469-1473.e4
pubmed: 31874183
Allergy. 2016 Feb;71(2):267-71
pubmed: 26414117
Cancer Res. 2007 Mar 1;67(5):2382-8
pubmed: 17332371
Front Immunol. 2020 Nov 30;11:571593
pubmed: 33329534
Tumori. 1990 Oct 31;76(5):413-9
pubmed: 2256184
Allergy. 2018 Feb;73(2):328-340
pubmed: 28921585
J Cell Biol. 2019 Mar 4;218(3):740-741
pubmed: 30760493
Nature. 2000 May 18;405(6784):354-60
pubmed: 10830965
J Intern Med. 2003 Oct;254(4):375-85
pubmed: 12974876
J Clin Invest. 2013 Jul;123(7):2873-92
pubmed: 23778140
Immunol Rev. 2007 Dec;220:47-59
pubmed: 17979839
Immunity. 2016 Apr 19;44(4):821-32
pubmed: 26850657
Clin Cancer Res. 2007 May 15;13(10):2836-48
pubmed: 17504981
Oncoimmunology. 2012 Oct 1;1(7):1186-1188
pubmed: 23170274
Biochem Biophys Res Commun. 1965 Jun 9;19(6):739-44
pubmed: 4953930
Clin Transl Allergy. 2022 Mar;12(3):e12133
pubmed: 35344301
Clin Exp Allergy. 2000 Dec;30(12):1717-23
pubmed: 11122209
Front Immunol. 2013 Aug 07;4:232
pubmed: 23966994
Int Immunopharmacol. 2018 Apr;57:139-146
pubmed: 29482158
Cancer Immunol Immunother. 2012 Dec;61(12):2295-309
pubmed: 22692757
J Immunol. 2009 Oct 1;183(7):4530-6
pubmed: 19748979
Cancer Res. 2006 Aug 1;66(15):7741-7
pubmed: 16885377
Science. 2010 Feb 5;327(5966):656-61
pubmed: 20133564
Am J Hematol. 2013 Dec;88(12):1050-4
pubmed: 23918679
Immunity. 2017 Jan 17;46(1):10-13
pubmed: 28099859
Eur J Cancer. 2006 Nov;42(17):3028-33
pubmed: 16945522
Clin Rev Allergy Immunol. 2016 Dec;51(3):338-352
pubmed: 27277132
J Immunol. 2008 Feb 15;180(4):2270-5
pubmed: 18250435
Nat Immunol. 2010 Nov;11(11):1057-62
pubmed: 20935646
N Engl J Med. 1981 Jan 15;304(3):135-40
pubmed: 6255329
Prostate. 2013 Mar;73(4):346-54
pubmed: 22887127
Blood. 2003 Apr 1;101(7):2652-60
pubmed: 12456506
Nat Rev Immunol. 2005 Apr;5(4):331-42
pubmed: 15803152
Cell. 2008 May 30;133(5):775-87
pubmed: 18510923
Int J Cancer. 2011 Nov 1;129(9):2236-47
pubmed: 21170962
Cancer Epidemiol Biomarkers Prev. 2014 Sep;23(9):1903-12
pubmed: 24962839
Cancers (Basel). 2020 Nov 15;12(11):
pubmed: 33203088
J Cancer. 2012;3:432-48
pubmed: 23074383
Allergy. 2015 Feb;70(2):212-9
pubmed: 25443138
J Biol Chem. 1992 Jul 25;267(21):14998-5004
pubmed: 1378843
J Biol Regul Homeost Agents. 2017 Apr-Jun;31(2):263-267
pubmed: 28685525
J Thorac Dis. 2015 Oct;7(10):1732-41
pubmed: 26623095
Eur J Biochem. 1973 Sep 21;38(1):14-9
pubmed: 4774120
J Allergy Clin Immunol. 2013 Sep;132(3):527-535
pubmed: 23993354
Sci Rep. 2016 Jul 14;6:29736
pubmed: 27411958
BMJ. 1989 Nov 18;299(6710):1259-60
pubmed: 2513902
J Exp Clin Cancer Res. 2016 Jun 27;35:103
pubmed: 27349385
Science. 2004 Jan 2;303(5654):83-6
pubmed: 14657504
Nat Immunol. 2014 Dec;15(12):1162-70
pubmed: 25362490
Oxid Med Cell Longev. 2020 Apr 28;2020:2415324
pubmed: 32411322
Biochim Biophys Acta. 2009 Jun;1793(6):993-1007
pubmed: 19121341
Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3068-73
pubmed: 24469805
Br J Cancer. 2013 Feb 5;108(2):361-9
pubmed: 23329235
Gynecol Oncol. 2008 Jul;110(1):13-21
pubmed: 18589210
Curr Mol Med. 2007 Dec;7(8):777-89
pubmed: 18331236
J Allergy Clin Immunol. 2010 Jan;125(1):139-45.e1-3
pubmed: 19818484
Int J Mol Sci. 2020 May 20;21(10):
pubmed: 32443845
Nature. 1974 Oct 11;251(5475):550-1
pubmed: 4547522
Front Biosci (Elite Ed). 2012 Jan 01;4(2):734-45
pubmed: 22201909
Semin Immunol. 2019 Aug;44:101326
pubmed: 31711770
Int J Cancer. 2012 May 15;130(10):2300-9
pubmed: 20017139
Antioxid Redox Signal. 2008 Apr;10(4):785-97
pubmed: 18177234
Front Immunol. 2017 Apr 12;8:424
pubmed: 28446910
Nat Immunol. 2005 Mar;6(3):280-6
pubmed: 15685176
J Exp Med. 2017 Aug 7;214(8):2331-2347
pubmed: 28698286
Mol Ther. 2011 Jun;19(6):1116-22
pubmed: 21427705
Front Immunol. 2018 Nov 13;9:2601
pubmed: 30483263
J Immunol. 2007 Jan 1;178(1):179-85
pubmed: 17182553
Semin Immunol. 2018 Aug;38:1-2
pubmed: 30554607
Nat Rev Immunol. 2010 Dec;10(12):826-37
pubmed: 21088683
Clin Transl Allergy. 2020 Jul 17;10:32
pubmed: 32695309
Scand J Immunol. 2017 Oct;86(4):248
pubmed: 28810080
Invest Ophthalmol Vis Sci. 2007 Mar;48(3):1355-61
pubmed: 17325184
Int J Cancer. 2015 Aug 15;137(4):949-58
pubmed: 25648070
Immunology. 2004 Jul;112(3):352-63
pubmed: 15196202
Oncoimmunology. 2016 Mar 28;5(6):e1154250
pubmed: 27471625
Nat Immunol. 2012 Sep;13(9):832-42
pubmed: 22842346
PLoS One. 2012;7(9):e45466
pubmed: 23029029
Clin Cancer Res. 2013 Aug 1;19(15):4046-57
pubmed: 23723299
Clin Lymphoma Myeloma Leuk. 2021 Apr;21(4):279-288.e7
pubmed: 33342729
Allergy. 2019 Mar;74(3):483-494
pubmed: 30338531
J Clin Invest. 2012 Mar;122(3):787-95
pubmed: 22378047
Int Immunopharmacol. 2016 Dec;41:1-7
pubmed: 27788370
Microsc Res Tech. 2003 Apr 15;60(6):540-51
pubmed: 12645002
Leuk Res. 2007 Oct;31(10):1365-72
pubmed: 17481729
Nat Rev Cancer. 2015 Jun;15(6):321-33
pubmed: 25998712
J Mol Med (Berl). 2016 May;94(5):535-43
pubmed: 26922618
Semin Immunol. 2013 Dec 15;25(6):430-8
pubmed: 24183701
Cancers (Basel). 2020 Jul 24;12(8):
pubmed: 32722137
Nat Immunol. 2011 Mar;12(3):239-46
pubmed: 21278735
World Allergy Organ J. 2018 Oct 01;11(1):21
pubmed: 30323863
Cancer Res. 2014 Apr 1;74(7):2094-105
pubmed: 24477595
Cancer Lett. 2018 Jul 1;425:116-124
pubmed: 29604393
J Natl Cancer Inst. 2007 Jan 17;99(2):158-66
pubmed: 17227999
Biochim Biophys Acta. 2015 Dec;1852(12):2706-11
pubmed: 26435083
Expert Opin Biol Ther. 2011 Jul;11(7):833-41
pubmed: 21426239
Cancer Epidemiol Biomarkers Prev. 2011 Sep;20(9):1861-4
pubmed: 21742945
Cancer Epidemiol Biomarkers Prev. 2007 Jul;16(7):1492-8
pubmed: 17627016
PLoS One. 2013;8(3):e59397
pubmed: 23533623
J Allergy Clin Immunol. 2009 May;123(5):1142-9, 1149.e1-5
pubmed: 19275959
Blood. 2008 Apr 1;111(7):3388-94
pubmed: 18239085
J Clin Oncol. 2011 Feb 1;29(4):378-85
pubmed: 21172877
Cell Mol Immunol. 2017 Jan;14(1):43-64
pubmed: 27569562
Clin Cancer Res. 2012 Dec 15;18(24):6580-7
pubmed: 23087408
Cancers (Basel). 2021 Mar 25;13(7):
pubmed: 33805904
J Exp Med. 2016 Feb 8;213(2):235-49
pubmed: 26834155
Cancer Res. 2016 Feb 1;76(3):513-6
pubmed: 26772756
Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18704-9
pubmed: 19843690
Allergy. 2008 Oct;63(10):1255-66
pubmed: 18671772
J Natl Cancer Inst. 2010 Apr 21;102(8):557-67
pubmed: 20181958
Curr Opin Immunol. 2018 Aug;53:152-160
pubmed: 29778674
Cancer Lett. 2015 Aug 28;365(1):11-22
pubmed: 25963887
Am J Epidemiol. 2010 Apr 1;171(7):749-64
pubmed: 20228139
Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1478-83
pubmed: 23766387
Cell Death Differ. 2010 Apr;17(4):666-76
pubmed: 19834494
J Hematol Oncol. 2020 Aug 24;13(1):116
pubmed: 32831115
Lancet Oncol. 2015 Mar;16(3):257-65
pubmed: 25704439
BMC Pulm Med. 2011 May 23;11:29
pubmed: 21605405
Int J Mol Sci. 2019 Sep 06;20(18):
pubmed: 31500217
Scand J Immunol. 2017 Aug;86(2):107-112
pubmed: 28513867
Allergy. 2021 May;76(5):1350-1366
pubmed: 32976640
Oncogene. 2017 Feb 2;36(5):639-651
pubmed: 27345402
Cell. 2018 Feb 22;172(5):1022-1037.e14
pubmed: 29429633
Allergy. 2005 Sep;60(9):1116-20
pubmed: 16076294
Cancer Res. 2012 Jul 1;72(13):3290-301
pubmed: 22552293
Science. 2019 Aug 30;365(6456):
pubmed: 31371561