Advanced glycation end-products and advanced oxidation protein products in schizophrenia.

Advanced Oxidation Protein Products Biomarkers Glycation End Products, Advanced / metabolism Humans Oxidative Stress Schizophrenia
Antioxidants Oxidative stress Schizophrenia

Journal

Psychiatry research
ISSN: 1872-7123
Titre abrégé: Psychiatry Res
Pays: Ireland
ID NLM: 7911385

Informations de publication

Date de publication:
05 2022
Historique:
received: 29 07 2021
revised: 21 02 2022
accepted: 20 03 2022
pubmed: 29 3 2022
medline: 20 4 2022
entrez: 28 3 2022
Statut: ppublish

Résumé

Schizophrenia pathophysiology is still not well understood. Genetic factors involving biochemical systems are key players and oxidative stress takes part to the development and worsening of SZ. Oxidative stress led to the permanent production of oxidation products such as advanced glycation end products (AGEs) and advanced oxidation protein products (AOPPs). These proteins interact with their receptor amplifying ROS production and pro-inflammatory cytokines sustaining a permanent loop. We tested plasma levels of AGEs and AOPPs in 30 SZ patients. Their levels were statistically higher than controls confirming their involvement in mental disorders. Antioxidant nutraceuticals and a healthy lifestyle could diminish oxidative stress and ameliorate SZ symptoms.

Identifiants

DOI: 10.1016/j.psychres.2022.114527 PMID: 35344686
pubmed: 35344686
pii: S0165-1781(22)00141-X
doi: 10.1016/j.psychres.2022.114527
pii:
doi:

Substances chimiques

Advanced Oxidation Protein Products 0
Biomarkers 0
Glycation End Products, Advanced 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

114527

Informations de copyright

Copyright © 2022. Published by Elsevier B.V.

Auteurs

Gianluca Pandolfo (G)

Department of Biomedical and Dental Sciences, Morphological and Functional Images, University of Messina, 98125 Messina, Italy. Electronic address: gianluca.pandolfo@unime.it.

Giovanni Genovese (G)

Department of Biomedical and Dental Sciences, Morphological and Functional Images, University of Messina, 98125 Messina, Italy. Electronic address: giovannigeno@live.it.

Antonio Bruno (A)

Department of Biomedical and Dental Sciences, Morphological and Functional Images, University of Messina, 98125 Messina, Italy. Electronic address: antonio.bruno@unime.it.

Domenica Campolo (D)

Department of Biomedical and Dental Sciences, Morphological and Functional Images, University of Messina, 98125 Messina, Italy. Electronic address: domenica.campolo@unime.it.

Valeria Tigano (V)

School and Operative Unit of Allergy and Clinical Immunology, Policlinico "G. Martino", Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy. Electronic address: valeria.tigano@unime.it.

Mariateresa Cristani (M)

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy. Electronic address: mariateresa.cristani@unime.it.

Marco Casciaro (M)

School and Operative Unit of Allergy and Clinical Immunology, Policlinico "G. Martino", Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy. Electronic address: mcasciaro@unime.it.

Giovanni Pioggia (G)

Institute for Biomedical Research and Innovation (IRIB), National Research Council of Italy (CNR), 98125 Messina, Italy. Electronic address: giovanni.pioggia@cnr.it.

Sebastiano Gangemi (S)

School and Operative Unit of Allergy and Clinical Immunology, Policlinico "G. Martino", Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy. Electronic address: gangemis@unime.it.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Produits terminaux de la dégradation des protéines › Produits d'oxydation avancée des protéines › Advanced glycation end-products and advanced...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Advanced glycation end-products and advanced...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Produits terminaux de glycation avancée › Advanced glycation end-products and advanced...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Advanced glycation end-products and advanced...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Advanced glycation end-products and advanced...
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Schizophrénie › Advanced glycation end-products and advanced...