Role of human salivary enzymes in bitter taste perception.
Bitter
Enzymes
Glutathione transferases
Saliva
Taste
Journal
Food chemistry
ISSN: 1873-7072
Titre abrégé: Food Chem
Pays: England
ID NLM: 7702639
Informations de publication
Date de publication:
30 Aug 2022
30 Aug 2022
Historique:
received:
15
12
2021
revised:
18
03
2022
accepted:
22
03
2022
pubmed:
29
3
2022
medline:
6
5
2022
entrez:
28
3
2022
Statut:
ppublish
Résumé
The molecules that elicit taste sensation are perceived by interacting with the taste receptors located in the taste buds. Enzymes involved in the detoxification processes are found in saliva as well as in type II cells, where taste receptors, including bitter taste receptors, are located. These enzymes are known to interact with a large panel of molecules. To explore a possible link between these enzymes and bitter taste perception, we demonstrate that salivary glutathione transferases (GSTA1 and GSTP1) can metabolize bitter molecules. To support these abilities, we solve three X-ray structures of these enzymes in complexes with isothiocyanates. Salivary GSTA1 and GSTP1 are expressed in a large panel of subjects. Additionally, GSTA1 levels in the saliva of people suffering from taste disorders are significantly lower than those in the saliva of the control group.
Identifiants
pubmed: 35344726
pii: S0308-8146(22)00760-9
doi: 10.1016/j.foodchem.2022.132798
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
132798Informations de copyright
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