Expression of p16
HPV
Immunostaining
South India
keratinizing
oropharyngeal
p16
squamous cell carcinoma
Journal
The Indian journal of medical research
ISSN: 0971-5916
Titre abrégé: Indian J Med Res
Pays: India
ID NLM: 0374701
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
entrez:
28
3
2022
pubmed:
29
3
2022
medline:
12
4
2022
Statut:
ppublish
Résumé
Human papillomavirus (HPV) and oropharyngeal squamous cell carcinoma (OPSCC) are found to be strongly associated with each other with an increase in incidence has been noted globally over the years. A literature search for data depicting the role of HPV in oropharyngeal carcinoma in South India, however, has resulted in little information, thus, the present study was aimed to assess a possible association between the two among OPSCC patients from a tertiary care cancer centre in South India. One hundred and fourty three OPSCC cases were included in the study and analyzed for age, gender, marital status, habits, clinical TNM staging, site, laterality, symptoms, histological type (keratinizing and non-keratinizing), primary treatment and follow up period. All the cases were subjected to p16 Of the 143 cases 12 were found to be p16 positive with no significant difference between the study variables among p16 positive and negative cases. Base of the tongue was the most commonly involved site for the p16 positive cases. The p16 positive cases presented at an elderly age, early stage and were mainly the keratinizing type. The p16 positive OPSCC cases constituted a small proportion in the present study and behaved similar to p16 negative cases. Usage of tobacco and alcohol appear to be the susceptible factors even in p16 positive cases. More studies from other States would be helpful to determine if HPV-related SCC in the Indian subcontinent behave differently or similarly to cases from Western countries.
Sections du résumé
Background & objectives
UNASSIGNED
Human papillomavirus (HPV) and oropharyngeal squamous cell carcinoma (OPSCC) are found to be strongly associated with each other with an increase in incidence has been noted globally over the years. A literature search for data depicting the role of HPV in oropharyngeal carcinoma in South India, however, has resulted in little information, thus, the present study was aimed to assess a possible association between the two among OPSCC patients from a tertiary care cancer centre in South India.
Methods
UNASSIGNED
One hundred and fourty three OPSCC cases were included in the study and analyzed for age, gender, marital status, habits, clinical TNM staging, site, laterality, symptoms, histological type (keratinizing and non-keratinizing), primary treatment and follow up period. All the cases were subjected to p16
Results
UNASSIGNED
Of the 143 cases 12 were found to be p16 positive with no significant difference between the study variables among p16 positive and negative cases. Base of the tongue was the most commonly involved site for the p16 positive cases. The p16 positive cases presented at an elderly age, early stage and were mainly the keratinizing type.
Interpretation & conclusions
UNASSIGNED
The p16 positive OPSCC cases constituted a small proportion in the present study and behaved similar to p16 negative cases. Usage of tobacco and alcohol appear to be the susceptible factors even in p16 positive cases. More studies from other States would be helpful to determine if HPV-related SCC in the Indian subcontinent behave differently or similarly to cases from Western countries.
Identifiants
pubmed: 35345076
pii: IndianJMedRes_2021_154_3_497_340468
doi: 10.4103/ijmr.IJMR_386_19
pmc: PMC9131790
doi:
Substances chimiques
Cyclin-Dependent Kinase Inhibitor p16
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
497-503Références
Indian J Cancer. 2016 Jul-Sep;53(3):387-393
pubmed: 28244466
Am J Surg Pathol. 2013 Sep;37(9):1349-56
pubmed: 23797720
Head Neck. 2014 Apr;36(4):505-10
pubmed: 23729189
Head Neck Pathol. 2009 Sep;3(3):186-94
pubmed: 20596971
Diagnostics (Basel). 2017 Mar 01;7(1):
pubmed: 28257064
Indian J Surg Oncol. 2016 Dec;7(4):386-391
pubmed: 27872524
Head Neck Pathol. 2012 Jul;6 Suppl 1:S75-82
pubmed: 22782226
Semin Diagn Pathol. 2015 Jan;32(1):23-31
pubmed: 25804342
Int J Cancer. 2016 Feb 15;138(4):912-7
pubmed: 26317688
Radiother Oncol. 2012 Nov;105(2):269-70
pubmed: 23127771
Am J Surg Pathol. 2014 Jun;38(6):809-15
pubmed: 24698966
Int J Cancer. 2004 Dec 20;112(6):1015-9
pubmed: 15386365
Clin Transl Oncol. 2014 Mar;16(3):301-6
pubmed: 23828503
J Oral Pathol Med. 2017 Sep;46(8):574-582
pubmed: 27935119
Oral Oncol. 2018 Aug;83:147-153
pubmed: 30098771
Cancer Prev Res (Phila). 2013 Sep;6(9):917-24
pubmed: 23966202
Cancer Lett. 2005 Feb 10;218(2):199-206
pubmed: 15670897
Int J Cancer. 2017 Aug 15;141(4):664-670
pubmed: 28369882