Prevalence of restless legs syndrome in people with diabetes mellitus: A pooling analysis of observational studies.
Diabetes
Diabetes mellitus
Diabetic peripheral neuropathy
Meta-analysis
Restless legs syndrome
Journal
EClinicalMedicine
ISSN: 2589-5370
Titre abrégé: EClinicalMedicine
Pays: England
ID NLM: 101733727
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
12
05
2021
revised:
23
02
2022
accepted:
03
03
2022
pubmed:
30
3
2022
medline:
30
3
2022
entrez:
29
3
2022
Statut:
epublish
Résumé
Diabetes mellitus (DM) is associated with different clinical complications. The aim of this study was to explore the prevalence of RLS in people with diabetes mellitus and compare the risk of restless leg syndrome (RLS) between diabetic and non-diabetic population. We searched for studies of RLS prevalence in DM through PubMed, Embase, and Web of Science. Two authors independently completed the literature screening, data extraction, and bias risk assessment of eligible studies. All observational studies that assessed the prevalence or risk of RLS in DM were included, where the diagnosis of RLS was based on the International Restless Legs Syndrome Study Group (IRLSSG). Percentages, odds ratio (OR) with 95% confidence intervals (CI) were used to assess pooled estimates of RLS prevalence and risk based on random-effects models. Newcastle-Ottawa-scale (NOS) or a modified NOS were used to evaluate the quality of studies. A total of 42 studies, including 835,986 participants, met the eligibility criteria for the meta-analysis. Among them, 30 studies were included in meta-analysis to analyze the prevalence of RLS. A second meta-analysis was conducted using 31 studies to determine RLS risk between diabetes and non-diabetes. The results indicate that between 25% (95% confidence interval 21%-29%) of people with diabetes showed signs of RLS, and people with diabetes had an increased risk of developing RLS compare to people without diabetes (OR 1.98, 95%CI 1.66- 2.34, Our study suggests that the prevalence and risk of RLS might be higher in DM patients than in non-diabetes population. However, given limitations in the analysis and study design, the findings need to be corroborated in future studies. This work was supported by the Basic Conditions Platform Construction Project of Sichuan Science and Technology Department (2019JDPT0015), and the "1・3・5 project for disciplines of excellence, West China Hospital, Sichuan University" (ZYJC18003).
Sections du résumé
Background
UNASSIGNED
Diabetes mellitus (DM) is associated with different clinical complications. The aim of this study was to explore the prevalence of RLS in people with diabetes mellitus and compare the risk of restless leg syndrome (RLS) between diabetic and non-diabetic population.
Methods
UNASSIGNED
We searched for studies of RLS prevalence in DM through PubMed, Embase, and Web of Science. Two authors independently completed the literature screening, data extraction, and bias risk assessment of eligible studies. All observational studies that assessed the prevalence or risk of RLS in DM were included, where the diagnosis of RLS was based on the International Restless Legs Syndrome Study Group (IRLSSG). Percentages, odds ratio (OR) with 95% confidence intervals (CI) were used to assess pooled estimates of RLS prevalence and risk based on random-effects models. Newcastle-Ottawa-scale (NOS) or a modified NOS were used to evaluate the quality of studies.
Findings
UNASSIGNED
A total of 42 studies, including 835,986 participants, met the eligibility criteria for the meta-analysis. Among them, 30 studies were included in meta-analysis to analyze the prevalence of RLS. A second meta-analysis was conducted using 31 studies to determine RLS risk between diabetes and non-diabetes. The results indicate that between 25% (95% confidence interval 21%-29%) of people with diabetes showed signs of RLS, and people with diabetes had an increased risk of developing RLS compare to people without diabetes (OR 1.98, 95%CI 1.66- 2.34,
Interpretation
UNASSIGNED
Our study suggests that the prevalence and risk of RLS might be higher in DM patients than in non-diabetes population. However, given limitations in the analysis and study design, the findings need to be corroborated in future studies.
Funding
UNASSIGNED
This work was supported by the Basic Conditions Platform Construction Project of Sichuan Science and Technology Department (2019JDPT0015), and the "1・3・5 project for disciplines of excellence, West China Hospital, Sichuan University" (ZYJC18003).
Identifiants
pubmed: 35345532
doi: 10.1016/j.eclinm.2022.101357
pii: S2589-5370(22)00087-6
pmc: PMC8956955
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101357Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no potential conflicts of interest.
Références
Acta Neurol Scand. 2010 Jul;122(1):63-9
pubmed: 19951275
FP Essent. 2017 Sep;460:29-32
pubmed: 28845959
Sleep Med. 2003 Mar;4(2):101-19
pubmed: 14592341
Diabetes Educ. 2010 Jan-Feb;36(1):79-87
pubmed: 20185611
Neurol Sci. 2018 Nov;39(11):1927-1934
pubmed: 30116981
Exp Clin Endocrinol Diabetes. 2009 Oct;117(9):496-9
pubmed: 19536737
Cardiovasc Diabetol. 2021 Jan 30;20(1):30
pubmed: 33516224
Neurol Sci. 2015 May;36(5):723-7
pubmed: 25471049
BMJ. 1997 Dec 6;315(7121):1533-7
pubmed: 9432252
Diabetes Care. 2000 Sep;23(9):1353-8
pubmed: 10977032
J Heart Lung Transplant. 2007 Jan;26(1):24-9
pubmed: 17234513
Prim Care Diabetes. 2019 Feb;13(1):87-91
pubmed: 30213520
Neurology. 2021 Aug 17;97(7):e695-e705
pubmed: 34321360
Contemp Clin Trials. 2015 Nov;45(Pt A):139-45
pubmed: 26343745
Sleep Med. 2007 Nov;8(7-8):768-72
pubmed: 17825613
J Clin Sleep Med. 2015 Oct 15;11(10):1121-30
pubmed: 26156957
Arq Neuropsiquiatr. 2018 Dec;76(12):827-830
pubmed: 30698206
Diabetes Educ. 2008 Mar-Apr;34(2):218-34
pubmed: 18375774
Ren Fail. 2016;38(2):194-7
pubmed: 26554439
J Sleep Res. 2016 Feb;25(1):47-56
pubmed: 26377112
Eur J Epidemiol. 2010 Sep;25(9):603-5
pubmed: 20652370
EClinicalMedicine. 2021 Jul 14;38:101016
pubmed: 34308317
Neurology. 2005 Jun 14;64(11):1920-4
pubmed: 15955944
J Clin Psychopharmacol. 2014 Feb;34(1):159-61
pubmed: 24135842
Arch Gerontol Geriatr. 2016 Jul-Aug;65:29-35
pubmed: 26945639
Saudi J Kidney Dis Transpl. 2009 May;20(3):378-85
pubmed: 19414938
Sleep Med. 2014 Aug;15(8):860-73
pubmed: 25023924
J Clin Sleep Med. 2018 Feb 15;14(2):223-228
pubmed: 29351820
BMJ Support Palliat Care. 2016 Mar;6(1):89-93
pubmed: 25216659
Saudi J Kidney Dis Transpl. 2016 Mar;27(2):326-30
pubmed: 26997386
Sleep Med. 2017 Aug;36:6-9
pubmed: 28735923
Prev Chronic Dis. 2012;9:E76
pubmed: 22440550
Sleep Med. 2019 Jan;53:81-87
pubmed: 30458382
J Peripher Nerv Syst. 2007 Mar;12(1):50-3
pubmed: 17374101
Sleep Med. 2004 May;5(3):293-9
pubmed: 15165538
Climacteric. 2008 Oct;11(5):422-8
pubmed: 18781488
Dis Esophagus. 2017 Jun 1;30(6):1-12
pubmed: 28475743
Sleep Med. 2001 Sep;2(5):417-22
pubmed: 14592391
Sleep Med. 2004 Jul;5(4):385-91
pubmed: 15222997
Postgrad Med. 2013 May;125(3):99-111
pubmed: 23748511
Med Arch. 2016 Apr;70(2):116-8
pubmed: 27147785
Physiol Res. 2003;52(6):735-41
pubmed: 14640895
Eur J Neurol. 2014;21(1):72-8
pubmed: 23906194
J Sleep Res. 2013 Aug;22(4):434-42
pubmed: 23374090
Am J Med. 2013 Mar;126(3):228-35, 235.e1-2
pubmed: 23410563
J Neurol. 2002 Sep;249(9):1195-9
pubmed: 12242538
Neurology. 2008 Jan 1;70(1):35-42
pubmed: 18166705
Sleep. 2008 Jul;31(7):944-52
pubmed: 18655317
BMJ. 2009 Jul 21;339:b2535
pubmed: 19622551
Sleep Med. 2012 Apr;13(4):342-5
pubmed: 22172960
Mov Disord. 1995 Sep;10(5):634-42
pubmed: 8552117
J Family Med Prim Care. 2019 Feb;8(2):432-436
pubmed: 30984650
Sleep Med. 2018 Oct;50:97-104
pubmed: 30025277
J Korean Med Sci. 2019 Apr 29;34(16):e130
pubmed: 31020817
Eur J Neurol. 2013 Jul;20(7):1025-31
pubmed: 23369046
Am J Med. 2013 Mar;126(3):220-7, 227.e1-2
pubmed: 23410562
Arq Bras Endocrinol Metabol. 2013 Aug;57(6):425-30
pubmed: 24030181
Sleep Disord. 2014;2014:871751
pubmed: 24895540
Sleep. 2007 Jul;30(7):866-71
pubmed: 17682657
Diabetes Care. 2005 Nov;28(11):2633-6
pubmed: 16249531
Endocrine. 2013 Aug;44(1):125-31
pubmed: 23203003
Sleep Med. 2013 Dec;14(12):1387-92
pubmed: 24210603
Lancet Neurol. 2005 Aug;4(8):465-75
pubmed: 16033689
Sleep Med. 2010 Jan;11(1):82-6
pubmed: 19403331
PLoS One. 2010 Mar 01;5(3):e9444
pubmed: 20209158
Eur J Neurol. 2002 Nov;9 Suppl 3:59-67
pubmed: 12464123
Neuropediatrics. 2005 Apr;36(2):98-103
pubmed: 15822022
Sleep Med. 2018 Mar;43:40-46
pubmed: 29482811
JAMA Neurol. 2019 Feb 1;76(2):144-151
pubmed: 30419085
Tumour Biol. 2016 Sep;37(9):12525-12533
pubmed: 27344157
J Diabetes Complications. 2020 Dec;34(12):107727
pubmed: 32921575
Neurology. 2021 Jan 26;96(4):e513-e526
pubmed: 33277416
BMJ. 2003 Sep 6;327(7414):557-60
pubmed: 12958120