High risk factors for craniosynostosis during pregnancy: A case-control study.
Birth defects
Children
Craniosynostosis
Pregnancy
Progesterone
Risk factor
Journal
European journal of obstetrics & gynecology and reproductive biology: X
ISSN: 2590-1613
Titre abrégé: Eur J Obstet Gynecol Reprod Biol X
Pays: Netherlands
ID NLM: 101750520
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
22
12
2021
revised:
12
03
2022
accepted:
16
03
2022
entrez:
29
3
2022
pubmed:
30
3
2022
medline:
30
3
2022
Statut:
epublish
Résumé
Craniosynostosis is a birth defect involving premature cranial sutures' fusion with an increasing prevalence and unknown underlying causes in nearly 80% of cases. The current study investigates a series of high-risk factors associated with a non-syndromic craniosynostosis. Ninety-seven (97) children were included in the retrospective case-control study, 62 controls and 35 with craniosynostosis. A questionnaire with 143 questions was used in face-to-face interviews. After univariate analyses, stepwise multivariate logistic regression analysis was implemented. In craniosynostosis group, 3 out of 4 were male subjects and 2 out of 3 born with caesarian section. History for central nervous system abnormalities in their younger siblings, low birth weight, extended use of mobile phone from the parents and medications' use differed significantly between craniosynostosis and control group. After adjustment for all factors, only maternal medication use (aOR 6,1 [2.1 - 19], CI 95%) and oral progesterone intake (aOR 4 [1.2 - 14], CI 95%) were significantly associated with an increased risk in craniosynostosis group. The maternal medications' use and particular oral progesterone intake is associated with an increased risk for non-syndromic craniosynostosis. However, due to the study's limitations, further research is warranted.
Sections du résumé
Background
UNASSIGNED
Craniosynostosis is a birth defect involving premature cranial sutures' fusion with an increasing prevalence and unknown underlying causes in nearly 80% of cases. The current study investigates a series of high-risk factors associated with a non-syndromic craniosynostosis.
Methods
UNASSIGNED
Ninety-seven (97) children were included in the retrospective case-control study, 62 controls and 35 with craniosynostosis. A questionnaire with 143 questions was used in face-to-face interviews. After univariate analyses, stepwise multivariate logistic regression analysis was implemented.
Results
UNASSIGNED
In craniosynostosis group, 3 out of 4 were male subjects and 2 out of 3 born with caesarian section. History for central nervous system abnormalities in their younger siblings, low birth weight, extended use of mobile phone from the parents and medications' use differed significantly between craniosynostosis and control group. After adjustment for all factors, only maternal medication use (aOR 6,1 [2.1 - 19], CI 95%) and oral progesterone intake (aOR 4 [1.2 - 14], CI 95%) were significantly associated with an increased risk in craniosynostosis group.
Conclusion
UNASSIGNED
The maternal medications' use and particular oral progesterone intake is associated with an increased risk for non-syndromic craniosynostosis. However, due to the study's limitations, further research is warranted.
Identifiants
pubmed: 35345771
doi: 10.1016/j.eurox.2022.100147
pii: S2590-1613(22)00007-2
pmc: PMC8956885
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100147Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
None.
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