Ileal and colonic Crohn's disease: Does location makes a difference in therapy efficacy?
Colonic Crohn's disease
Crohn's disease
Ileal Crohn's disease
Segment
Therapy
Journal
Current research in pharmacology and drug discovery
ISSN: 2590-2571
Titre abrégé: Curr Res Pharmacol Drug Discov
Pays: Netherlands
ID NLM: 9918300982506676
Informations de publication
Date de publication:
2022
2022
Historique:
received:
06
12
2021
revised:
07
03
2022
accepted:
16
03
2022
entrez:
29
3
2022
pubmed:
30
3
2022
medline:
30
3
2022
Statut:
epublish
Résumé
Within the IBD entity of Crohn's disease, there is currently no differentiation between ileal and colonic manifestation for recruitment of patients in clinical trials, well-powered analysis of study results or therapeutic decisions in daily clinical practice. However, there is accumulating evidence from epidemiological, genetic, microbial, immunological, and clinical characteristics that clearly indicate that ileal Crohn's disease represents a distinct disease entity, which differentiates itself from colonic Crohn's disease. This is also reflected by lower efficacy of targeted therapies in isolated ileal compared to colonic Crohn's disease. The distinct site-specific mechanisms that drive heightened non-response in ileal disease need to be analysed in-depth in the future, to enable optimized therapy in the individual Crohn's disease patient.
Identifiants
pubmed: 35345820
doi: 10.1016/j.crphar.2022.100097
pii: S2590-2571(22)00017-7
pmc: PMC8956925
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
100097Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: RA has served as a speaker, or consultant, or received research grants from AbbVie, Amgen, Arena Pharmaceuticals, Biogen, Boehringer Ingelheim, Bristol-Myers Squibb, Cellgene, Celltrion Healthcare, DrFalk Pharma, Ferring, Fresenius Kabi, Galapagos, Gilead, InDex Pharmaceuticals, Janssen-Cilag, Kliniksa Pharmaceuticals, Lilly, MSD Sharp & Dohme, Novartis, Pandion Therapeutics, Pfizer, Roche Pharma, Samsung Bioepsis, Takeda Pharma, Tillotts Pharma AG, Viatris. Research work of RA is funded by the DFG-SFB1181 (Project No. C02) and DFG-SFB/TRR241 (Project No. C02, C03, IBDome). Research work of CB is funded by DFG-SFB/TRR241 (Project No. C02). Research work of AAK, ZT is funded by the DFG-SFB/TRR241 (IBDome), and research work of AAK and BS is funded by DFG SFB1340-TPB06. MFN reports research grants and/or personal fees from Abbvie, MSD, Takeda, Boehringer, Roche, Pfizer, Janssen, Pentax and PPD. BS has served as a consultant for Abbvie, Arena, BMS, Boehringer, Celgene, Falk, Galapagos, Janssen, Lilly, Pfizer, Prometheus, Takeda and has received speaker's fees from Abbvie, CED Service GmbH, Falk, Ferring, Janssen, Novartis, Pfizer, and Takeda as a representative of Charité – Universitätsmedizin Berlin.
Références
Nat Rev Gastroenterol Hepatol. 2021 Aug;18(8):544-558
pubmed: 33712743
N Engl J Med. 2010 Apr 15;362(15):1383-95
pubmed: 20393175
N Engl J Med. 2016 Nov 17;375(20):1946-1960
pubmed: 27959607
J Crohns Colitis. 2017 Jan;11(1):3-25
pubmed: 27660341
Inflamm Bowel Dis. 2017 Mar;23(3):379-391
pubmed: 28221249
J Crohns Colitis. 2017 Apr 01;11(4):425-434
pubmed: 27815351
Gut. 2019 May;68(5):814-828
pubmed: 29848778
Gut. 2007 Sep;56(9):1232-9
pubmed: 17299059
Gastroenterology. 2002 Apr;122(4):867-74
pubmed: 11910337
Am J Gastroenterol. 2020 Aug;115(8):1236-1245
pubmed: 32759621
J Crohns Colitis. 2021 Nov 10;:
pubmed: 34758084
Gut. 2006 Jun;55(6):749-53
pubmed: 16698746
Dig Dis Sci. 2005 Aug;50(8):1471-5
pubmed: 16110838
Clin Gastroenterol Hepatol. 2020 Jun;18(7):1545-1552
pubmed: 31442600
Front Immunol. 2021 Mar 30;12:622934
pubmed: 33859636
Gut. 2009 Dec;58(12):1612-9
pubmed: 19700435
Aliment Pharmacol Ther. 2003 Jun 15;17(12):1451-7
pubmed: 12823146
World J Gastroenterol. 2012 Feb 7;18(5):412-24
pubmed: 22346247
Gastroenterology. 1979 Oct;77(4 Pt 2):847-69
pubmed: 38176
Front Med (Lausanne). 2020 Sep 02;7:517
pubmed: 32984386
Gastroenterology. 2018 Sep;155(3):687-695.e10
pubmed: 29857091
Gastroenterology. 2007 Jan;132(1):52-65
pubmed: 17241859
Inflamm Bowel Dis. 2003 Sep;9(5):281-9
pubmed: 14555911
Inflamm Bowel Dis. 2010 Dec;16(12):2090-8
pubmed: 20848504
Inflamm Bowel Dis. 2012 Jan;18(1):10-6
pubmed: 21456032
Gastroenterology. 2002 Jul;123(1):33-40
pubmed: 12105831
Inflamm Bowel Dis. 2004 May;10(3):318-20
pubmed: 15290929
J Crohns Colitis. 2016 Jul;10(7):795-804
pubmed: 26822611
Clin Gastroenterol Hepatol. 2018 Sep;16(9):1407-1419.e22
pubmed: 29596987
Aliment Pharmacol Ther. 2021 Sep;54(6):779-791
pubmed: 34297423
J Crohns Colitis. 2019 Oct 28;13(11):1401-1409
pubmed: 30989232
J Crohns Colitis. 2017 Jun 1;11(6):649-670
pubmed: 28158501
Am J Gastroenterol. 2021 Jan 1;116(1):134-141
pubmed: 33177349
Clin Gastroenterol Hepatol. 2019 Dec;17(13):2634-2643
pubmed: 31009791
N Engl J Med. 2013 Aug 22;369(8):711-21
pubmed: 23964933
Clin Nutr. 2019 Aug;38(4):1629-1635
pubmed: 30193873
Gastroenterology. 2006 Feb;130(2):323-33; quiz 591
pubmed: 16472588
Inflamm Bowel Dis. 2017 May;23(5):833-839
pubmed: 28328624
Lancet. 2002 May 4;359(9317):1541-9
pubmed: 12047962
Therap Adv Gastroenterol. 2020 Dec 21;13:1756284820976923
pubmed: 33425009
Am J Gastroenterol. 2002 Sep;97(9):2357-63
pubmed: 12358256
Gut. 1991 Sep;32(9):1071-5
pubmed: 1916494
N Engl J Med. 1997 Oct 9;337(15):1029-35
pubmed: 9321530
N Engl J Med. 2012 Oct 18;367(16):1519-28
pubmed: 23075178
Clin Gastroenterol Hepatol. 2011 Aug;9(8):670-678.e3
pubmed: 21642014
Gastroenterol Hepatol (N Y). 2011 May;7(5):295-301
pubmed: 21857830
Gut. 2017 Feb;66(2):362-381
pubmed: 27802156
Nat Rev Gastroenterol Hepatol. 2020 Jan;17(1):9-20
pubmed: 31767987
Gastroenterology. 2019 Oct;157(4):1007-1018.e7
pubmed: 31279871
J Crohns Colitis. 2022 Jan 28;16(1):27-38
pubmed: 34402887
Cell. 2019 Sep 5;178(6):1493-1508.e20
pubmed: 31474370
Gastroenterol Clin Biol. 2005 Feb;29(2):145-9
pubmed: 15795662
Aliment Pharmacol Ther. 2020 Sep;52(6):1017-1030
pubmed: 32770851
Lancet. 2017 Apr 29;389(10080):1699-1709
pubmed: 28411872
Lancet Gastroenterol Hepatol. 2018 Nov;3(11):790-802
pubmed: 30353856