Genome-wide association analysis reveal the genetic reasons affect melanin spot accumulation in beak skin of ducks.
Beak skin melanin spot
Duck
GWAS
Genetic
Journal
BMC genomics
ISSN: 1471-2164
Titre abrégé: BMC Genomics
Pays: England
ID NLM: 100965258
Informations de publication
Date de publication:
26 Mar 2022
26 Mar 2022
Historique:
received:
10
06
2021
accepted:
25
01
2022
entrez:
29
3
2022
pubmed:
30
3
2022
medline:
31
3
2022
Statut:
epublish
Résumé
Skin pigmentation is a broadly appearing phenomenon of most animals and humans in nature. Here we used a bird model to investigate why melanin spot deposits on the skin. Our result showed that growth age and the sunlight might induce melanin deposition in bird beak skin which was determined by genetic factors. GWAS helped us to identify two major loci affecting melanin deposition, located on chromosomes 13 and 25, respectively. The fine mapping works narrowed the candidate regions to 0.98 Mb and 1.0 Mb on chromosomes 13 and 25. The MITF and POU2F3 may be the causative genes and synergistically affect melanin deposition during duck beak skin. Furthermore, our data strongly demonstrated that the pathway of melanin metabolism contributes to melanin deposition on the skin. We demonstrated that age and sunlight induce melanin deposition in bird beak skin, while heredity is fundamental. The MITF and POU2F3 likely played a synergistic effect on the regulation of melanin synthesis, and their mutations contribute to phenotypic differences in beak melanin deposition among individuals. It is pointed out that melanin deposition in the skin is related to the pathway of melanin metabolism, which provided insights into the molecular regulatory mechanisms and the genetic improvement of the melanin deposition in duck beak.
Sections du résumé
BACKGROUND
BACKGROUND
Skin pigmentation is a broadly appearing phenomenon of most animals and humans in nature. Here we used a bird model to investigate why melanin spot deposits on the skin.
RESULTS
RESULTS
Our result showed that growth age and the sunlight might induce melanin deposition in bird beak skin which was determined by genetic factors. GWAS helped us to identify two major loci affecting melanin deposition, located on chromosomes 13 and 25, respectively. The fine mapping works narrowed the candidate regions to 0.98 Mb and 1.0 Mb on chromosomes 13 and 25. The MITF and POU2F3 may be the causative genes and synergistically affect melanin deposition during duck beak skin. Furthermore, our data strongly demonstrated that the pathway of melanin metabolism contributes to melanin deposition on the skin.
CONCLUSIONS
CONCLUSIONS
We demonstrated that age and sunlight induce melanin deposition in bird beak skin, while heredity is fundamental. The MITF and POU2F3 likely played a synergistic effect on the regulation of melanin synthesis, and their mutations contribute to phenotypic differences in beak melanin deposition among individuals. It is pointed out that melanin deposition in the skin is related to the pathway of melanin metabolism, which provided insights into the molecular regulatory mechanisms and the genetic improvement of the melanin deposition in duck beak.
Identifiants
pubmed: 35346029
doi: 10.1186/s12864-022-08444-5
pii: 10.1186/s12864-022-08444-5
pmc: PMC8962612
doi:
Substances chimiques
Melanins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
236Subventions
Organisme : National Natural Science Foundation of China
ID : 31972523
Organisme : National Natural Science Foundation of China
ID : 31972523
Organisme : National Scientific Supporting Projects of China2015BAD03B06
ID : 2015BAD03B06
Organisme : National Scientific Supporting Projects of China2015BAD03B06
ID : 2015BAD03B06
Organisme : China Agriculture Research System of Waterfow
ID : CARS-42
Organisme : China Agriculture Research System of Waterfow
ID : CARS-42
Organisme : CAAS Innovation Team Project
ID : ASTIP-2016-IAS-9
Organisme : CAAS Innovation Team Project
ID : ASTIP-2016-IAS-9
Informations de copyright
© 2022. The Author(s).
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