Association of

Case-Control Studies Genetic Predisposition to Disease Genotype Helicobacter Infections / complications Humans Matrix Metalloproteinase 2 / genetics Polymorphism, Single Nucleotide Risk Factors Stomach Neoplasms / epidemiology Taiwan / epidemiology
Gastric cancer MMP-2 Taiwan genotype polymorphism

Journal

Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988

Informations de publication

Date de publication:
04 2022
Historique:
received: 24 01 2022
revised: 09 02 2022
accepted: 10 02 2022
entrez: 29 3 2022
pubmed: 30 3 2022
medline: 5 4 2022
Statut: ppublish

Résumé

Matrix metalloproteinase-2 (MMP-2) plays a critical role in the regulation of the extracellular matrix; however, its genotypes have seldom been examined in gastric cancer (GC). This study aimed to investigate the contribution of MMP-2 promoter -1306 (rs243865) and -735 (rs2285053) genotypes to GC risk in a cohort of Taiwanese individuals. This study included 121 GC cases and 363 age- and sex-matched controls. The genotypes of MMP-2 were determined by typical polymerase chain reaction-restriction fragment length polymorphism. The genotypic and allelic frequency analysis showed that MMP-2 rs243865 variant genotypes decreased the risk of GC. Stratification analysis showed that MMP-2 rs243865 genotypes associate with smoking, alcohol drinking, and Helicobacter pylori infection status to confer personal susceptibility to GC. There is no such association for MMP-2 rs2285053 genotype with GC risk. The MMP-2 rs243865 genotypes may serve as a novel predictive marker for GC personal susceptibility among Taiwanese.

Sections du résumé

BACKGROUND/AIM
Matrix metalloproteinase-2 (MMP-2) plays a critical role in the regulation of the extracellular matrix; however, its genotypes have seldom been examined in gastric cancer (GC). This study aimed to investigate the contribution of MMP-2 promoter -1306 (rs243865) and -735 (rs2285053) genotypes to GC risk in a cohort of Taiwanese individuals.
MATERIALS AND METHODS
This study included 121 GC cases and 363 age- and sex-matched controls. The genotypes of MMP-2 were determined by typical polymerase chain reaction-restriction fragment length polymorphism.
RESULTS
The genotypic and allelic frequency analysis showed that MMP-2 rs243865 variant genotypes decreased the risk of GC. Stratification analysis showed that MMP-2 rs243865 genotypes associate with smoking, alcohol drinking, and Helicobacter pylori infection status to confer personal susceptibility to GC. There is no such association for MMP-2 rs2285053 genotype with GC risk.
CONCLUSION
The MMP-2 rs243865 genotypes may serve as a novel predictive marker for GC personal susceptibility among Taiwanese.

Identifiants

DOI: 10.21873/anticanres.15651 PMID: 35346993
pubmed: 35346993
pii: 42/4/1749
doi: 10.21873/anticanres.15651
doi:

Substances chimiques

MMP2 protein, human EC 3.4.24.24
Matrix Metalloproteinase 2 EC 3.4.24.24

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1749-1755

Informations de copyright

Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Auteurs

Chun-Kai Fu (CK)

Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.
Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
National Defense Medical Center, Taipei, Taiwan, R.O.C.

Mei-Chin Mong (MC)

Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C.

Chien-Chih Yu (CC)

Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.

Mei-Due Yang (MD)

Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.

Zhi-Hong Wang (ZH)

Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C.

Ya-Chen Yang (YC)

Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C.

Jaw-Chyun Chen (JC)

Department of Medicinal Botanicals and Health Applications, Da-Yeh University, Changhua, Taiwan, R.O.C.

Jen-Sheng Pei (JS)

Department of Pediatrics, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, R.O.C.

Ning-Yi Hsia (NY)

Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.

Chia-Wen Tsai (CW)

Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.

Wen-Shin Chang (WS)

Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.; artbau2@gmail.com halittlemelon@hotmail.com.
Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.

DA-Tian Bau (DT)

Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.; artbau2@gmail.com halittlemelon@hotmail.com.
Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, R.O.C.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Association of
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Association of
questionsmedicales.fr › Phénomènes génétiques › Génotype › Association of
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Helicobacter › Association of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Association of
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Secreted matrix metalloproteinases › Matrix metalloproteinase 2 › Association of
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Association of
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Association of
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies de l'estomac › Tumeurs de l'estomac › Association of
questionsmedicales.fr › Régions géographiques › Iles › Taïwan › Association of