Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine.
artificial intelligence
deep learning
drug discovery
multi-omics
target identification
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
29 03 2022
29 03 2022
Historique:
received:
21
01
2022
accepted:
06
03
2022
pubmed:
30
3
2022
medline:
8
4
2022
entrez:
29
3
2022
Statut:
ppublish
Résumé
Aging biology is a promising and burgeoning research area that can yield dual-purpose pathways and protein targets that may impact multiple diseases, while retarding or possibly even reversing age-associated processes. One widely used approach to classify a multiplicity of mechanisms driving the aging process is the hallmarks of aging. In addition to the classic nine hallmarks of aging, processes such as extracellular matrix stiffness, chronic inflammation and activation of retrotransposons are also often considered, given their strong association with aging. In this study, we used a variety of target identification and prioritization techniques offered by the AI-powered PandaOmics platform, to propose a list of promising novel aging-associated targets that may be used for drug discovery. We also propose a list of more classical targets that may be used for drug repurposing within each hallmark of aging. Most of the top targets generated by this comprehensive analysis play a role in inflammation and extracellular matrix stiffness, highlighting the relevance of these processes as therapeutic targets in aging and age-related diseases. Overall, our study reveals both high confidence and novel targets associated with multiple hallmarks of aging and demonstrates application of the PandaOmics platform to target discovery across multiple disease areas.
Identifiants
pubmed: 35347083
pii: 203960
doi: 10.18632/aging.203960
pmc: PMC9004567
doi:
Substances chimiques
Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2475-2506Références
Mol Cell Biol. 2005 Jun;25(12):5292-305
pubmed: 15923642
Bioinformatics. 2020 Apr 1;36(7):2202-2208
pubmed: 31845988
F1000Res. 2019 Jul 2;8:
pubmed: 31316753
Aging (Albany NY). 2020 Mar 31;12(8):6492-6510
pubmed: 32229705
Int J Mol Sci. 2020 Nov 17;21(22):
pubmed: 33213069
Clin Proteomics. 2015 Jan 13;12(1):1
pubmed: 25678896
Mol Cell Biol. 2009 Jul;29(14):3867-80
pubmed: 19398579
EMBO J. 2017 Apr 3;36(7):840-853
pubmed: 28254837
Am J Pathol. 2009 Jun;174(6):2073-85
pubmed: 19465643
Calcif Tissue Int. 2017 Jun;100(6):599-608
pubmed: 28246930
Int J Mol Sci. 2020 Sep 19;21(18):
pubmed: 32961796
Aging Cell. 2005 Dec;4(6):291-8
pubmed: 16300481
Elife. 2018 May 02;7:
pubmed: 29717979
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
Blood. 2011 Jan 13;117(2):429-39
pubmed: 20833981
J Cell Biol. 2010 Dec 27;191(7):1299-313
pubmed: 21187328
Nat Rev Cardiol. 2018 Sep;15(9):505-522
pubmed: 30065258
Biochim Biophys Acta. 2001 Dec 30;1522(3):221-5
pubmed: 11779638
Aging Cell. 2014 Dec;13(6):981-1000
pubmed: 25244225
Cell. 2014 Nov 6;159(4):709-13
pubmed: 25417146
J Cell Biol. 2018 Jan 2;217(1):79-92
pubmed: 29070608
Drug Discov Today. 2007 Mar;12(5-6):218-24
pubmed: 17331886
Ageing Res Rev. 2020 Jul;60:101050
pubmed: 32272169
Matrix Biol. 2018 Sep;70:140-157
pubmed: 29649548
Nat Rev Drug Discov. 2020 Aug;19(8):513-532
pubmed: 32467649
Sci Rep. 2016 Nov 25;6:37827
pubmed: 27886253
Nat Med. 2015 Dec;21(12):1424-35
pubmed: 26646499
Front Endocrinol (Lausanne). 2018 Oct 15;9:614
pubmed: 30374331
Cell. 1996 Nov 29;87(5):953-9
pubmed: 8945521
J Cell Commun Signal. 2018 Mar;12(1):35-43
pubmed: 29455303
Cell Cycle. 2014;13(7):1063-77
pubmed: 24603410
Oncotarget. 2017 Dec 28;9(8):7796-7811
pubmed: 29487692
Cell. 2006 Jul 28;126(2):257-68
pubmed: 16873059
Nat Rev Drug Discov. 2010 Mar;9(3):203-14
pubmed: 20168317
Trends Endocrinol Metab. 2022 Apr;33(4):266-280
pubmed: 35183431
Mech Ageing Dev. 2017 Sep;166:6-15
pubmed: 28843433
N Engl J Med. 1999 Jan 14;340(2):115-26
pubmed: 9887164
Aging (Albany NY). 2016 Sep 24;8(9):2127-2152
pubmed: 27677171
Am J Physiol Lung Cell Mol Physiol. 2004 Jun;286(6):L1311-8
pubmed: 14977630
Nat Struct Mol Biol. 2013 Sep;20(9):1040-6
pubmed: 23934153
Cell Death Dis. 2017 Jul 20;8(7):e2949
pubmed: 28726776
Nat Rev Drug Discov. 2011 May;10(5):328-9
pubmed: 21532551
Exp Ther Med. 2021 May;21(5):459
pubmed: 33777193
Ageing Res Rev. 2020 Sep;62:101097
pubmed: 32540391
Adv Sci (Weinh). 2020 Sep 30;7(22):2001950
pubmed: 33240758
Trends Cell Biol. 2022 Feb;32(2):110-123
pubmed: 34479765
Ageing Res Rev. 2021 Sep;70:101410
pubmed: 34280555
Cold Spring Harb Perspect Biol. 2011 Nov 01;3(11):a005017
pubmed: 21900405
Cell Death Dis. 2018 Mar 2;9(3):356
pubmed: 29500465
DNA Repair (Amst). 2020 Dec;96:102993
pubmed: 33038659
Aging (Albany NY). 2012 Aug;4(8):553-66
pubmed: 22915705
J Clin Invest. 2018 Dec 3;128(12):5587-5602
pubmed: 30300140
Sci Rep. 2016 Jul 01;6:28889
pubmed: 27363302
Osteoarthritis Cartilage. 2017 Jul;25(7):1000-1009
pubmed: 28216310
Nat Commun. 2016 Nov 16;7:13427
pubmed: 27848968
Nature. 2012 Jul 19;487(7407):325-9
pubmed: 22763456
Trends Biotechnol. 2022 Feb 18;:
pubmed: 35190201
Ageing Res Rev. 2019 Jan;49:49-66
pubmed: 30472217
EBioMedicine. 2018 Feb;28:311-315
pubmed: 29396305
J Cell Mol Med. 2019 Mar;23(3):2149-2162
pubmed: 30614617
J Neurosci. 2007 Mar 28;27(13):3603-11
pubmed: 17392476
Nat Aging. 2021 Oct;1(10):870-879
pubmed: 34841261
BMC Bioinformatics. 2022 Jan 4;23(1):10
pubmed: 34983372
Nucleic Acids Res. 2018 Jan 4;46(D1):D1083-D1090
pubmed: 29121237
Biochem Biophys Res Commun. 2020 Feb 12;522(3):731-735
pubmed: 31791585
Pharmacol Rev. 2012 Jan;64(1):88-101
pubmed: 22090473
Cell Metab. 2014 Mar 4;19(3):373-9
pubmed: 24508508
J Biol Chem. 2019 Nov 8;294(45):16684-16697
pubmed: 31543504
Cytokine. 2019 Nov;123:154783
pubmed: 31336263
Neurobiol Dis. 2007 Mar;25(3):473-82
pubmed: 17188882
Mol Pharm. 2016 Jul 5;13(7):2524-30
pubmed: 27200455
Cell. 2013 Feb 14;152(4):859-72
pubmed: 23415232
EMBO J. 2012 Jan 4;31(1):58-70
pubmed: 22020126
Front Endocrinol (Lausanne). 2020 Nov 16;11:568861
pubmed: 33304318
iScience. 2021 Sep 11;24(10):103118
pubmed: 34622167
Aging (Albany NY). 2015 Sep;7(9):616-28
pubmed: 26342919
J Cell Physiol. 2004 May;199(2):244-51
pubmed: 15040007
Mayo Clin Proc Innov Qual Outcomes. 2021 Jun 23;5(4):783-794
pubmed: 34401655
Aging Cell. 2016 Jun;15(3):407-15
pubmed: 26970234
Subcell Biochem. 2018;90:169-190
pubmed: 30779010
J Immunol. 2012 Jun 1;188(11):5776-84
pubmed: 22547695
Nucleic Acids Res. 2000 Jan 1;28(1):27-30
pubmed: 10592173
Nat Rev Endocrinol. 2018 Oct;14(10):576-590
pubmed: 30046148
Exp Gerontol. 2006 Dec;41(12):1243-6
pubmed: 17071038
Nat Commun. 2020 Nov 13;11(1):5781
pubmed: 33188183
Front Cell Dev Biol. 2021 Jul 19;9:729416
pubmed: 34395453
Mod Pathol. 2022 Feb;35(2):165-176
pubmed: 34389792
Aging Cell. 2019 Dec;18(6):e13041
pubmed: 31560156
Hum Mol Genet. 2016 Nov 1;25(21):4804-4818
pubmed: 28175300
Cardiovasc Res. 2013 Jul 1;99(1):111-20
pubmed: 23619422
Nature. 2021 Aug;596(7870):43-53
pubmed: 34349292
J Neuroinflammation. 2016 May 26;13(1):123
pubmed: 27230771
Aging (Albany NY). 2017 Nov 15;9(11):2245-2268
pubmed: 29165314
Exp Ther Med. 2020 Mar;19(3):1844-1854
pubmed: 32104240
J Bone Miner Res. 1998 Jul;13(7):1101-11
pubmed: 9661074
Drug Discov Today. 2021 Jul;26(7):1559-1562
pubmed: 33617794
Aging (Albany NY). 2017 Jul 18;9(7):1721-1737
pubmed: 28783712
Genome Biol. 2022 Jan 26;23(1):35
pubmed: 35078504
Development. 2003 Mar;130(6):1089-99
pubmed: 12571101
Sci Rep. 2016 Jun 06;6:27354
pubmed: 27264390