Sex differences in esophageal cancer overall and by histological subtype.

Chi-Square Distribution Esophageal Neoplasms / pathology Female Humans Male Prognosis Proportional Hazards Models Sex Characteristics

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
28 03 2022
Historique:
received: 15 11 2021
accepted: 18 03 2022
entrez: 29 3 2022
pubmed: 30 3 2022
medline: 5 4 2022
Statut: epublish

Résumé

Esophageal cancer is the seventh most common type of cancer in the world, the sixth leading cause of cancer-related death and its incidence is expected to rise 140% in the world in a period of 10 years until 2025. The overall incidence is higher in males, while data about prognosis and survival are not well established yet. The goal of this study was to carry out a comprehensive analysis of differences between sexes and other covariates in patients diagnosed with primary esophageal cancer. Data from 2005 to 2020 were obtained from the University Hospitals (UH) Seidman Cancer Center and from 2005 to 2018 from SEER. Patients were categorized according to histological subtype and divided according to sex. Pearson Chi-square test was used to compare variables of interest by sex and the influence of sex on survival was assessed by Kaplan Meier, log rank tests and Cox proportional hazards regression models. A total of 1205 patients were used for analysis. Sex differences in all types were found for age at diagnosis, histology, smoking status and prescriptions of NSAIDs and in SCC for age at diagnosis and alcoholism. Survival analysis didn't showed differences between males and females on univariable and multivariable models. Males have a higher incidence of Esophageal Cancer and its two main subtypes but none of the comprehensive set of variables analyzed showed to be strongly or unique correlated with this sex difference in incidence nor are they associated with a sex difference in survival.

Identifiants

DOI: 10.1038/s41598-022-09193-x PMID: 35347189 PMC: PMC8960903
pubmed: 35347189
doi: 10.1038/s41598-022-09193-x
pii: 10.1038/s41598-022-09193-x
pmc: PMC8960903
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5248

Subventions

Organisme : NCI NIH HHS
ID : P50 CA150964
Pays : United States

Informations de copyright

© 2022. The Author(s).

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Auteurs

Nickolas Stabellini (N)

Graduate Education Office, Case Western Reserve University School of Medicine, Cleveland, OH, USA. nickolas@case.edu.
Department of Hematology-Oncology, University Hospitals Seidman Cancer Center, Breen Pavilion-11100 Euclid Ave, Cleveland, OH, 44106, USA. nickolas@case.edu.
Faculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil. nickolas@case.edu.
Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA. nickolas@case.edu.

Apoorva Krishna Chandar (AK)

Department of Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Amitabh Chak (A)

Division of Gastroenterology and Liver Disease, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Amie J Barda (AJ)

Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Department of Pediatrics, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Mantas Dmukauskas (M)

Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Kristin Waite (K)

Trans-Divisional Research Program (TDRP), Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Jill S Barnholtz-Sloan (JS)

Trans-Divisional Research Program (TDRP), Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Center for Biomedical Informatics and Information Technology (CBIIT), National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Lois statistiques › Loi du khi-deux › Sex differences in esophageal cancer overall...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Tumeurs gastro-intestinales › Tumeurs de l'oesophage › Sex differences in esophageal cancer overall...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Sex differences in esophageal cancer overall...
questionsmedicales.fr › Diagnostic › Pronostic › Sex differences in esophageal cancer overall...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Modèles des risques proportionnels › Sex differences in esophageal cancer overall...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Caractères sexuels › Sex differences in esophageal cancer overall...