ATP-sensitive inward rectifier potassium channels reveal functional linkage between salivary gland function and blood feeding in the mosquito, Aedes aegypti.


Journal

Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179

Informations de publication

Date de publication:
28 03 2022
Historique:
received: 18 08 2021
accepted: 02 03 2022
entrez: 29 3 2022
pubmed: 30 3 2022
medline: 19 4 2022
Statut: epublish

Résumé

Reducing saliva secretions into the vertebrate host reduces feeding efficacy by most hematophagous arthropods. However, seminal studies suggested saliva is not a prerequisite for blood feeding in Aedes aegypti. To test this paradigm, we manually transected the salivary duct of female A. aegypti and an inability to salivate was correlated to an inability to imbibe blood. These data justified testing the relevance of inwardly rectifying potassium (Kir) channels in the A. aegypti salivary gland as an antifeedant target site. Pharmacological activation of ATP-gated Kir (K

Identifiants

pubmed: 35347209
doi: 10.1038/s42003-022-03222-1
pii: 10.1038/s42003-022-03222-1
pmc: PMC8960802
doi:

Substances chimiques

KATP Channels 0
Potassium Channels, Inwardly Rectifying 0
Adenosine Triphosphate 8L70Q75FXE

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

278

Subventions

Organisme : United States Department of Agriculture | Agricultural Research Service (USDA Agricultural Research Service)
ID : LAB94313

Informations de copyright

© 2022. The Author(s).

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Auteurs

Zhilin Li (Z)

Louisiana State University AgCenter, Department of Entomology, Baton Rouge, LA, 70803, USA.

Alexander Soohoo-Hui (A)

Louisiana State University AgCenter, Department of Entomology, Baton Rouge, LA, 70803, USA.

Flinn M O'Hara (FM)

Louisiana State University AgCenter, Department of Entomology, Baton Rouge, LA, 70803, USA.

Daniel R Swale (DR)

Louisiana State University AgCenter, Department of Entomology, Baton Rouge, LA, 70803, USA. DSwale@agcenter.lsu.edu.

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Classifications MeSH