Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response.

Animals Antimalarials / pharmacology Artemisinins Drug Resistance / genetics Malaria, Falciparum / drug therapy Parasites Plasmodium falciparum

Journal

Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179

Informations de publication

Date de publication:
28 03 2022
Historique:
received: 28 05 2021
accepted: 16 02 2022
entrez: 29 3 2022
pubmed: 30 3 2022
medline: 19 4 2022
Statut: epublish

Résumé

The emergence and spread of artemisinin-resistant Plasmodium falciparum, first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria elimination ambitions. To investigate the artemisinin resistance mechanism, transcriptome analysis was conducted of 577 P. falciparum isolates collected in the GMS between 2016-2018. A specific artemisinin resistance-associated transcriptional profile was identified that involves a broad but discrete set of biological functions related to proteotoxic stress, host cytoplasm remodelling, and REDOX metabolism. The artemisinin resistance-associated transcriptional profile evolved from initial transcriptional responses of susceptible parasites to artemisinin. The genetic basis for this adapted response is likely to be complex.

Identifiants

DOI: 10.1038/s42003-022-03215-0 PMID: 35347215 PMC: PMC8960834
pubmed: 35347215
doi: 10.1038/s42003-022-03215-0
pii: 10.1038/s42003-022-03215-0
pmc: PMC8960834
doi:

Substances chimiques

Antimalarials 0
Artemisinins 0
artemisinin 9RMU91N5K2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

274

Subventions

Organisme : Wellcome Trust (Wellcome)
ID : 220211/A/20/Z
Organisme : Ministry of Health -Singapore (MOH)
ID : NMRC/OFIRG/0040/2017
Organisme : Wellcome Trust (Wellcome)
ID : 220211/Z/20/Z
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Ministry of Education - Singapore (MOE)
ID : MOE2019-T3-1-007

Informations de copyright

© 2022. The Author(s).

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Auteurs

Lei Zhu (L)

School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.

Rob W van der Pluijm (RW)

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Center of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Michal Kucharski (M)

School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
ORCID: 0000-0002-1505-5608

Sourav Nayak (S)

School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.

Jaishree Tripathi (J)

School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.

Nicholas J White (NJ)

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Nicholas P J Day (NPJ)

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Abul Faiz (A)

Ramu Upazila Health Complex, Cox's Bazar, Bangladesh.
Malaria Research Group and Dev Care Foundation, Dhaka, Bangladesh.

Aung Pyae Phyo (AP)

Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Myanmar Oxford Clinical Research Unit, Yangon, Myanmar.
ORCID: 0000-0002-0383-9624

Chanaki Amaratunga (C)

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.

Dysoley Lek (D)

National Centre for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia.

Elizabeth A Ashley (EA)

Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit, Vientiane, Laos.
ORCID: 0000-0002-7620-4822

François Nosten (F)

Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.
ORCID: 0000-0002-7951-0745

Frank Smithuis (F)

Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Myanmar Oxford Clinical Research Unit, Yangon, Myanmar.

Hagai Ginsburg (H)

The Alexander Silberman Institute of Life Science, Hebrew University of Jerusalem, Jerusalem, Israel.

Lorenz von Seidlein (L)

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Khin Lin (K)

Department of Medical Research, Pyin Oo Lwin, Myanmar.

Mallika Imwong (M)

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Kesinee Chotivanich (K)

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Mayfong Mayxay (M)

Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit, Vientiane, Laos.
Institute of Research and Education Development (IRED), University of Health Sciences, Ministry of Health, Vientiane, Laos.

Mehul Dhorda (M)

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
WorldWide Antimalarial Resistance Network - Asia-Pacific Regional Centre, Bangkok, Thailand.

Hoang Chau Nguyen (HC)

Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.

Thuy Nhien Thanh Nguyen (TNT)

Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.

Olivo Miotto (O)

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Medical Research Council (MRC) Centre for Genomics and Global Health, University of Oxford, Oxford, UK.
Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
ORCID: 0000-0001-8060-6771

Paul N Newton (PN)

Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit, Vientiane, Laos.

Podjanee Jittamala (P)

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Rupam Tripura (R)

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Sasithon Pukrittayakamee (S)

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Department of Medical Research, Pyin Oo Lwin, Myanmar.
The Royal Society of Thailand, Dusit, Bangkok, Thailand.

Thomas J Peto (TJ)

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
ORCID: 0000-0003-3197-9891

Tran Tinh Hien (TT)

Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Arjen M Dondorp (AM)

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. arjen@tropmedres.ac.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK. arjen@tropmedres.ac.
ORCID: 0000-0001-5190-2395

Zbynek Bozdech (Z)

School of Biological Sciences, Nanyang Technological University, Singapore, Singapore. zbozdech@ntu.edu.sg.
Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. zbozdech@ntu.edu.sg.
ORCID: 0000-0002-9830-8446

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Artemisinin resistance in the malaria...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Antipaludiques › Artemisinin resistance in the malaria...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Sesquiterpènes › Artémisinines › Artemisinin resistance in the malaria...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Artemisinin resistance in the malaria...
questionsmedicales.fr › Infection › Maladies vectorielles › Paludisme › Paludisme à Plasmodium falciparum › Artemisinin resistance in the malaria...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Parasites › Artemisinin resistance in the malaria...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Haemosporida › Plasmodium › Plasmodium falciparum › Artemisinin resistance in the malaria...