Increasing access to hematopoietic cell transplantation in Latin America: results of the 2018 LABMT activity survey and trends since 2012.
Journal
Bone marrow transplantation
ISSN: 1476-5365
Titre abrégé: Bone Marrow Transplant
Pays: England
ID NLM: 8702459
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
29
10
2021
accepted:
23
02
2022
revised:
06
02
2022
pubmed:
30
3
2022
medline:
18
6
2022
entrez:
29
3
2022
Statut:
ppublish
Résumé
A total of 5642 hematopoietic cell transplants (HCT) in 5445 patients (2196-40% allogeneic and 3249-60% autologous) were reported by 127 teams in 14 Latin American countries that answered the 2018 LABMT/WBMT Global Transplant Activity survey. The transplant rate (defined as the number of first transplants per 10 million inhabitants per year) was 85 (51 autologous and 34 allogeneic) in 2018. The main indications for allogeneic HCT were acute leukemias (60%), while plasma cell disorders and lymphomas were the most common conditions warranting autologous HCT (50 and 36%, respectively). In the allogeneic HCT, HLA-identical siblings were the main type of donor (44%) followed by related mismatched/haploidentical donors (32%). Peripheral blood stem cells were used in 98% of the autologous and in 64% of the allogeneic transplants. From 2012 to 2018, there was a 64% increase of reported HCT (54% in autologous and 80% in allogeneic). In the allogeneic setting, the most pronounced increase in donor type was observed in haploidentical relatives (from 94 procedures in 2012 up to 710 in 2018), surpassing unrelated donors as of 2017. Significant trends detected in Latin America include rising numbers of the procedures reported, a faster increase in allogeneic HCT compared with autologous HCT and a significant increase in family mismatched/haploidentical donors. The LABMT/WBMT activity survey provides useful data to understand the HCT activity and trends in Latin America.
Identifiants
pubmed: 35347244
doi: 10.1038/s41409-022-01630-9
pii: 10.1038/s41409-022-01630-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
881-888Investigateurs
Cinthya Correa
(C)
Oscar Gonzalez-Ramella
(O)
Helen Baldomero
(H)
Ana Lisa Basquiera
(AL)
Rosio Baena
(R)
Leonardo Arcuri
(L)
Bárbara Puga
(B)
Carmen Rosales
(C)
Marlene Chávez
(M)
Calixto Hernández
(C)
Bella Maldonado
(B)
Andrés Gómez-De León
(A)
Ninotchka Mendoza
(N)
Cristóbal Frutos
(C)
Lourdes Aranda
(L)
Lilián Díaz
(L)
Marcos Hernández
(M)
Adriana Seber
(A)
Amado Karduss
(A)
Gregorio Jaimovich
(G)
Juliana Martínez-Rolon
(J)
Carmem Bonfim
(C)
Sebastian Galeano
(S)
Hildegard Greinix
(H)
Mickey B C Koh
(MBC)
Mahmoud Aljurf
(M)
Minako Iida
(M)
Wael Saber
(W)
Dietger Niederwieser
(D)
Yoshiko Atsuta
(Y)
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature Limited.
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