Coumestrol pre-treatment improves spatial learning and memory deficits following transient cerebral ischemia recruiting hippocampal GluR2 AMPA receptors.
GluR2
cerebral ischemia
coumestrol
hippocampus
neuroprotection
Journal
Hippocampus
ISSN: 1098-1063
Titre abrégé: Hippocampus
Pays: United States
ID NLM: 9108167
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
revised:
13
03
2022
received:
08
11
2021
accepted:
15
03
2022
pubmed:
30
3
2022
medline:
21
5
2022
entrez:
29
3
2022
Statut:
ppublish
Résumé
Transient global ischemia is a leading cause of learning and memory dysfunction and induces a pattern of delayed neuronal death in the CA1 subfield of the hippocampus by down-regulating GluR2 mRNA AMPA receptors in this cerebral area. This study sought to investigate the neuroprotective effect of coumestrol against spatial memory impairment induced by global ischemia that leads to neural death by reducing the GluR2 receptors content in the hippocampal CA1 area. Our studies demonstrated that coumestrol administration prevented spatial memory deficits in mice. These findings suggest a cognitive enhancement role of coumestrol against cognitive impairment in ischemic events.
Substances chimiques
Neuroprotective Agents
0
Receptors, AMPA
0
Coumestrol
V7NW98OB34
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
413-418Informations de copyright
© 2022 Wiley Periodicals LLC.
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