Expression of a Tumor Stem Cell Marker (Aldehyde Dehydrogenase 1-ALDH1) in Benign Epithelial Odontogenic Lesions.
Aldehyde dehydrogenase 1 family
Biomarkers
Immunohistochemistry
Odontogenic cysts
Odontogenic tumors
Stem cells
Journal
Head and neck pathology
ISSN: 1936-0568
Titre abrégé: Head Neck Pathol
Pays: United States
ID NLM: 101304010
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
26
11
2021
accepted:
10
02
2022
pubmed:
30
3
2022
medline:
31
8
2022
entrez:
29
3
2022
Statut:
ppublish
Résumé
The morphological diversity and different biological behaviors of human lesions has been attributed to the presence of cells with stem cell (SC) characteristics. Among SC markers, ALDH1 has been used in studies investigating different neoplasms and high expression of this marker was associated with clinicopathological features and prognosis in some groups. The aim of this study was to analyze the presence and distribution of SCs based on the expression of ALDH1 in epithelial odontogenic cysts and tumors. The sample consisted of 80 cases (20 dentigerous cysts (DCs), 20 odontogenic keratocysts (OKCs), 20 ameloblastomas (AMs), and 20 adenomatoid odontogenic tumors (AOTs). An immunoreactivity score was obtained from the percentage of positive cells and intensity of immunostaining. A level of 5% (p < 0.05) was adopted for the statistical tests. Immunoexpression of ALDH1 was observed in cytoplasm and nucleus-cytoplasm. The median scores indicated significantly higher expression in OKCs and DCs compared to AMs (p < 0.0001) and AOTs (p < 0.0001). In the tumor stroma and cystic capsule, immunoreactivity was detected in all odontogenic cysts studied and in 85% and 90% of AMs and AOTs, respectively. The expression of ALDH1 suggests the presence of SCs in the odontogenic lesions studied. Epithelial immunoexpression was higher in odontogenic cysts than in odontogenic tumors.
Identifiants
pubmed: 35349099
doi: 10.1007/s12105-022-01430-z
pii: 10.1007/s12105-022-01430-z
pmc: PMC9424418
doi:
Substances chimiques
Aldehyde Dehydrogenase 1 Family
EC 1.2.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
785-791Subventions
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : L.B.S is a Research Productivity Fellow at CNPq.
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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