Microbiota-microglia connections in age-related cognition decline.
cognitive aging
gut microbiota
microglia
neuroinflammation
Journal
Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
revised:
08
03
2022
received:
04
01
2022
accepted:
13
03
2022
pubmed:
30
3
2022
medline:
25
5
2022
entrez:
29
3
2022
Statut:
ppublish
Résumé
Aging is an inevitable process that all individuals experience, of which the extent differs among individuals. It has been recognized as the risk factor of neurodegenerative diseases by affecting gut microbiota compositions, microglia, and cognition abilities. Aging-induced changes in gut microbiota compositions have a critical role in orchestrating the morphology and functions of microglia through the gut-brain axis. Gut microbiota communicates with microglia by its secreted metabolites and neurotransmitters. This is highly associated with age-related cognitive declines. Here, we review the main composition of microbiota in the aged individuals, outline the changes of the brain in age-related cognitive decline from a neuroinflammation perspective, especially the changes of morphology and functions of microglia, discuss the crosstalk between microbiota and microglia in the aged brain and further highlight the role of microbiota-microglia connections in neurodegenerative diseases (Alzheimer's disease and Parkinson's disease).
Identifiants
pubmed: 35349746
doi: 10.1111/acel.13599
pmc: PMC9124309
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13599Informations de copyright
© 2022 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
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