Roles of RNA Modifications in Diverse Cellular Functions.
cellular functions
epitranscriptomics
m1A
m5C
m6A
therapeutics
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2022
2022
Historique:
received:
03
12
2021
accepted:
14
02
2022
entrez:
30
3
2022
pubmed:
31
3
2022
medline:
31
3
2022
Statut:
epublish
Résumé
Chemical modifications of RNA molecules regulate both RNA metabolism and fate. The deposition and function of these modifications are mediated by the actions of writer, reader, and eraser proteins. At the cellular level, RNA modifications regulate several cellular processes including cell death, proliferation, senescence, differentiation, migration, metabolism, autophagy, the DNA damage response, and liquid-liquid phase separation. Emerging evidence demonstrates that RNA modifications play active roles in the physiology and etiology of multiple diseases due to their pervasive roles in cellular functions. Here, we will summarize recent advances in the regulatory and functional role of RNA modifications in these cellular functions, emphasizing the context-specific roles of RNA modifications in mammalian systems. As m
Identifiants
pubmed: 35350378
doi: 10.3389/fcell.2022.828683
pii: 828683
pmc: PMC8957929
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
828683Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES024373
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES030576
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES031534
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009594
Pays : United States
Informations de copyright
Copyright © 2022 Wilkinson, Cui and He.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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