Analysis of lncRNA sequences: FAM3D-AS1, LINC01230, LINC01315 and LINC01468 in endometrial cancer.

Cell Proliferation / genetics Cytokines / metabolism Endometrial Neoplasms / genetics Female Gene Expression Regulation, Neoplastic Humans RNA, Long Noncoding / genetics
Endometrial cancer FAM3D-AS1 LINC01230 LINC01315 LINC01468 Long non-coding RNA lncRNA

Journal

BMC cancer
ISSN: 1471-2407
Titre abrégé: BMC Cancer
Pays: England
ID NLM: 100967800

Informations de publication

Date de publication:
29 Mar 2022
Historique:
received: 28 01 2022
accepted: 16 03 2022
entrez: 30 3 2022
pubmed: 31 3 2022
medline: 5 4 2022
Statut: epublish

Résumé

The analysis of long non-coding RNA (lncRNA) in endometrial cancer is a novel field of science. Although numerous lncRNA sequences have been identified until today, their correlation with endometrial cancer is still undetermined. The aim of this study was to analyze the expression of four lncRNA sequences: FAM3D-AS1, LINC01230, LINC01315 and LINC01468 and to investigate their significance in endometrial cancer. LncRNA sequences were investigated in paraffin blocks (tumor tissue and non-malignant endometrial tissue in archival postoperative specimens) in endometrial cancer patients (Cases, n = 120) and in cancer-free controls (n = 80) using real-time PCR assay. This study revealed a lower expression of LINC01468 in endometrial cancer patients than in controls. Both LINC01468 and FAM3D-AS1 were positively correlated with Body Mass Index (BMI) in cancer-free controls. LncRNA LINC01468 may be a protective factor in development of endometrial cancer.

Sections du résumé

BACKGROUND BACKGROUND
The analysis of long non-coding RNA (lncRNA) in endometrial cancer is a novel field of science. Although numerous lncRNA sequences have been identified until today, their correlation with endometrial cancer is still undetermined. The aim of this study was to analyze the expression of four lncRNA sequences: FAM3D-AS1, LINC01230, LINC01315 and LINC01468 and to investigate their significance in endometrial cancer.
METHODS METHODS
LncRNA sequences were investigated in paraffin blocks (tumor tissue and non-malignant endometrial tissue in archival postoperative specimens) in endometrial cancer patients (Cases, n = 120) and in cancer-free controls (n = 80) using real-time PCR assay.
RESULTS RESULTS
This study revealed a lower expression of LINC01468 in endometrial cancer patients than in controls. Both LINC01468 and FAM3D-AS1 were positively correlated with Body Mass Index (BMI) in cancer-free controls.
CONCLUSIONS CONCLUSIONS
LncRNA LINC01468 may be a protective factor in development of endometrial cancer.

Identifiants

DOI: 10.1186/s12885-022-09426-2 PMID: 35351056 PMC: PMC8966281
pubmed: 35351056
doi: 10.1186/s12885-022-09426-2
pii: 10.1186/s12885-022-09426-2
pmc: PMC8966281
doi:

Substances chimiques

Cytokines 0
FAM3D protein, human 0
RNA, Long Noncoding 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

343

Informations de copyright

© 2022. The Author(s).

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Auteurs

Jan Bieńkiewicz (J)

Department of Operative Gynecology, Endoscopy and Gynecologic Oncology, Polish Mother's Memorial Hospital - Research Institute, 281/289, Rzgowska Street, 93-338, Lodz, Poland. jan.bienkiewicz@iczmp.edu.pl.

Hanna Romanowicz (H)

Department of Clinical Pathology, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland.

Bożena Szymańska (B)

Research Laboratory CoreLab, Medical University of Lodz, Lodz, Poland.

Daria Domańska-Senderowska (D)

Department of Molecular Bases of Medicine, Medical University of Lodz, Lodz, Poland.

Miłosz Wilczyński (M)

Department of Operative Gynecology, Endoscopy and Gynecologic Oncology, Polish Mother's Memorial Hospital - Research Institute, 281/289, Rzgowska Street, 93-338, Lodz, Poland.

Anna Stepowicz (A)

Department of Obstetrics, Perinatology and Gynecology, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland.

Andrzej Malinowski (A)

Department of Operative and Endoscopic Gynecology, Medical University of Lodz, Lodz, Poland.

Beata Smolarz (B)

Department of Clinical Pathology, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Analysis of lncRNA sequences: FAM3D-AS1,...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Analysis of lncRNA sequences: FAM3D-AS1,...
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questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Analysis of lncRNA sequences: FAM3D-AS1,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Analysis of lncRNA sequences: FAM3D-AS1,...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › ARN long non codant › Analysis of lncRNA sequences: FAM3D-AS1,...