BRCA1/BARD1 is a nucleosome reader and writer.
DNA damage repair
chromatin regulation
homologous recombination
transcriptional regulation
ubiquitin ligase
Journal
Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
14
12
2021
revised:
14
02
2022
accepted:
01
03
2022
pubmed:
31
3
2022
medline:
15
6
2022
entrez:
30
3
2022
Statut:
ppublish
Résumé
Mutations in BRCA1 and BARD1 predispose carriers to breast and ovarian cancers. The BRCA1 and BARD1 proteins form a heterodimeric complex (BRCA1/BARD1) that regulates many biological processes, including transcription and DNA double-stranded break repair. These functions are mediated by the only known enzymatic activity of BRCA1/BARD1 in its capacity as an E3 ubiquitin ligase and its role as a central hub for many large protein complexes. But the mechanisms by which BRCA1/BARD1 interfaces with chromatin, where it exerts its major functions, have remained unknown. Here, we review recent advancements in structural and cellular biology that have provided critical insights into how BRCA1/BARD1 serves as both a nucleosome reader and writer to facilitate transcriptional regulation and DNA repair by homologous recombination.
Identifiants
pubmed: 35351360
pii: S0968-0004(22)00060-3
doi: 10.1016/j.tibs.2022.03.001
pmc: PMC9189015
mid: NIHMS1788555
pii:
doi:
Substances chimiques
BRCA1 Protein
0
Nucleosomes
0
Tumor Suppressor Proteins
0
Ubiquitin-Protein Ligases
EC 2.3.2.27
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
582-595Subventions
Organisme : NCI NIH HHS
ID : R01 CA260834
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM141091
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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