Neural readout of a latency code in the active electrosensory system.
CP: Neuroscience
active sensing
corollary discharge
electric fish
spike latency
temporal coding
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
29 03 2022
29 03 2022
Historique:
received:
23
12
2021
revised:
03
02
2022
accepted:
10
03
2022
entrez:
30
3
2022
pubmed:
31
3
2022
medline:
2
4
2022
Statut:
ppublish
Résumé
The latency of spikes relative to a stimulus conveys sensory information across modalities. However, in most cases, it remains unclear whether and how such latency codes are utilized by postsynaptic neurons. In the active electrosensory system of mormyrid fish, a latency code for stimulus amplitude in electroreceptor afferent nerve fibers (EAs) is hypothesized to be read out by a central reference provided by motor corollary discharge (CD). Here, we demonstrate that CD enhances sensory responses in postsynaptic granular cells of the electrosensory lobe but is not required for reading out EA input. Instead, diverse latency and spike count tuning across the EA population give rise to graded information about stimulus amplitude that can be read out by standard integration of converging excitatory synaptic inputs. Inhibitory control over the temporal window of integration renders two granular cell subclasses differentially sensitive to information derived from relative spike latency versus spike count.
Identifiants
pubmed: 35354029
pii: S2211-1247(22)00353-9
doi: 10.1016/j.celrep.2022.110605
pmc: PMC9045710
mid: NIHMS1793841
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
110605Subventions
Organisme : NINDS NIH HHS
ID : R01 NS075023
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS118448
Pays : United States
Organisme : NINDS NIH HHS
ID : RF1 NS118448
Pays : United States
Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
Références
Nat Rev Neurosci. 2008 Aug;9(8):587-600
pubmed: 18641666
J Neurosci. 2006 Jul 26;26(30):8009-16
pubmed: 16870746
Nat Neurosci. 2013 Jul;16(7):949-57
pubmed: 23685720
J Comp Neurol. 1984 Feb 20;223(2):163-76
pubmed: 6200517
Curr Opin Neurobiol. 2011 Oct;21(5):745-51
pubmed: 21646012
Curr Opin Neurobiol. 2004 Aug;14(4):461-7
pubmed: 15321067
Nat Commun. 2018 Sep 12;9(1):3691
pubmed: 30209249
J Exp Biol. 1989 Sep;146:229-53
pubmed: 2689564
Neuron. 2010 Nov 4;68(3):570-85
pubmed: 21040855
J Neurophysiol. 1990 Feb;63(2):319-32
pubmed: 2313348
Hear Res. 1990 May;45(3):191-202
pubmed: 2358413
Neuron. 2008 Feb 28;57(4):586-98
pubmed: 18304487
Nat Neurosci. 2004 Feb;7(2):170-7
pubmed: 14730306
Curr Opin Neurobiol. 2000 Aug;10(4):467-73
pubmed: 10981615
J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2005 Apr;191(4):331-45
pubmed: 15800793
J Neurophysiol. 1990 Feb;63(2):303-18
pubmed: 2313347
J Neurosci. 1998 Aug 1;18(15):6009-25
pubmed: 9671686
Nat Neurosci. 2013 Mar;16(3):259-63
pubmed: 23434978
Exp Brain Res. 2000 Feb;130(3):277-97
pubmed: 10706428
J Neurophysiol. 1996 Aug;76(2):1356-60
pubmed: 8871243
J Neurosci. 2006 Aug 9;26(32):8221-34
pubmed: 16899717
J Neurophysiol. 2007 Mar;97(3):2191-203
pubmed: 17229820
Philos Trans R Soc Lond B Biol Sci. 2014 Jan 20;369(1637):20120467
pubmed: 24446501
Neural Netw. 2001 Jul-Sep;14(6-7):715-25
pubmed: 11665765
Trends Neurosci. 2005 Jan;28(1):1-4
pubmed: 15626490
J Neurosci. 2012 Feb 29;32(9):2998-3008
pubmed: 22378873
J Comp Neurol. 2005 Feb 28;483(1):124-42
pubmed: 15672392
J Neurosci. 2013 Jul 17;33(29):12003-12
pubmed: 23864687
Nat Neurosci. 2011 Jul 17;14(8):1039-44
pubmed: 21765422
Nat Rev Neurosci. 2003 Jul;4(7):540-50
pubmed: 12838329
Neuron. 2010 May 27;66(4):573-84
pubmed: 20510861
Annu Rev Neurosci. 2014;37:363-85
pubmed: 24905594
J Neurophysiol. 1992 Sep;68(3):843-58
pubmed: 1432052
J Neurosci. 2011 Jun 22;31(25):9192-204
pubmed: 21697370
Curr Biol. 2003 Mar 18;13(6):493-7
pubmed: 12646132
Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5175-80
pubmed: 17360369
Curr Opin Neurobiol. 2018 Oct;52:18-24
pubmed: 29694923
Nature. 2011 Oct 12;479(7373):397-400
pubmed: 21993623
J Neurosci. 2008 Feb 13;28(7):1598-612
pubmed: 18272681
J Neurosci. 2010 Feb 10;30(6):1994-2006
pubmed: 20147528
J Comp Neurol. 1989 Aug 15;286(3):391-407
pubmed: 2768566
J Neurophysiol. 2003 Aug;90(2):1211-23
pubmed: 12904506
Front Comput Neurosci. 2016 Oct 20;10:107
pubmed: 27812332
Nat Neurosci. 2006 Mar;9(3):420-8
pubmed: 16474393
J Neurophysiol. 2000 Mar;83(3):1592-604
pubmed: 10712482
J Neurophysiol. 2002 Apr;87(4):1749-62
pubmed: 11929896
Science. 2008 Feb 22;319(5866):1108-11
pubmed: 18292344
J Comp Neurol. 2008 Nov 20;511(3):342-59
pubmed: 18803238
J Comp Neurol. 1996 Nov 04;375(1):18-42
pubmed: 8913891
Science. 2020 Jun 19;368(6497):
pubmed: 32554567
Neuron. 2001 Mar;29(3):769-77
pubmed: 11301035
Science. 1983 Sep 16;221(4616):1206-8
pubmed: 6612337
J Physiol Paris. 2016 Oct;110(3 Pt B):190-199
pubmed: 27815181
Nature. 2013 May 9;497(7448):205-10
pubmed: 23624373
Elife. 2018 Mar 29;7:
pubmed: 29595470
Curr Biol. 2018 Nov 19;28(22):3648-3653.e2
pubmed: 30416061
J Comput Neurosci. 1995 Jun;2(2):149-62
pubmed: 8521284
Curr Opin Neurobiol. 2016 Oct;40:142-149
pubmed: 27504741
J Comp Neurol. 2001 Mar 12;431(3):255-75
pubmed: 11170004
Science. 1982 Jun 11;216(4551):1239-41
pubmed: 7079757
Elife. 2019 Aug 20;8:
pubmed: 31429824
J Exp Biol. 1999 May;202(# (Pt 10)):1291-300
pubmed: 10210669
J Neurophysiol. 2013 Nov;110(10):2295-311
pubmed: 23966672
J Exp Biol. 2004 Jun;207(Pt 14):2443-53
pubmed: 15184516
Nat Neurosci. 2014 Mar;17(3):416-22
pubmed: 24531306