Cross-reactivity of glycan-reactive HIV-1 broadly neutralizing antibodies with parasite glycans.
CP: Immunology
HIV-1
Schisotosoma mansoni
glycan epitope
neutralizing antibody
vaccine
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
29 03 2022
29 03 2022
Historique:
received:
21
10
2021
revised:
26
01
2022
accepted:
11
03
2022
entrez:
30
3
2022
pubmed:
31
3
2022
medline:
2
4
2022
Statut:
ppublish
Résumé
The HIV-1 Envelope glycoprotein (Env) is the sole target for broadly neutralizing antibodies (bnAbs). Env is heavily glycosylated with host-derived N-glycans, and many bnAbs bind to, or are dependent upon, Env glycans for neutralization. Although glycan-binding bnAbs are frequently detected in HIV-infected individuals, attempts to elicit them have been unsuccessful because of the poor immunogenicity of Env N-glycans. Here, we report cross-reactivity of glycan-binding bnAbs with self- and non-self N-glycans and glycoprotein antigens from different life-stages of Schistosoma mansoni. Using the IAVI Protocol C HIV infection cohort, we examine the relationship between S. mansoni seropositivity and development of bnAbs targeting glycan-dependent epitopes. We show that the unmutated common ancestor of the N332/V3-specific bnAb lineage PCDN76, isolated from an HIV-infected donor with S. mansoni seropositivity, binds to S. mansoni cercariae while lacking reactivity to gp120. Overall, these results present a strategy for elicitation of glycan-reactive bnAbs which could be exploited in HIV-1 vaccine development.
Identifiants
pubmed: 35354052
pii: S2211-1247(22)00359-X
doi: 10.1016/j.celrep.2022.110611
pmc: PMC10073069
pii:
doi:
Substances chimiques
Antibodies, Neutralizing
0
Broadly Neutralizing Antibodies
0
HIV Antibodies
0
Polysaccharides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
110611Subventions
Organisme : Medical Research Council
ID : MR/K024426/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 104958/Z/14/Z
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P010660/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M011216/1
Pays : United Kingdom
Investigateurs
Susan Allen
(S)
William Kilembe
(W)
Shabir Lakhi
(S)
Mubiana Inambao
(M)
Etienne Karita
(E)
Anatoli Kamali
(A)
Eduard J Sanders
(EJ)
Omu Anzala
(O)
Vinodh Edward
(V)
Linda-Gail Bekker
(LG)
Jianming Tang
(J)
Jill Gilmour
(J)
Eric Hunter
(E)
Matt Price
(M)
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
Références
PLoS Negl Trop Dis. 2017 Sep 25;11(9):e0005968
pubmed: 28945756
J Med Chem. 2004 Mar 25;47(7):1739-49
pubmed: 15027865
AIDS. 2008 Oct 18;22(16):2214-7
pubmed: 18832887
PLoS Pathog. 2021 Mar 22;17(3):e1009407
pubmed: 33750987
PLoS Pathog. 2013;9(5):e1003342
pubmed: 23658524
Immunity. 2016 Jul 19;45(1):31-45
pubmed: 27438765
Nature. 2011 Sep 22;477(7365):466-70
pubmed: 21849977
J Virol. 1999 May;73(5):4009-18
pubmed: 10196297
J Virol. 2015 Sep;89(17):8932-44
pubmed: 26085151
Immunity. 2015 Dec 15;43(6):1053-63
pubmed: 26682982
Science. 2015 Aug 14;349(6249):aab1253
pubmed: 26229114
J Virol. 1996 Feb;70(2):1100-8
pubmed: 8551569
J Virol. 2012 Apr;86(8):4394-403
pubmed: 22345481
Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13800-5
pubmed: 20643940
ACS Chem Biol. 2015 May 15;10(5):1290-302
pubmed: 25664929
Immunity. 2016 May 17;44(5):1215-26
pubmed: 27192579
Cell Rep. 2018 Oct 23;25(4):893-908.e7
pubmed: 30355496
PLoS Pathog. 2016 Jan 14;12(1):e1005369
pubmed: 26766578
J Biomed Sci. 2020 Jan 3;27(1):9
pubmed: 31900143
J Virol. 2009 Jul;83(14):7337-48
pubmed: 19439467
J Virol. 2008 Jul;82(13):6447-57
pubmed: 18434410
J Virol. 2011 May;85(10):4828-40
pubmed: 21389135
Immunity. 2014 May 15;40(5):657-68
pubmed: 24768347
Immunity. 2019 Nov 19;51(5):915-929.e7
pubmed: 31732167
Nature. 2012 Nov 15;491(7424):406-12
pubmed: 23151583
J Chem Theory Comput. 2015 Aug 11;11(8):3696-713
pubmed: 26574453
Sci Transl Med. 2017 Jan 18;9(373):
pubmed: 28100831
J Exp Med. 2011 Oct 24;208(11):2237-49
pubmed: 21987658
Cell Host Microbe. 2014 Aug 13;16(2):215-226
pubmed: 25121750
Nat Rev Drug Discov. 2010 Apr;9(4):308-24
pubmed: 20357803
J Am Chem Soc. 2001 Jun 27;123(25):6108-17
pubmed: 11414845
Biotechnol Genet Eng Rev. 2019 Oct;35(2):93-125
pubmed: 32048549
Science. 2009 Oct 9;326(5950):285-9
pubmed: 19729618
AIDS. 2013 Nov 13;27(17):2775-86
pubmed: 24113395
Science. 2015 Jul 10;349(6244):aac4223
pubmed: 26089353
Chem Biol. 2012 Feb 24;19(2):254-63
pubmed: 22365608
Sci Transl Med. 2017 Mar 15;9(381):
pubmed: 28298420
J Virol. 2010 Oct;84(20):10690-9
pubmed: 20702629
Science. 2013 Dec 20;342(6165):1477-83
pubmed: 24179159
Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18921-5
pubmed: 23100539
Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3690-5
pubmed: 18310320
J Virol. 2009 May;83(10):4861-70
pubmed: 19264785
AIDS. 2014 Jan 14;28(2):163-9
pubmed: 24361678
Cell. 2021 May 27;184(11):2955-2972.e25
pubmed: 34019795
ACS Chem Biol. 2018 Aug 17;13(8):2269-2279
pubmed: 29894153
Immunity. 2019 Jan 15;50(1):241-252.e6
pubmed: 30552025
Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):E3268-77
pubmed: 23115339
J Virol. 2010 Oct;84(20):10700-7
pubmed: 20702640
J Virol. 2019 Feb 5;93(4):
pubmed: 30487280
J Virol. 2015 Jan 15;89(2):1105-18
pubmed: 25378488
Int J Parasitol. 2015 Jun;45(7):465-75
pubmed: 25819714
Nat Immunol. 2018 Jun;19(6):617-624
pubmed: 29760533
PLoS Negl Trop Dis. 2018 Jul 2;12(7):e0006613
pubmed: 29965987
Glycobiology. 2010 Jul;20(7):812-23
pubmed: 20181792
An Acad Bras Cienc. 2005 Jun;77(2):293-324
pubmed: 15895165
AIDS. 2003 Mar 28;17(5):685-9
pubmed: 12646791
PLoS Negl Trop Dis. 2011 Mar 08;5(3):e1009
pubmed: 21408085
Front Immunol. 2018 Oct 09;9:2331
pubmed: 30356796
Cell Rep. 2016 Aug 30;16(9):2327-38
pubmed: 27545891
Eur Biophys J. 2011 Dec;40(12):1357-69
pubmed: 21947507
Cell Rep. 2016 Mar 22;14(11):2695-706
pubmed: 26972002
Anal Chem. 2007 Nov 1;79(21):8107-13
pubmed: 17922555
Science. 2010 Aug 13;329(5993):811-7
pubmed: 20616231
PLoS Negl Trop Dis. 2012;6(11):e1922
pubmed: 23209862
Nature. 2014 May 1;509(7498):55-62
pubmed: 24590074
J Med Chem. 2004 Mar 25;47(7):1750-9
pubmed: 15027866
Biochemistry. 2000 Sep 19;39(37):11194-204
pubmed: 10985765
Nature. 2013 Apr 25;496(7446):469-76
pubmed: 23552890