Incidence of lower respiratory tract infection and associated viruses in a birth cohort in the Philippines.
Birth cohort
Incidence
Lower respiratory tract infection
Philippines
Respiratory virus
Journal
BMC infectious diseases
ISSN: 1471-2334
Titre abrégé: BMC Infect Dis
Pays: England
ID NLM: 100968551
Informations de publication
Date de publication:
30 Mar 2022
30 Mar 2022
Historique:
received:
30
11
2021
accepted:
10
03
2022
entrez:
31
3
2022
pubmed:
1
4
2022
medline:
2
4
2022
Statut:
epublish
Résumé
Lower respiratory tract infection (LRTI) is an important cause of morbidity and mortality in infants and young children. However, the etiological role of viruses and the timing of developing LRTI are not well defined. We analyzed the data of a prospective cohort study in the Philippines as a birth cohort. We detected LRTI among children who visited healthcare facilities with respiratory symptom, and collected nasopharyngeal swabs for virus detection. We analyzed the incidence rates (IRs) and cumulative proportion of LRTI and severe LRTI by age group and each virus detected. A total of 350 LRTI episodes were observed from 473 child-years yielded from 419 children. The IRs of LRTI were 70.8, 70.7, and 80.8 per 100 child-years for 0-5, 6-11, and 12-23 months of age, respectively. By 12 months of age, 45% of children developed LRTI at least once. Rhinovirus and respiratory syncytial virus were the most frequently detected viruses in all age groups. However, the IRs of influenza virus were low especially at 0-5 months of age. We identified various patterns of age-specific IRs of LRTI and severe LRTI for different viruses, which should be considered to establish more effective interventions including vaccinations.
Sections du résumé
BACKGROUND
BACKGROUND
Lower respiratory tract infection (LRTI) is an important cause of morbidity and mortality in infants and young children. However, the etiological role of viruses and the timing of developing LRTI are not well defined.
METHODS
METHODS
We analyzed the data of a prospective cohort study in the Philippines as a birth cohort. We detected LRTI among children who visited healthcare facilities with respiratory symptom, and collected nasopharyngeal swabs for virus detection. We analyzed the incidence rates (IRs) and cumulative proportion of LRTI and severe LRTI by age group and each virus detected.
RESULTS
RESULTS
A total of 350 LRTI episodes were observed from 473 child-years yielded from 419 children. The IRs of LRTI were 70.8, 70.7, and 80.8 per 100 child-years for 0-5, 6-11, and 12-23 months of age, respectively. By 12 months of age, 45% of children developed LRTI at least once. Rhinovirus and respiratory syncytial virus were the most frequently detected viruses in all age groups. However, the IRs of influenza virus were low especially at 0-5 months of age.
CONCLUSIONS
CONCLUSIONS
We identified various patterns of age-specific IRs of LRTI and severe LRTI for different viruses, which should be considered to establish more effective interventions including vaccinations.
Identifiants
pubmed: 35354368
doi: 10.1186/s12879-022-07289-3
pii: 10.1186/s12879-022-07289-3
pmc: PMC8966153
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
313Subventions
Organisme : the Science and Technology Research Partnership for Sustainable Development
ID : JP16jm0110001
Organisme : the Japan Initiative for Global Research Network on Infectious Diseases
ID : JP16fm0108013
Organisme : KAKENHI
ID : JP16H02642, JP19H01072
Informations de copyright
© 2022. The Author(s).
Références
Pediatr Pulmonol. 2016 Dec;51(12):1336-1346
pubmed: 27228308
PLoS One. 2015 May 04;10(5):e0125009
pubmed: 25938584
Lancet. 2009 Sep 12;374(9693):893-902
pubmed: 19748398
BMC Infect Dis. 2012 Oct 23;12:267
pubmed: 23092190
Am J Dis Child. 1986 Jun;140(6):543-6
pubmed: 3706232
J Med Virol. 2003 Jun;70(2):228-39
pubmed: 12696109
J Clin Microbiol. 2009 Sep;47(9):2981-4
pubmed: 19571031
PLoS Med. 2013;10(5):e1001444
pubmed: 23690754
J Pediatric Infect Dis Soc. 2020 Feb 28;9(1):21-29
pubmed: 30423150
PLoS One. 2015 Nov 05;10(11):e0142192
pubmed: 26540236
Clin Infect Dis. 2020 May 6;70(10):2029-2035
pubmed: 31257406
J Infect Dis. 2018 Jan 17;217(3):418-427
pubmed: 29165576
Pediatr Infect Dis J. 2019 Apr;38(4):344-350
pubmed: 30882722
J Glob Health. 2015 Jun;5(1):010408
pubmed: 26445672
Pediatr Infect Dis J. 2011 Sep;30(9):778-84
pubmed: 21487330
Jpn J Infect Dis. 2014;67(2):105-10
pubmed: 24647252
Clin Infect Dis. 2020 Jan 1;70(1):59-66
pubmed: 30810160
Lancet. 2017 Sep 16;390(10100):1151-1210
pubmed: 28919116
J Virol Methods. 2005 Jun;126(1-2):53-63
pubmed: 15847919
J Clin Microbiol. 2005 Jan;43(1):36-40
pubmed: 15634948
Wkly Epidemiol Rec. 2012 Nov 23;87(47):461-76
pubmed: 23210147
Emerg Infect Dis. 2011 Aug;17(8):1430-5
pubmed: 21801620
Clin Infect Dis. 2008 Jan 1;46(1):50-7
pubmed: 18171213
N Engl J Med. 2000 Jan 27;342(4):232-9
pubmed: 10648764
Lancet Respir Med. 2016 Jun;4(6):463-72
pubmed: 27117547
N Engl J Med. 2014 Sep 4;371(10):918-31
pubmed: 25184864
Pediatr Infect Dis J. 1997 Nov;16(11):1065-8
pubmed: 9384341
Lancet. 2011 Dec 3;378(9807):1917-30
pubmed: 22078723
Vaccine. 2016 Jan 4;34(2):190-197
pubmed: 26100926
Influenza Other Respir Viruses. 2019 Jul;13(4):339-353
pubmed: 30891896
Lancet Glob Health. 2018 Jul;6(7):e744-e757
pubmed: 29903376
J Gen Virol. 1998 Sep;79 ( Pt 9):2221-9
pubmed: 9747732
J Glob Health. 2019 Jun;9(1):010433
pubmed: 31131104
J Infect Dis. 2004 Nov 15;190(10):1828-32
pubmed: 15499540
Lancet. 2017 Sep 2;390(10098):946-958
pubmed: 28689664
J Infect Dis. 2019 Jan 7;219(2):197-205
pubmed: 30189092
Pediatr Infect Dis J. 2006 Aug;25(8):680-6
pubmed: 16874165
PLoS One. 2007 Jun 06;2(6):e491
pubmed: 17551572
Lancet Infect Dis. 2018 Oct;18(10):e295-e311
pubmed: 29914800
Lancet Infect Dis. 2018 Nov;18(11):1191-1210
pubmed: 30243584
BMJ Open. 2019 Mar 30;9(3):e026895
pubmed: 30928958
Clin Microbiol Infect. 2007 May;13(5):504-9
pubmed: 17263836
Pediatr Infect Dis J. 2008 Jan;27(1):59-64
pubmed: 18162940
J Med Virol. 2004 Apr;72(4):695-9
pubmed: 14981776
Clin Infect Dis. 2019 Oct 15;69(9):1588-1596
pubmed: 30925191