Hsa_circ_0007967 promotes gastric cancer proliferation through the miR-411-5p/MAML3 axis.
Journal
Cell death discovery
ISSN: 2058-7716
Titre abrégé: Cell Death Discov
Pays: United States
ID NLM: 101665035
Informations de publication
Date de publication:
30 Mar 2022
30 Mar 2022
Historique:
received:
30
12
2021
accepted:
17
03
2022
revised:
10
03
2022
entrez:
31
3
2022
pubmed:
1
4
2022
medline:
1
4
2022
Statut:
epublish
Résumé
Circular RNAs are an important kind of noncoding RNAs and involved in cancerogenesis, but the specific mechanism between gastric cancer and circRNAs needs further study. Hsa_circ_0007967 was selected by RNA sequencing. Here, hsa_circ_0007967 was highly expressed in gastric cancer tissues than adjacent normal tissues. Overexpressing hsa_circ_0007967 promoted gastric cancer cell proliferation in vitro and in vivo, while suppression of hsa_circ_0007967 inhibited gastric cancer cell proliferation in vitro and in vivo. Mechanistically, hsa_circ_0007967 sponged miR-411-5p to increase MAML3 expression. Overall, hsa_circ_0007967 is a promising biomarker for gastric cancer diagnosis and a potential molecule for gastric cancer treatment.
Identifiants
pubmed: 35354791
doi: 10.1038/s41420-022-00954-1
pii: 10.1038/s41420-022-00954-1
pmc: PMC8969178
doi:
Types de publication
Journal Article
Langues
eng
Pagination
144Subventions
Organisme : Government of Jiangsu Province (Jiangsu Province)
ID : Z2019057
Organisme : Government of Jiangsu Province (Jiangsu Province)
ID : Z2019057
Organisme : Government of Jiangsu Province (Jiangsu Province)
ID : Z2019057
Organisme : Government of Jiangsu Province (Jiangsu Province)
ID : Z2019057
Organisme : Government of Jiangsu Province (Jiangsu Province)
ID : Z2019057
Organisme : Government of Jiangsu Province (Jiangsu Province)
ID : Z2019057
Organisme : Government of Jiangsu Province (Jiangsu Province)
ID : Z2019057
Organisme : Government of Jiangsu Province (Jiangsu Province)
ID : Z2019057
Organisme : Government of Jiangsu Province (Jiangsu Province)
ID : Z2019057
Organisme : Government of Jiangsu Province (Jiangsu Province)
ID : Z2019057
Organisme : Government of Jiangsu Province (Jiangsu Province)
ID : Z2019057
Informations de copyright
© 2022. The Author(s).
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