Reduced neural activity but improved coding in rodent higher-order visual cortex during locomotion.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
30 03 2022
30 03 2022
Historique:
received:
14
11
2017
accepted:
04
03
2022
entrez:
31
3
2022
pubmed:
1
4
2022
medline:
2
4
2022
Statut:
epublish
Résumé
Running profoundly alters stimulus-response properties in mouse primary visual cortex (V1), but its effect in higher-order visual cortex is under-explored. Here we systematically investigate how visual responses vary with locomotive state across six visual areas and three cortical layers using a massive dataset from the Allen Brain Institute. Although previous work has shown running speed to be positively correlated with neural activity in V1, here we show that the sign of correlations between speed and neural activity varies across extra-striate cortex, and is even negative in anterior extra-striate cortex. Nevertheless, across all visual cortices, neural responses can be decoded more accurately during running than during stationary periods. We show that this effect is not attributable to changes in population activity structure, and propose that it instead arises from an increase in reliability of single-neuron responses during locomotion.
Identifiants
pubmed: 35354804
doi: 10.1038/s41467-022-29200-z
pii: 10.1038/s41467-022-29200-z
pmc: PMC8967903
doi:
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1676Subventions
Organisme : NIBIB NIH HHS
ID : R01 EB026946
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS104899
Pays : United States
Organisme : NINDS NIH HHS
ID : U19 NS104648
Pays : United States
Informations de copyright
© 2022. The Author(s).
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