Non-coding RNAs in Kawasaki disease: Molecular mechanisms and clinical implications.
Kawasaki disease
circRNA
endothelial dysfunction
immune dysfunction
inflammatory disorder
lncRNA
miRNA
Journal
BioEssays : news and reviews in molecular, cellular and developmental biology
ISSN: 1521-1878
Titre abrégé: Bioessays
Pays: United States
ID NLM: 8510851
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
revised:
10
03
2022
received:
29
10
2021
accepted:
11
03
2022
pubmed:
1
4
2022
medline:
25
5
2022
entrez:
31
3
2022
Statut:
ppublish
Résumé
Kawasaki disease (KD) is an acute self-limiting vasculitis with coronary complications, usually occurring in children. The incidence of KD in children is increasing year by year, mainly in East Asian countries, but relatively stably in Europe and America. Although studies on KD have been reported, the pathogenesis of KD is unknown. With the development of high-throughput sequencing technology, growing number of regulatory noncoding RNAs (ncRNAs) including microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA) have been identified to involved in KD. However, the role of ncRNAs in KD has not been comprehensively elucidated. Therefore, it is significative to study the regulatory role of ncRNA in KD, which might help to uncover new and effective therapeutic strategies for KD. In this review, we summarize recent studies on ncRNA in KD from the perspectives of immune disorders, inflammatory disorders, and endothelial dysfunction, and highlight the potential of ncRNAs as therapeutic targets for KD.
Identifiants
pubmed: 35355301
doi: 10.1002/bies.202100256
doi:
Substances chimiques
MicroRNAs
0
RNA, Circular
0
RNA, Long Noncoding
0
RNA, Untranslated
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2100256Informations de copyright
© 2022 Wiley Periodicals LLC.
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