Quantitative evaluation of cardiac glycosides and their seasonal variation analysis in Nerium oleander using UHPLC-ESI-MS/MS.
cardiac glycosides
odoroside A
odoroside H
oleandrin
quantitative analysis
Journal
Phytochemical analysis : PCA
ISSN: 1099-1565
Titre abrégé: Phytochem Anal
Pays: England
ID NLM: 9200492
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
revised:
28
02
2022
received:
20
10
2021
accepted:
21
03
2022
pubmed:
1
4
2022
medline:
7
7
2022
entrez:
31
3
2022
Statut:
ppublish
Résumé
Nerium oleander is an eminent source of structurally diverse cardiac glycosides (CGs), plays a prominent role in the treatment of heart failure, and inhibits the proliferation of cancer cell lines. CGs exert their cardiotonic action by binding to the extracellularly exposed recognition sites on Na We aimed to quantitatively determine CGs and their seasonal variation in leaf and stem samples of N. oleander utilizing UHPLC-ESI-MS/MS techniques. The UHPLC-ESI-MS/MS analytical method was developed utilizing multiple reaction monitoring (MRM) mode. The Waters BEH C18 (150 mm × 2.1 mm, 1.7 μm) column was used with a 22-min linear gradient consisting of acetonitrile and 5 mM ammonium acetate buffer. In total 21 CGs were quantitatively determined in the seasonal leaf and stem samples of N. oleander along with the absolute quantitation of the three chemical markers odoroside H (244.8 μg/g), odoroside A (231.4 μg/g), and oleandrin (703.9 μg/g). The season-specific accumulation of chemical markers was observed in the order of predominance odoroside A (summer season, stem), odoroside H (winter season, stem), and oleandrin (rainy season, leaf). Besides this, the remaining 18 CGs were relatively quantified in the same samples. The developed method is simple and reliable and can be used for the identification and quantification of multiple CGs in N. oleander.
Substances chimiques
Cardiac Glycosides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
746-753Subventions
Organisme : Science & Engineering Research Board (SERB) DST Govt. of India
ID : EMR/2016/006674
Organisme : Science & Engineering Research Board (SERB) DST Govt. of India
ID : YSS/2015/001048
Informations de copyright
© 2022 John Wiley & Sons, Ltd.
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